Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

Keith Cover, Ronald van Schijndel, Bob van Dijk, Alberto Redolfi, Dirk Knol, Giovanni Battista Frisoni, Frederik Barkhof, Hugo Vrenken

Research output: Contribution to conferenceAbstractAcademic


Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB
Original languageEnglish
Publication statusPublished - 2 Aug 2011

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