Common brain disorders are associated with heritable patterns of apparent aging of the brain

Tobias Kaufmann; Dennis van der Meer; Nhat Trung Doan; Emanuel Schwarz; Martina J. Lund; Ingrid Agartz; Dag Alnæs; Deanna M. Barch; Ramona Baur-Streubel; Alessandro Bertolino; Francesco Bettella; Mona K. Beyer; Erlend Bøen; Stefan Borgwardt; Christine L. Brandt; Jan Buitelaar; Elisabeth G. Celius; Simon Cervenka; Annette Conzelmann; Aldo Córdova-Palomera; Anders M. Dale; Dominique J. F. de Quervain; PasqualeDi Carlo; Srdjan Djurovic; Erlend S. Dørum; Sarah Eisenacher; Torbjørn Elvsåshagen; Thomas Espeseth; Helena Fatouros-Bergman; Lena Flyckt; Barbara Franke; Oleksandr Frei; Beathe Haatveit; Asta K. Håberg; Hanne F. Harbo; Catharina A. Hartman; Dirk Heslenfeld; Pieter J. Hoekstra; Einar A. Høgestøl; Terry L. Jernigan; Rune Jonassen; Erik G. Jönsson; Peter Kirsch; Iwona Kłoszewska; Knut K. Kolskår; Nils Inge Landrø; StephanieLe Hellard; Klaus-Peter Lesch; Simon Lovestone; Jaap Oosterlaan; Karolinska Schizophrenia Project (KaSP); Marco Papalino; Andreas Papassotiropoulos; Paul Pauli; Giulio Pergola; Karin Persson; Genevieve Richard; Jaroslav Rokicki; Anne-Marthe Sanders; Geir Selbæk; Alexey Shadrin; Olav B. Smeland; Hilkka Soininen; Piotr Sowa; Vidar M. Steen; Magda Tsolaki; Kristine M. Ulrichsen; Bruno Vellas; Lei Wang; Eric Westman; Georg C. Ziegler; Mathias Zink; Ole A. Andreassen; Lars T. Westlye

doi:10.1038/s41593-019-0471-7

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Tobias Kaufmann, Dennis van der Meer, Nhat Trung Doan, Emanuel Schwarz, Martina J. Lund, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur-Streubel, Alessandro Bertolino, Francesco Bettella, Mona K. Beyer, Erlend Bøen, Stefan Borgwardt, Christine L. Brandt, Jan Buitelaar, Elisabeth G. Celius, Simon Cervenka, Annette Conzelmann, Aldo Córdova-PalomeraAnders M. Dale, Dominique J. F. de Quervain, PasqualeDi Carlo, Srdjan Djurovic, Erlend S. Dørum, Sarah Eisenacher, Torbjørn Elvsåshagen, Thomas Espeseth, Helena Fatouros-Bergman, Lena Flyckt, Barbara Franke, Oleksandr Frei, Beathe Haatveit, Asta K. Håberg, Hanne F. Harbo, Catharina A. Hartman, Dirk Heslenfeld, Pieter J. Hoekstra, Einar A. Høgestøl, Terry L. Jernigan, Rune Jonassen, Erik G. Jönsson, Peter Kirsch, Iwona Kłoszewska, Knut K. Kolskår, Nils Inge Landrø, StephanieLe Hellard, Klaus-Peter Lesch, Simon Lovestone, Jaap Oosterlaan, Karolinska Schizophrenia Project (KaSP), Marco Papalino, Andreas Papassotiropoulos, Paul Pauli, Giulio Pergola, Karin Persson, Genevieve Richard, Jaroslav Rokicki, Anne-Marthe Sanders, Geir Selbæk, Alexey Shadrin, Olav B. Smeland, Hilkka Soininen, Piotr Sowa, Vidar M. Steen, Magda Tsolaki, Kristine M. Ulrichsen, Bruno Vellas, Lei Wang, Eric Westman, Georg C. Ziegler, Mathias Zink, Ole A. Andreassen, Lars T. Westlye

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Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Original language	English
Pages (from-to)	1617-1623
Journal	Nature Neuroscience
Volume	22
Issue number	10
DOIs	https://doi.org/10.1038/s41593-019-0471-7
Publication status	Published - 1 Oct 2019

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Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Bøen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., Conzelmann, A., ... Westlye, L. T. (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience, 22(10), 1617-1623. https://doi.org/10.1038/s41593-019-0471-7

@article{55d8c1eff7d847d682758439b8d86f63,

title = "Common brain disorders are associated with heritable patterns of apparent aging of the brain",

abstract = "Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.",

author = "Tobias Kaufmann and {van der Meer}, Dennis and Doan, {Nhat Trung} and Emanuel Schwarz and Lund, {Martina J.} and Ingrid Agartz and Dag Aln{\ae}s and Barch, {Deanna M.} and Ramona Baur-Streubel and Alessandro Bertolino and Francesco Bettella and Beyer, {Mona K.} and Erlend B{\o}en and Stefan Borgwardt and Brandt, {Christine L.} and Jan Buitelaar and Celius, {Elisabeth G.} and Simon Cervenka and Annette Conzelmann and Aldo C{\'o}rdova-Palomera and Dale, {Anders M.} and {de Quervain}, {Dominique J. F.} and PasqualeDi Carlo and Srdjan Djurovic and D{\o}rum, {Erlend S.} and Sarah Eisenacher and Torbj{\o}rn Elvs{\aa}shagen and Thomas Espeseth and Helena Fatouros-Bergman and Lena Flyckt and Barbara Franke and Oleksandr Frei and Beathe Haatveit and H{\aa}berg, {Asta K.} and Harbo, {Hanne F.} and Hartman, {Catharina A.} and Dirk Heslenfeld and Hoekstra, {Pieter J.} and H{\o}gest{\o}l, {Einar A.} and Jernigan, {Terry L.} and Rune Jonassen and J{\"o}nsson, {Erik G.} and Peter Kirsch and Iwona K{\l}oszewska and Kolsk{\aa}r, {Knut K.} and Landr{\o}, {Nils Inge} and StephanieLe Hellard and Klaus-Peter Lesch and Simon Lovestone and Jaap Oosterlaan and {Karolinska Schizophrenia Project (KaSP)} and Marco Papalino and Andreas Papassotiropoulos and Paul Pauli and Giulio Pergola and Karin Persson and Genevieve Richard and Jaroslav Rokicki and Anne-Marthe Sanders and Geir Selb{\ae}k and Alexey Shadrin and Smeland, {Olav B.} and Hilkka Soininen and Piotr Sowa and Steen, {Vidar M.} and Magda Tsolaki and Ulrichsen, {Kristine M.} and Bruno Vellas and Lei Wang and Eric Westman and Ziegler, {Georg C.} and Mathias Zink and Andreassen, {Ole A.} and Westlye, {Lars T.}",

year = "2019",

month = oct,

day = "1",

doi = "10.1038/s41593-019-0471-7",

language = "English",

volume = "22",

pages = "1617--1623",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "10",

}

Kaufmann, T, van der Meer, D, Doan, NT, Schwarz, E, Lund, MJ, Agartz, I, Alnæs, D, Barch, DM, Baur-Streubel, R, Bertolino, A, Bettella, F, Beyer, MK, Bøen, E, Borgwardt, S, Brandt, CL, Buitelaar, J, Celius, EG, Cervenka, S, Conzelmann, A, Córdova-Palomera, A, Dale, AM, de Quervain, DJF, Carlo, P, Djurovic, S, Dørum, ES, Eisenacher, S, Elvsåshagen, T, Espeseth, T, Fatouros-Bergman, H, Flyckt, L, Franke, B, Frei, O, Haatveit, B, Håberg, AK, Harbo, HF, Hartman, CA, Heslenfeld, D, Hoekstra, PJ, Høgestøl, EA, Jernigan, TL, Jonassen, R, Jönsson, EG, Kirsch, P, Kłoszewska, I, Kolskår, KK, Landrø, NI, Hellard, S, Lesch, K-P, Lovestone, S, Oosterlaan, J, Karolinska Schizophrenia Project (KaSP), Papalino, M, Papassotiropoulos, A, Pauli, P, Pergola, G, Persson, K, Richard, G, Rokicki, J, Sanders, A-M, Selbæk, G, Shadrin, A, Smeland, OB, Soininen, H, Sowa, P, Steen, VM, Tsolaki, M, Ulrichsen, KM, Vellas, B, Wang, L, Westman, E, Ziegler, GC, Zink, M, Andreassen, OA & Westlye, LT 2019, 'Common brain disorders are associated with heritable patterns of apparent aging of the brain', Nature Neuroscience, vol. 22, no. 10, pp. 1617-1623. https://doi.org/10.1038/s41593-019-0471-7

TY - JOUR

T1 - Common brain disorders are associated with heritable patterns of apparent aging of the brain

AU - Kaufmann, Tobias

AU - van der Meer, Dennis

AU - Doan, Nhat Trung

AU - Schwarz, Emanuel

AU - Lund, Martina J.

AU - Agartz, Ingrid

AU - Alnæs, Dag

AU - Barch, Deanna M.

AU - Baur-Streubel, Ramona

AU - Bertolino, Alessandro

AU - Bettella, Francesco

AU - Beyer, Mona K.

AU - Bøen, Erlend

AU - Borgwardt, Stefan

AU - Brandt, Christine L.

AU - Buitelaar, Jan

AU - Celius, Elisabeth G.

AU - Cervenka, Simon

AU - Conzelmann, Annette

AU - Córdova-Palomera, Aldo

AU - Dale, Anders M.

AU - de Quervain, Dominique J. F.

AU - Carlo, PasqualeDi

AU - Djurovic, Srdjan

AU - Dørum, Erlend S.

AU - Eisenacher, Sarah

AU - Elvsåshagen, Torbjørn

AU - Espeseth, Thomas

AU - Fatouros-Bergman, Helena

AU - Flyckt, Lena

AU - Franke, Barbara

AU - Frei, Oleksandr

AU - Haatveit, Beathe

AU - Håberg, Asta K.

AU - Harbo, Hanne F.

AU - Hartman, Catharina A.

AU - Heslenfeld, Dirk

AU - Hoekstra, Pieter J.

AU - Høgestøl, Einar A.

AU - Jernigan, Terry L.

AU - Jonassen, Rune

AU - Jönsson, Erik G.

AU - Kirsch, Peter

AU - Kłoszewska, Iwona

AU - Kolskår, Knut K.

AU - Landrø, Nils Inge

AU - Hellard, StephanieLe

AU - Lesch, Klaus-Peter

AU - Lovestone, Simon

AU - Oosterlaan, Jaap

AU - Karolinska Schizophrenia Project (KaSP)

AU - Papalino, Marco

AU - Papassotiropoulos, Andreas

AU - Pauli, Paul

AU - Pergola, Giulio

AU - Persson, Karin

AU - Richard, Genevieve

AU - Rokicki, Jaroslav

AU - Sanders, Anne-Marthe

AU - Selbæk, Geir

AU - Shadrin, Alexey

AU - Smeland, Olav B.

AU - Soininen, Hilkka

AU - Sowa, Piotr

AU - Steen, Vidar M.

AU - Tsolaki, Magda

AU - Ulrichsen, Kristine M.

AU - Vellas, Bruno

AU - Wang, Lei

AU - Westman, Eric

AU - Ziegler, Georg C.

AU - Zink, Mathias

AU - Andreassen, Ole A.

AU - Westlye, Lars T.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

AB - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072625058&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31551603

U2 - 10.1038/s41593-019-0471-7

DO - 10.1038/s41593-019-0471-7

M3 - Article

C2 - 31551603

VL - 22

SP - 1617

EP - 1623

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 10

ER -

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Abstract

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