Clustering of risk factors for coronary heart disease. the longitudinal relationship with lifestyle

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological CHD risk factor clustering score. This was defined as belonging to one or more gender specific 'high risk' quartiles for the following CHD risk factors: ratio between total serum cholesterol and high density lipoprotein cholesterol (TC:HDL), mean arterial blood pressure (MABP), body fatness [sum of skinfolds (SSF)], and cardiopulmonary fitness (VO2-max).

METHODS: The data were derived from the Amsterdam Growth and Health Study, an observational longitudinal study in which six repeated measurements were carried out over a period of 15 years covering adolescence and young adulthood. The longitudinal relationships were analysed with generalized estimating equations.

RESULTS: The results showed significant clustering for the TC:HDL ratio, SSF, and VO(2)-max. MABP was not significantly associated with the other CHD risk factors. Daily physical activity and alcohol consumption (only for males) were both inversely related to the clustering score. None of the other lifestyle parameters showed significant relationships with the clustering score.

CONCLUSIONS: Based on this small longitudinal study, it can be stated that during adolescence and young adulthood both daily physical activity and alcohol consumption were related to a healthy CHD risk profile.

Original languageEnglish
Pages (from-to)157-65
Number of pages9
JournalAnnals of Epidemiology
Volume11
Issue number3
Publication statusPublished - Apr 2001

Cite this

@article{97fdc1631ca04685be74c4bb38b684d4,
title = "Clustering of risk factors for coronary heart disease. the longitudinal relationship with lifestyle",
abstract = "PURPOSE: The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological CHD risk factor clustering score. This was defined as belonging to one or more gender specific 'high risk' quartiles for the following CHD risk factors: ratio between total serum cholesterol and high density lipoprotein cholesterol (TC:HDL), mean arterial blood pressure (MABP), body fatness [sum of skinfolds (SSF)], and cardiopulmonary fitness (VO2-max).METHODS: The data were derived from the Amsterdam Growth and Health Study, an observational longitudinal study in which six repeated measurements were carried out over a period of 15 years covering adolescence and young adulthood. The longitudinal relationships were analysed with generalized estimating equations.RESULTS: The results showed significant clustering for the TC:HDL ratio, SSF, and VO(2)-max. MABP was not significantly associated with the other CHD risk factors. Daily physical activity and alcohol consumption (only for males) were both inversely related to the clustering score. None of the other lifestyle parameters showed significant relationships with the clustering score.CONCLUSIONS: Based on this small longitudinal study, it can be stated that during adolescence and young adulthood both daily physical activity and alcohol consumption were related to a healthy CHD risk profile.",
keywords = "Adolescent, Adult, Alcohol Drinking, Blood Pressure/physiology, Cholesterol/blood, Cholesterol, HDL/blood, Cluster Analysis, Coronary Disease/epidemiology, Diet, Female, Follow-Up Studies, Health Behavior, Humans, Life Style, Longitudinal Studies, Male, Netherlands/epidemiology, Physical Fitness, Risk Factors, Smoking",
author = "Twisk, {J W} and Kemper, {H C} and {Van Mechelen}, W and Post, {G B}",
year = "2001",
month = "4",
language = "English",
volume = "11",
pages = "157--65",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier Inc.",
number = "3",

}

Clustering of risk factors for coronary heart disease. the longitudinal relationship with lifestyle. / Twisk, J W; Kemper, H C; Van Mechelen, W; Post, G B.

In: Annals of Epidemiology, Vol. 11, No. 3, 04.2001, p. 157-65.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Clustering of risk factors for coronary heart disease. the longitudinal relationship with lifestyle

AU - Twisk, J W

AU - Kemper, H C

AU - Van Mechelen, W

AU - Post, G B

PY - 2001/4

Y1 - 2001/4

N2 - PURPOSE: The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological CHD risk factor clustering score. This was defined as belonging to one or more gender specific 'high risk' quartiles for the following CHD risk factors: ratio between total serum cholesterol and high density lipoprotein cholesterol (TC:HDL), mean arterial blood pressure (MABP), body fatness [sum of skinfolds (SSF)], and cardiopulmonary fitness (VO2-max).METHODS: The data were derived from the Amsterdam Growth and Health Study, an observational longitudinal study in which six repeated measurements were carried out over a period of 15 years covering adolescence and young adulthood. The longitudinal relationships were analysed with generalized estimating equations.RESULTS: The results showed significant clustering for the TC:HDL ratio, SSF, and VO(2)-max. MABP was not significantly associated with the other CHD risk factors. Daily physical activity and alcohol consumption (only for males) were both inversely related to the clustering score. None of the other lifestyle parameters showed significant relationships with the clustering score.CONCLUSIONS: Based on this small longitudinal study, it can be stated that during adolescence and young adulthood both daily physical activity and alcohol consumption were related to a healthy CHD risk profile.

AB - PURPOSE: The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological CHD risk factor clustering score. This was defined as belonging to one or more gender specific 'high risk' quartiles for the following CHD risk factors: ratio between total serum cholesterol and high density lipoprotein cholesterol (TC:HDL), mean arterial blood pressure (MABP), body fatness [sum of skinfolds (SSF)], and cardiopulmonary fitness (VO2-max).METHODS: The data were derived from the Amsterdam Growth and Health Study, an observational longitudinal study in which six repeated measurements were carried out over a period of 15 years covering adolescence and young adulthood. The longitudinal relationships were analysed with generalized estimating equations.RESULTS: The results showed significant clustering for the TC:HDL ratio, SSF, and VO(2)-max. MABP was not significantly associated with the other CHD risk factors. Daily physical activity and alcohol consumption (only for males) were both inversely related to the clustering score. None of the other lifestyle parameters showed significant relationships with the clustering score.CONCLUSIONS: Based on this small longitudinal study, it can be stated that during adolescence and young adulthood both daily physical activity and alcohol consumption were related to a healthy CHD risk profile.

KW - Adolescent

KW - Adult

KW - Alcohol Drinking

KW - Blood Pressure/physiology

KW - Cholesterol/blood

KW - Cholesterol, HDL/blood

KW - Cluster Analysis

KW - Coronary Disease/epidemiology

KW - Diet

KW - Female

KW - Follow-Up Studies

KW - Health Behavior

KW - Humans

KW - Life Style

KW - Longitudinal Studies

KW - Male

KW - Netherlands/epidemiology

KW - Physical Fitness

KW - Risk Factors

KW - Smoking

M3 - Article

VL - 11

SP - 157

EP - 165

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 3

ER -