CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus)

S Amor, H E Webb

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Mice inoculated intraperitoneally with the alphavirus Semliki Forest were protected against a subsequent challenge with the flavivirus Langat. The protection was seen as a reduction in the Langat virus titres, mortality index and percentage deaths. The severity of the brain pathology was greater in the simultaneously infected mice, or when the time interval between administration of the viruses was 7 days, compared to that seen following a single infection of either Semliki Forest or Langat virus. When the time interval was greater than 14 days the severity of the histopathological lesions were reduced. Two factors were considered to be of possible importance in the protection afforded by the original alphavirus. Either persistence of the alphavirus interfering with the challenge flavivirus or cross-reactive immunity arising from a common host cell membrane derived glycolipid component present in both viral envelopes. This latter phenomenon could be important as anti-glycolipid activity present at 14 days after the first virus increased significantly after challenge with the second virus.

Original languageEnglish
Pages (from-to)197-208
Number of pages12
JournalInternational Journal of Experimental Pathology
Volume69
Issue number2
Publication statusPublished - Apr 1988

Cite this

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title = "CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus)",
abstract = "Mice inoculated intraperitoneally with the alphavirus Semliki Forest were protected against a subsequent challenge with the flavivirus Langat. The protection was seen as a reduction in the Langat virus titres, mortality index and percentage deaths. The severity of the brain pathology was greater in the simultaneously infected mice, or when the time interval between administration of the viruses was 7 days, compared to that seen following a single infection of either Semliki Forest or Langat virus. When the time interval was greater than 14 days the severity of the histopathological lesions were reduced. Two factors were considered to be of possible importance in the protection afforded by the original alphavirus. Either persistence of the alphavirus interfering with the challenge flavivirus or cross-reactive immunity arising from a common host cell membrane derived glycolipid component present in both viral envelopes. This latter phenomenon could be important as anti-glycolipid activity present at 14 days after the first virus increased significantly after challenge with the second virus.",
keywords = "Animals, Antibodies, Viral, Brain, Cross Reactions, Encephalitis Viruses, Tick-Borne, Galactosylceramides, Glycolipids, Immunoglobulin G, Mice, Semliki forest virus, Time Factors, Togaviridae Infections, Viral Interference, Journal Article, Research Support, Non-U.S. Gov't",
author = "S Amor and Webb, {H E}",
year = "1988",
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pages = "197--208",
journal = "International Journal of Experimental Pathology",
issn = "0959-9673",
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CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus). / Amor, S; Webb, H E.

In: International Journal of Experimental Pathology, Vol. 69, No. 2, 04.1988, p. 197-208.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus)

AU - Amor, S

AU - Webb, H E

PY - 1988/4

Y1 - 1988/4

N2 - Mice inoculated intraperitoneally with the alphavirus Semliki Forest were protected against a subsequent challenge with the flavivirus Langat. The protection was seen as a reduction in the Langat virus titres, mortality index and percentage deaths. The severity of the brain pathology was greater in the simultaneously infected mice, or when the time interval between administration of the viruses was 7 days, compared to that seen following a single infection of either Semliki Forest or Langat virus. When the time interval was greater than 14 days the severity of the histopathological lesions were reduced. Two factors were considered to be of possible importance in the protection afforded by the original alphavirus. Either persistence of the alphavirus interfering with the challenge flavivirus or cross-reactive immunity arising from a common host cell membrane derived glycolipid component present in both viral envelopes. This latter phenomenon could be important as anti-glycolipid activity present at 14 days after the first virus increased significantly after challenge with the second virus.

AB - Mice inoculated intraperitoneally with the alphavirus Semliki Forest were protected against a subsequent challenge with the flavivirus Langat. The protection was seen as a reduction in the Langat virus titres, mortality index and percentage deaths. The severity of the brain pathology was greater in the simultaneously infected mice, or when the time interval between administration of the viruses was 7 days, compared to that seen following a single infection of either Semliki Forest or Langat virus. When the time interval was greater than 14 days the severity of the histopathological lesions were reduced. Two factors were considered to be of possible importance in the protection afforded by the original alphavirus. Either persistence of the alphavirus interfering with the challenge flavivirus or cross-reactive immunity arising from a common host cell membrane derived glycolipid component present in both viral envelopes. This latter phenomenon could be important as anti-glycolipid activity present at 14 days after the first virus increased significantly after challenge with the second virus.

KW - Animals

KW - Antibodies, Viral

KW - Brain

KW - Cross Reactions

KW - Encephalitis Viruses, Tick-Borne

KW - Galactosylceramides

KW - Glycolipids

KW - Immunoglobulin G

KW - Mice

KW - Semliki forest virus

KW - Time Factors

KW - Togaviridae Infections

KW - Viral Interference

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

VL - 69

SP - 197

EP - 208

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

SN - 0959-9673

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ER -