Comparison of the Alzheimer's disease assessment scale cognitive subscale and the vascular dementia assessment scale in differentiating elderly individuals with different degrees of white matter changes: The ladis study

Raija Ylikoski*, Hanna Jokinen, Pia Andersen, Oili Salonen, Sofia Madureira, Jose Ferro, Frederik Barkhof, Wiesje Van Der Flier, Reinhold Schmidt, Franz Fazekas, Philip Scheltens, Gunhild Waldemar, Emilia Salvadori, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background/Aims: The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) is a widely used rating instrument. The Vascular Dementia Assessment Scale cognitive subscale (VADAS-cog) includes additional tests reflecting mental speed and executive functions. The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs). Methods:In the multicentre, multinational Leukoaraiosis and Disability in the Elderly (LADIS) study, 616 non-disabled subjects between the ages of 65 and 84 were examined using MRI, the ADAS-cog and VADAS-cog. The WMH rating from the MRI divided the patients into groups of mild (n = 280), moderate (n = 187) and severe (n = 149) degrees of change. Results: Covariance analysis controlling for the effect of age and education revealed that the ADAS-cog differentiated only the mild and severe WMH groups, while the differences between all three groups were highly significant with the VADAS-cog. Conclusions:The VADAS-cog significantly differentiated between all the white matter groups. In comparison, the ADAS-cog differentiated only severe changes. Accordingly, the VADAS-cog may be a more sensitive endpoint in studies of patients with white matter load and vascular burden of the brain.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number2
Publication statusPublished - 1 Jul 2007

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