TY - JOUR
T1 - Cognitive Functioning in Obstructive Lung Disease: Results from the United Kingdom Biobank
AU - Cleutjens, Fiona A. H. M.
AU - Spruit, Martijn A.
AU - Ponds, Rudolf W. H. M.
AU - Dijkstra, Jeanette B.
AU - Franssen, Frits M. E.
AU - Wouters, Emiel F. M.
AU - Janssen, Daisy J. A.
PY - 2014
Y1 - 2014
N2 - Objectives: To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. Design: An observational population-based study. Setting: This research was conducted using the United Kingdom Biobank Resource. Participants: The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. Measurements: Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. Results: Persons with OLD had significantly worse scores than persons without OLD on prospective memory [β = -0.15 (-0.22 to -0.09)], visuospatial memory [β round 1 = 0.06 (0.03-0.10)]; β round 2 = 0.09 (<0.001-0.18)), numeric short-term memory [β = -0.05 (-0.10 to <0.001)] and cognitive processing speed [β = 4.62 (1.25-8.01)] after correction for possible confounders. Impairment in prospective memory [β = 0.004 (<0.001-0.01)] and numeric short-term memory [β = 0.01 (0.003-0.01)] were weakly related to FEV1 (adjusted P < 5). Conclusions: Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment. © 2014.
AB - Objectives: To compare domains of cognitive functioning between persons with and without obstructive lung disease (OLD) and to analyze the relationship between cognitive functioning and the degree of airflow limitation. Design: An observational population-based study. Setting: This research was conducted using the United Kingdom Biobank Resource. Participants: The study population consisted of 43,039 persons with complete data on cognitive functioning and spirometry. Measurements: Cognitive functioning was compared between persons with and without OLD using linear regression analysis. The relationship between impairment in lung function and cognitive impairment was assessed among persons with OLD. Results: Persons with OLD had significantly worse scores than persons without OLD on prospective memory [β = -0.15 (-0.22 to -0.09)], visuospatial memory [β round 1 = 0.06 (0.03-0.10)]; β round 2 = 0.09 (<0.001-0.18)), numeric short-term memory [β = -0.05 (-0.10 to <0.001)] and cognitive processing speed [β = 4.62 (1.25-8.01)] after correction for possible confounders. Impairment in prospective memory [β = 0.004 (<0.001-0.01)] and numeric short-term memory [β = 0.01 (0.003-0.01)] were weakly related to FEV1 (adjusted P < 5). Conclusions: Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment. © 2014.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84893639466&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/24513227
U2 - 10.1016/j.jamda.2013.12.007
DO - 10.1016/j.jamda.2013.12.007
M3 - Article
C2 - 24513227
VL - 15
SP - 214
EP - 219
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
SN - 1525-8610
IS - 3
ER -