Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume

A. M. Wessels, S. A R B Rombouts, P. L. Remijnse, Y. Boom, P. Scheltens, F. Barkhof, R. J. Heine, F. J. Snoek

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims/hypothesis: Cognitive performance in type 1 diabetes may be compromised as a result of chronic hyperglycaemia. The aim of this study was to investigate the cognitive functioning of patients with type 1 diabetes (including a subgroup with a microvascular complication) and nondiabetic controls, and to assess the relationship between cognition and cerebral grey and white matter volumes. Materials and methods: Twenty-five patients with type 1 diabetes (of whom ten had proliferative retinopathy) and nine nondiabetic controls (matched in terms of sex, age and education) underwent a neuropsychological examination and magnetic resonance imaging of the brain. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from each participant. Results: Compared with nondiabetic controls, patients with diabetes performed worse on tests measuring speed of information processing and visuoconstruction; patients with microvascular disease performed worse on the former cognitive domain (p=0.03), whereas patients without complications performed worse on the latter domain (p=0.01). Patients with a microvascular complication had a significantly smaller white matter volume than nondiabetic controls (p=0.04), and smaller white matter volume was associated with worse performance on the domains of speed of information processing and attention and executive function. Conclusions/interpretation: Patients with diabetes demonstrated several subtle neuropsychological deficits, which were found to be related to white matter volume. Since patients with diabetic retinopathy had a smaller white matter volume, this suggests that cognitive decline is at least partly mediated by microvascular disease. This needs to be addressed in future studies.

Original languageEnglish
Pages (from-to)1763-1769
Number of pages7
JournalDiabetologia
Volume50
Issue number8
DOIs
Publication statusPublished - 1 Aug 2007

Cite this

Wessels, A. M. ; Rombouts, S. A R B ; Remijnse, P. L. ; Boom, Y. ; Scheltens, P. ; Barkhof, F. ; Heine, R. J. ; Snoek, F. J. / Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume. In: Diabetologia. 2007 ; Vol. 50, No. 8. pp. 1763-1769.
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abstract = "Aims/hypothesis: Cognitive performance in type 1 diabetes may be compromised as a result of chronic hyperglycaemia. The aim of this study was to investigate the cognitive functioning of patients with type 1 diabetes (including a subgroup with a microvascular complication) and nondiabetic controls, and to assess the relationship between cognition and cerebral grey and white matter volumes. Materials and methods: Twenty-five patients with type 1 diabetes (of whom ten had proliferative retinopathy) and nine nondiabetic controls (matched in terms of sex, age and education) underwent a neuropsychological examination and magnetic resonance imaging of the brain. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from each participant. Results: Compared with nondiabetic controls, patients with diabetes performed worse on tests measuring speed of information processing and visuoconstruction; patients with microvascular disease performed worse on the former cognitive domain (p=0.03), whereas patients without complications performed worse on the latter domain (p=0.01). Patients with a microvascular complication had a significantly smaller white matter volume than nondiabetic controls (p=0.04), and smaller white matter volume was associated with worse performance on the domains of speed of information processing and attention and executive function. Conclusions/interpretation: Patients with diabetes demonstrated several subtle neuropsychological deficits, which were found to be related to white matter volume. Since patients with diabetic retinopathy had a smaller white matter volume, this suggests that cognitive decline is at least partly mediated by microvascular disease. This needs to be addressed in future studies.",
keywords = "Cognitive performance, Grey matter volume, Microvascular disease, Type 1 diabetes, White matter volume",
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Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume. / Wessels, A. M.; Rombouts, S. A R B; Remijnse, P. L.; Boom, Y.; Scheltens, P.; Barkhof, F.; Heine, R. J.; Snoek, F. J.

In: Diabetologia, Vol. 50, No. 8, 01.08.2007, p. 1763-1769.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume

AU - Wessels, A. M.

AU - Rombouts, S. A R B

AU - Remijnse, P. L.

AU - Boom, Y.

AU - Scheltens, P.

AU - Barkhof, F.

AU - Heine, R. J.

AU - Snoek, F. J.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Aims/hypothesis: Cognitive performance in type 1 diabetes may be compromised as a result of chronic hyperglycaemia. The aim of this study was to investigate the cognitive functioning of patients with type 1 diabetes (including a subgroup with a microvascular complication) and nondiabetic controls, and to assess the relationship between cognition and cerebral grey and white matter volumes. Materials and methods: Twenty-five patients with type 1 diabetes (of whom ten had proliferative retinopathy) and nine nondiabetic controls (matched in terms of sex, age and education) underwent a neuropsychological examination and magnetic resonance imaging of the brain. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from each participant. Results: Compared with nondiabetic controls, patients with diabetes performed worse on tests measuring speed of information processing and visuoconstruction; patients with microvascular disease performed worse on the former cognitive domain (p=0.03), whereas patients without complications performed worse on the latter domain (p=0.01). Patients with a microvascular complication had a significantly smaller white matter volume than nondiabetic controls (p=0.04), and smaller white matter volume was associated with worse performance on the domains of speed of information processing and attention and executive function. Conclusions/interpretation: Patients with diabetes demonstrated several subtle neuropsychological deficits, which were found to be related to white matter volume. Since patients with diabetic retinopathy had a smaller white matter volume, this suggests that cognitive decline is at least partly mediated by microvascular disease. This needs to be addressed in future studies.

AB - Aims/hypothesis: Cognitive performance in type 1 diabetes may be compromised as a result of chronic hyperglycaemia. The aim of this study was to investigate the cognitive functioning of patients with type 1 diabetes (including a subgroup with a microvascular complication) and nondiabetic controls, and to assess the relationship between cognition and cerebral grey and white matter volumes. Materials and methods: Twenty-five patients with type 1 diabetes (of whom ten had proliferative retinopathy) and nine nondiabetic controls (matched in terms of sex, age and education) underwent a neuropsychological examination and magnetic resonance imaging of the brain. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from each participant. Results: Compared with nondiabetic controls, patients with diabetes performed worse on tests measuring speed of information processing and visuoconstruction; patients with microvascular disease performed worse on the former cognitive domain (p=0.03), whereas patients without complications performed worse on the latter domain (p=0.01). Patients with a microvascular complication had a significantly smaller white matter volume than nondiabetic controls (p=0.04), and smaller white matter volume was associated with worse performance on the domains of speed of information processing and attention and executive function. Conclusions/interpretation: Patients with diabetes demonstrated several subtle neuropsychological deficits, which were found to be related to white matter volume. Since patients with diabetic retinopathy had a smaller white matter volume, this suggests that cognitive decline is at least partly mediated by microvascular disease. This needs to be addressed in future studies.

KW - Cognitive performance

KW - Grey matter volume

KW - Microvascular disease

KW - Type 1 diabetes

KW - White matter volume

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JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

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