This case study evaluates the COloRectal canceR distrEss reduCTion (CORRECT) intervention, a blended cognitive-behavioral therapy (bCBT) combining face-to-face (F2F) therapy with an interactive self-management website to reduce high distress in colorectal cancer survivors (CRCS). A cognitive-behavior therapist treated a 74-year-old male CRCS with bCBT for 4 months. At baseline, postintervention, and 7- and 14-months follow-up he filled in questionnaires assessing psychological distress (primary outcome Brief Symptom Inventory–18 [BSI-18]), anxiety, fatigue, fear of cancer recurrence, cancer-specific distress, self-efficacy, and quality of life. Reliable Change Indexes were used to analyze effects over time. Therapeutic alliance and intervention evaluation were assessed postintervention. An independent clinical psychologist performed a semi-structured interview 10 months from baseline. A detailed description shows the course of bCBT. Quantitative analyses showed improved postintervention psychological distress. Most secondary outcomes improved. Anxiety and cancer-specific distress remained improved during follow-ups. Therapeutic alliance and patient satisfaction were high. This study showed how a combined F2F and online intervention was successful in reducing distress of a cancer survivor. The treatment protocol appeared feasible and will be tested in a randomized controlled trial.