Collagen type V modulates fibroblast behavior dependent on substrate stiffness

R.G.M. Breuls, D.D. Klumpers, V Everts, T.H. Smit

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Collagen type V is highly expressed during tissue development and wound repair, but its exact function remains unclear. Cell binding to collagen V affects various basic cell functions and increased collagen V levels alter the structural organization and the stiffness of the ECM. We studied the combined effects of collagen V and substrate stiffness on the morphology, focal adhesion formation, and actin organization of fibroblasts. We found that a hybrid collagen I/V coating impairs fibroblast spreading on soft substrates (
Original languageUndefined/Unknown
Pages (from-to)425-429
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 2009

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