Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

Keith Cover, Ronald van Schijndel, Bob van Dijk, Alberto Redolfi, Dirk Knol, Giovanni Battista Frisoni, Frederik Barkhof, Hugo Vrenken

Research output: Contribution to conferenceAbstractAcademic

Abstract

Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB
Original languageEnglish
PagesS65-S66
DOIs
Publication statusPublished - 2 Aug 2011

Cite this

@conference{4b06c47d0d8e4b9ebca43eaf46a99f20,
title = "Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs",
abstract = "Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB",
author = "Keith Cover and {van Schijndel}, Ronald and {van Dijk}, Bob and Alberto Redolfi and Dirk Knol and Frisoni, {Giovanni Battista} and Frederik Barkhof and Hugo Vrenken",
year = "2011",
month = "8",
day = "2",
doi = "10.1016/j.jalz.2011.05.158",
language = "English",
pages = "S65--S66",

}

Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs. / Cover, Keith; van Schijndel, Ronald; van Dijk, Bob; Redolfi, Alberto; Knol, Dirk; Frisoni, Giovanni Battista; Barkhof, Frederik; Vrenken, Hugo.

2011. S65-S66.

Research output: Contribution to conferenceAbstractAcademic

TY - CONF

T1 - Comparison of the back-to-back reproducibility of the Siena/FSL whole brain atrophy measurement at 3T and 1.5T using the ADNI MPRAGE MRIs

AU - Cover, Keith

AU - van Schijndel, Ronald

AU - van Dijk, Bob

AU - Redolfi, Alberto

AU - Knol, Dirk

AU - Frisoni, Giovanni Battista

AU - Barkhof, Frederik

AU - Vrenken, Hugo

PY - 2011/8/2

Y1 - 2011/8/2

N2 - Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB

AB - Background: There is substantial evidence to demonstrate that whole brain atrophy measurements perform significantly differently at 3T than1.5T [1]. MRI based measurement of atrophy, such as whole brain and hippocampus, are being used as biomarkers in diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS). Thus a comparison of their respective performances at 3T and 1.5T for planning clinical trials is needed. The aim of this study is to compare the reproducibility of the Siena/FSL whole brain atrophy measurement algorithm at the two field strengths, using back-toback( BTB) MPRAGE MRI scans from the ADNI study acquired at both 3T and 1.5T for each subject. Methods: We selected ADNI subjects who had BTB

UR - http://www.mendeley.com/research/comparison-backtoback-reproducibility-sienafsl-whole-brain-atrophy-measurement-3t-15t-using-adni-mpr

U2 - 10.1016/j.jalz.2011.05.158

DO - 10.1016/j.jalz.2011.05.158

M3 - Abstract

SP - S65-S66

ER -