Common variants at 11p13 are associated with susceptibility to tuberculosis

Thorsten Thye, Ellis Owusu-Dabo, Fredrik O Vannberg, Reinout van Crevel, James Curtis, Edhyana Sahiratmadja, Yanina Balabanova, Christa Ehmen, Birgit Muntau, Gerd Ruge, Jürgen Sievertsen, John Gyapong, Vladyslav Nikolayevskyy, Philip C Hill, Giorgio Sirugo, Francis Drobniewski, Esther van de Vosse, Melanie Newport, Bachti Alisjahbana, Sergey Nejentsev & 4 others Tom H M Ottenhoff, Adrian V S Hill, Rolf D Horstmann, Christian G Meyer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

Original languageEnglish
Pages (from-to)257-9
Number of pages3
JournalNature Genetics
Volume44
Issue number3
DOIs
Publication statusPublished - 5 Feb 2012

Cite this

Thye, T., Owusu-Dabo, E., Vannberg, F. O., van Crevel, R., Curtis, J., Sahiratmadja, E., ... Meyer, C. G. (2012). Common variants at 11p13 are associated with susceptibility to tuberculosis. Nature Genetics, 44(3), 257-9. https://doi.org/10.1038/ng.1080
Thye, Thorsten ; Owusu-Dabo, Ellis ; Vannberg, Fredrik O ; van Crevel, Reinout ; Curtis, James ; Sahiratmadja, Edhyana ; Balabanova, Yanina ; Ehmen, Christa ; Muntau, Birgit ; Ruge, Gerd ; Sievertsen, Jürgen ; Gyapong, John ; Nikolayevskyy, Vladyslav ; Hill, Philip C ; Sirugo, Giorgio ; Drobniewski, Francis ; van de Vosse, Esther ; Newport, Melanie ; Alisjahbana, Bachti ; Nejentsev, Sergey ; Ottenhoff, Tom H M ; Hill, Adrian V S ; Horstmann, Rolf D ; Meyer, Christian G. / Common variants at 11p13 are associated with susceptibility to tuberculosis. In: Nature Genetics. 2012 ; Vol. 44, No. 3. pp. 257-9.
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title = "Common variants at 11p13 are associated with susceptibility to tuberculosis",
abstract = "After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).",
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author = "Thorsten Thye and Ellis Owusu-Dabo and Vannberg, {Fredrik O} and {van Crevel}, Reinout and James Curtis and Edhyana Sahiratmadja and Yanina Balabanova and Christa Ehmen and Birgit Muntau and Gerd Ruge and J{\"u}rgen Sievertsen and John Gyapong and Vladyslav Nikolayevskyy and Hill, {Philip C} and Giorgio Sirugo and Francis Drobniewski and {van de Vosse}, Esther and Melanie Newport and Bachti Alisjahbana and Sergey Nejentsev and Ottenhoff, {Tom H M} and Hill, {Adrian V S} and Horstmann, {Rolf D} and Meyer, {Christian G}",
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Thye, T, Owusu-Dabo, E, Vannberg, FO, van Crevel, R, Curtis, J, Sahiratmadja, E, Balabanova, Y, Ehmen, C, Muntau, B, Ruge, G, Sievertsen, J, Gyapong, J, Nikolayevskyy, V, Hill, PC, Sirugo, G, Drobniewski, F, van de Vosse, E, Newport, M, Alisjahbana, B, Nejentsev, S, Ottenhoff, THM, Hill, AVS, Horstmann, RD & Meyer, CG 2012, 'Common variants at 11p13 are associated with susceptibility to tuberculosis' Nature Genetics, vol. 44, no. 3, pp. 257-9. https://doi.org/10.1038/ng.1080

Common variants at 11p13 are associated with susceptibility to tuberculosis. / Thye, Thorsten; Owusu-Dabo, Ellis; Vannberg, Fredrik O; van Crevel, Reinout; Curtis, James; Sahiratmadja, Edhyana; Balabanova, Yanina; Ehmen, Christa; Muntau, Birgit; Ruge, Gerd; Sievertsen, Jürgen; Gyapong, John; Nikolayevskyy, Vladyslav; Hill, Philip C; Sirugo, Giorgio; Drobniewski, Francis; van de Vosse, Esther; Newport, Melanie; Alisjahbana, Bachti; Nejentsev, Sergey; Ottenhoff, Tom H M; Hill, Adrian V S; Horstmann, Rolf D; Meyer, Christian G.

In: Nature Genetics, Vol. 44, No. 3, 05.02.2012, p. 257-9.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Common variants at 11p13 are associated with susceptibility to tuberculosis

AU - Thye, Thorsten

AU - Owusu-Dabo, Ellis

AU - Vannberg, Fredrik O

AU - van Crevel, Reinout

AU - Curtis, James

AU - Sahiratmadja, Edhyana

AU - Balabanova, Yanina

AU - Ehmen, Christa

AU - Muntau, Birgit

AU - Ruge, Gerd

AU - Sievertsen, Jürgen

AU - Gyapong, John

AU - Nikolayevskyy, Vladyslav

AU - Hill, Philip C

AU - Sirugo, Giorgio

AU - Drobniewski, Francis

AU - van de Vosse, Esther

AU - Newport, Melanie

AU - Alisjahbana, Bachti

AU - Nejentsev, Sergey

AU - Ottenhoff, Tom H M

AU - Hill, Adrian V S

AU - Horstmann, Rolf D

AU - Meyer, Christian G

PY - 2012/2/5

Y1 - 2012/2/5

N2 - After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

AB - After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

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KW - Chromosomes, Human, Pair 11/genetics

KW - Cohort Studies

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Variation/genetics

KW - Genotype

KW - Ghana

KW - Humans

KW - Models, Genetic

KW - Nuclear Proteins/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Tuberculosis/genetics

U2 - 10.1038/ng.1080

DO - 10.1038/ng.1080

M3 - Article

VL - 44

SP - 257

EP - 259

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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ER -

Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E et al. Common variants at 11p13 are associated with susceptibility to tuberculosis. Nature Genetics. 2012 Feb 5;44(3):257-9. https://doi.org/10.1038/ng.1080