Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

Maria Themeli, Michel Sadelain

Research output: Contribution to journalArticleAcademic

Abstract

T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalTrends in Molecular Medicine
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 2016

Cite this

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title = "Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response",
abstract = "T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.",
keywords = "Animals, Cell Engineering, Humans, Immunotherapy/methods, Neoplasms/immunology, Receptors, Notch/chemistry, Signal Transduction, Synthetic Biology/methods, T-Lymphocytes/metabolism",
author = "Maria Themeli and Michel Sadelain",
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year = "2016",
month = "4",
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language = "English",
volume = "22",
pages = "271--273",
journal = "Trends in Molecular Medicine",
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Combinatorial Antigen Targeting : Ideal T-Cell Sensing and Anti-Tumor Response. / Themeli, Maria; Sadelain, Michel.

In: Trends in Molecular Medicine, Vol. 22, No. 4, 04.2016, p. 271-273.

Research output: Contribution to journalArticleAcademic

TY - JOUR

T1 - Combinatorial Antigen Targeting

T2 - Ideal T-Cell Sensing and Anti-Tumor Response

AU - Themeli, Maria

AU - Sadelain, Michel

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/4

Y1 - 2016/4

N2 - T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.

AB - T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.

KW - Animals

KW - Cell Engineering

KW - Humans

KW - Immunotherapy/methods

KW - Neoplasms/immunology

KW - Receptors, Notch/chemistry

KW - Signal Transduction

KW - Synthetic Biology/methods

KW - T-Lymphocytes/metabolism

U2 - 10.1016/j.molmed.2016.02.009

DO - 10.1016/j.molmed.2016.02.009

M3 - Article

VL - 22

SP - 271

EP - 273

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 4

ER -