Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma

S E Deurvorst, O S Hoekstra, J A Castelijns, B I Witte, C R Leemans, R de Bree

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients.

DESIGN: All patients underwent 18 FDG PET/CT for the detection of distant metastases.

SETTING: Retrospective single-centre study.

PARTICIPANTS: Head and neck squamous cell carcinoma patients with high-risk factors for distant metastases.

MAIN OUTCOME MEASURES: Accuracy of 18 FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard. Comparison of overall survival between patients diagnosed with distant metastases during initial screening and patients diagnosed with distant metastases during follow-up.

RESULTS: In 23 (12%) of the 190 patients, 18 FDG PET/CT detected distant metastases at screening. Sensitivity and negative predictive value were 46.2% (95% CI 32.6-59.7) and 82.6% (95% CI 76.8-88.5). No difference in median overall survival from the time of distant metastases detection was found between patients diagnosed with DM during work-up or during follow-up.

CONCLUSIONS: In head and neck squamous cell carcinoma patients with high-risk factors, 18 FDG PET/CT has a high negative predictive value for the detection of distant metastases and should be used in daily clinical practice, although the sensitivity is limited when long-term follow-up is used as reference standard.

Original languageEnglish
Pages (from-to)875-881
Number of pages7
JournalClinical Otolaryngology
Volume43
Issue number3
DOIs
Publication statusPublished - Jun 2018

Cite this

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title = "Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma",
abstract = "OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients.DESIGN: All patients underwent 18 FDG PET/CT for the detection of distant metastases.SETTING: Retrospective single-centre study.PARTICIPANTS: Head and neck squamous cell carcinoma patients with high-risk factors for distant metastases.MAIN OUTCOME MEASURES: Accuracy of 18 FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard. Comparison of overall survival between patients diagnosed with distant metastases during initial screening and patients diagnosed with distant metastases during follow-up.RESULTS: In 23 (12{\%}) of the 190 patients, 18 FDG PET/CT detected distant metastases at screening. Sensitivity and negative predictive value were 46.2{\%} (95{\%} CI 32.6-59.7) and 82.6{\%} (95{\%} CI 76.8-88.5). No difference in median overall survival from the time of distant metastases detection was found between patients diagnosed with DM during work-up or during follow-up.CONCLUSIONS: In head and neck squamous cell carcinoma patients with high-risk factors, 18 FDG PET/CT has a high negative predictive value for the detection of distant metastases and should be used in daily clinical practice, although the sensitivity is limited when long-term follow-up is used as reference standard.",
author = "Deurvorst, {S E} and Hoekstra, {O S} and Castelijns, {J A} and Witte, {B I} and Leemans, {C R} and {de Bree}, R",
note = "{\circledC} 2018 The Authors. Clinical Otolaryngology Published by John Wiley & Sons Ltd.",
year = "2018",
month = "6",
doi = "10.1111/coa.13074",
language = "English",
volume = "43",
pages = "875--881",
journal = "Clinical Otolaryngology",
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Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma. / Deurvorst, S E; Hoekstra, O S; Castelijns, J A; Witte, B I; Leemans, C R; de Bree, R.

In: Clinical Otolaryngology, Vol. 43, No. 3, 06.2018, p. 875-881.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Clinical value of FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma

AU - Deurvorst, S E

AU - Hoekstra, O S

AU - Castelijns, J A

AU - Witte, B I

AU - Leemans, C R

AU - de Bree, R

N1 - © 2018 The Authors. Clinical Otolaryngology Published by John Wiley & Sons Ltd.

PY - 2018/6

Y1 - 2018/6

N2 - OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients.DESIGN: All patients underwent 18 FDG PET/CT for the detection of distant metastases.SETTING: Retrospective single-centre study.PARTICIPANTS: Head and neck squamous cell carcinoma patients with high-risk factors for distant metastases.MAIN OUTCOME MEASURES: Accuracy of 18 FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard. Comparison of overall survival between patients diagnosed with distant metastases during initial screening and patients diagnosed with distant metastases during follow-up.RESULTS: In 23 (12%) of the 190 patients, 18 FDG PET/CT detected distant metastases at screening. Sensitivity and negative predictive value were 46.2% (95% CI 32.6-59.7) and 82.6% (95% CI 76.8-88.5). No difference in median overall survival from the time of distant metastases detection was found between patients diagnosed with DM during work-up or during follow-up.CONCLUSIONS: In head and neck squamous cell carcinoma patients with high-risk factors, 18 FDG PET/CT has a high negative predictive value for the detection of distant metastases and should be used in daily clinical practice, although the sensitivity is limited when long-term follow-up is used as reference standard.

AB - OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients.DESIGN: All patients underwent 18 FDG PET/CT for the detection of distant metastases.SETTING: Retrospective single-centre study.PARTICIPANTS: Head and neck squamous cell carcinoma patients with high-risk factors for distant metastases.MAIN OUTCOME MEASURES: Accuracy of 18 FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard. Comparison of overall survival between patients diagnosed with distant metastases during initial screening and patients diagnosed with distant metastases during follow-up.RESULTS: In 23 (12%) of the 190 patients, 18 FDG PET/CT detected distant metastases at screening. Sensitivity and negative predictive value were 46.2% (95% CI 32.6-59.7) and 82.6% (95% CI 76.8-88.5). No difference in median overall survival from the time of distant metastases detection was found between patients diagnosed with DM during work-up or during follow-up.CONCLUSIONS: In head and neck squamous cell carcinoma patients with high-risk factors, 18 FDG PET/CT has a high negative predictive value for the detection of distant metastases and should be used in daily clinical practice, although the sensitivity is limited when long-term follow-up is used as reference standard.

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DO - 10.1111/coa.13074

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VL - 43

SP - 875

EP - 881

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

SN - 1749-4478

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ER -