Common variants at 11p13 are associated with susceptibility to tuberculosis

Thorsten Thye, Ellis Owusu-Dabo, Fredrik O Vannberg, Reinout van Crevel, James Curtis, Edhyana Sahiratmadja, Yanina Balabanova, Christa Ehmen, Birgit Muntau, Gerd Ruge, Jürgen Sievertsen, John Gyapong, Vladyslav Nikolayevskyy, Philip C Hill, Giorgio Sirugo, Francis Drobniewski, Esther van de Vosse, Melanie Newport, Bachti Alisjahbana, Sergey NejentsevTom H M Ottenhoff, Adrian V S Hill, Rolf D Horstmann, Christian G Meyer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

Original languageEnglish
Pages (from-to)257-9
Number of pages3
JournalNature Genetics
Volume44
Issue number3
DOIs
Publication statusPublished - 5 Feb 2012

Cite this

Thye, T., Owusu-Dabo, E., Vannberg, F. O., van Crevel, R., Curtis, J., Sahiratmadja, E., ... Meyer, C. G. (2012). Common variants at 11p13 are associated with susceptibility to tuberculosis. Nature Genetics, 44(3), 257-9. https://doi.org/10.1038/ng.1080