Common brain disorders are associated with heritable patterns of apparent aging of the brain

Tobias Kaufmann, Dennis van der Meer, Nhat Trung Doan, Emanuel Schwarz, Martina J. Lund, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur-Streubel, Alessandro Bertolino, Francesco Bettella, Mona K. Beyer, Erlend Bøen, Stefan Borgwardt, Christine L. Brandt, Jan Buitelaar, Elisabeth G. Celius, Simon Cervenka, Annette Conzelmann, Aldo Córdova-PalomeraAnders M. Dale, Dominique J. F. de Quervain, PasqualeDi Carlo, Srdjan Djurovic, Erlend S. Dørum, Sarah Eisenacher, Torbjørn Elvsåshagen, Thomas Espeseth, Helena Fatouros-Bergman, Lena Flyckt, Barbara Franke, Oleksandr Frei, Beathe Haatveit, Asta K. Håberg, Hanne F. Harbo, Catharina A. Hartman, Dirk Heslenfeld, Pieter J. Hoekstra, Einar A. Høgestøl, Terry L. Jernigan, Rune Jonassen, Erik G. Jönsson, Peter Kirsch, Iwona Kłoszewska, Knut K. Kolskår, Nils Inge Landrø, StephanieLe Hellard, Klaus-Peter Lesch, Simon Lovestone, Jaap Oosterlaan, Karolinska Schizophrenia Project (KaSP), Marco Papalino, Andreas Papassotiropoulos, Paul Pauli, Giulio Pergola, Karin Persson, Genevieve Richard, Jaroslav Rokicki, Anne-Marthe Sanders, Geir Selbæk, Alexey Shadrin, Olav B. Smeland, Hilkka Soininen, Piotr Sowa, Vidar M. Steen, Magda Tsolaki, Kristine M. Ulrichsen, Bruno Vellas, Lei Wang, Eric Westman, Georg C. Ziegler, Mathias Zink, Ole A. Andreassen, Lars T. Westlye

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Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Original languageEnglish
Pages (from-to)1617-1623
JournalNature Neuroscience
Volume22
Issue number10
DOIs
Publication statusPublished - 1 Oct 2019

Cite this

Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., ... Westlye, L. T. (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience, 22(10), 1617-1623. https://doi.org/10.1038/s41593-019-0471-7