Comparison of velocity- and acceleration-selective arterial spin labeling with [O]HO positron emission tomography

S Schmid, D F Heijtel, H J Mutsaerts, R Boellaard, A A Lammertsma, A J Nederveen, M J van Osch

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In the last decade spatially nonselective arterial spin labeling (SNS-ASL) methods such as velocity-selective ASL (VS-ASL) and acceleration-selective ASL have been introduced, which label spins based on their flow velocity or acceleration rather than spatial localization. Since labeling also occurs within the imaging plane, these methods suffer less from transit delay effects than traditional ASL methods. However, there is a need for validation of these techniques. In this study, a comparison was made between these SNS-ASL techniques with [15O]H2O positron emission tomography (PET), which is regarded as gold standard to measure quantitatively cerebral blood flow (CBF) in humans. In addition, the question of whether these techniques suffered from sensitivity to arterial cerebral blood volume (aCBV), as opposed to producing pure CBF contrast, was investigated. The results show high voxelwise intracranial correlation (0.72 to 0.89) between the spatial distribution of the perfusion signal from the SNS-ASL methods and the PET CBF maps. A similar gray matter (GM) CBF was measured by dual VS-ASL compared with PET (46.7+/-4.1 versus 47.1+/-6.5 mL/100 g/min, respectively). Finally, only minor contribution of aCBV patterns in GM to all SNS-ASL methods was found compared with pseudo-continuous ASL. In conclusion, VS-ASL provides a similar quantitative CBF, and all SNS-ASL methods provide qualitatively similar CBF maps as [15O]H2O PET.Journal of Cerebral Blood Flow & Metabolism advance online publication, 18 March 2015; doi:10.1038/jcbfm.2015.42
Original languageEnglish
JournalJ Cereb.Blood Flow Metab
Issue number1559-7016 (Electronic)
Publication statusPublished - 2015

Cite this

@article{a430f4e3d184446fad5f71666628edb6,
title = "Comparison of velocity- and acceleration-selective arterial spin labeling with [O]HO positron emission tomography",
abstract = "In the last decade spatially nonselective arterial spin labeling (SNS-ASL) methods such as velocity-selective ASL (VS-ASL) and acceleration-selective ASL have been introduced, which label spins based on their flow velocity or acceleration rather than spatial localization. Since labeling also occurs within the imaging plane, these methods suffer less from transit delay effects than traditional ASL methods. However, there is a need for validation of these techniques. In this study, a comparison was made between these SNS-ASL techniques with [15O]H2O positron emission tomography (PET), which is regarded as gold standard to measure quantitatively cerebral blood flow (CBF) in humans. In addition, the question of whether these techniques suffered from sensitivity to arterial cerebral blood volume (aCBV), as opposed to producing pure CBF contrast, was investigated. The results show high voxelwise intracranial correlation (0.72 to 0.89) between the spatial distribution of the perfusion signal from the SNS-ASL methods and the PET CBF maps. A similar gray matter (GM) CBF was measured by dual VS-ASL compared with PET (46.7+/-4.1 versus 47.1+/-6.5 mL/100 g/min, respectively). Finally, only minor contribution of aCBV patterns in GM to all SNS-ASL methods was found compared with pseudo-continuous ASL. In conclusion, VS-ASL provides a similar quantitative CBF, and all SNS-ASL methods provide qualitatively similar CBF maps as [15O]H2O PET.Journal of Cerebral Blood Flow & Metabolism advance online publication, 18 March 2015; doi:10.1038/jcbfm.2015.42",
keywords = "ASL, Acceleration, Blood Volume, Blood flow, Cerebral blood flow, Gray matter, Humans, MAP, MRI, Netherlands, Patterns, Perfusion, Tomography, Volume, blood, human, metabolism, methods, positron emission tomography",
author = "S Schmid and Heijtel, {D F} and Mutsaerts, {H J} and R Boellaard and Lammertsma, {A A} and Nederveen, {A J} and {van Osch}, {M J}",
year = "2015",
language = "English",
journal = "J Cereb.Blood Flow Metab",
number = "1559-7016 (Electronic)",

}

Comparison of velocity- and acceleration-selective arterial spin labeling with [O]HO positron emission tomography. / Schmid, S; Heijtel, D F; Mutsaerts, H J; Boellaard, R; Lammertsma, A A; Nederveen, A J; van Osch, M J.

In: J Cereb.Blood Flow Metab, No. 1559-7016 (Electronic), 2015.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Comparison of velocity- and acceleration-selective arterial spin labeling with [O]HO positron emission tomography

AU - Schmid, S

AU - Heijtel, D F

AU - Mutsaerts, H J

AU - Boellaard, R

AU - Lammertsma, A A

AU - Nederveen, A J

AU - van Osch, M J

PY - 2015

Y1 - 2015

N2 - In the last decade spatially nonselective arterial spin labeling (SNS-ASL) methods such as velocity-selective ASL (VS-ASL) and acceleration-selective ASL have been introduced, which label spins based on their flow velocity or acceleration rather than spatial localization. Since labeling also occurs within the imaging plane, these methods suffer less from transit delay effects than traditional ASL methods. However, there is a need for validation of these techniques. In this study, a comparison was made between these SNS-ASL techniques with [15O]H2O positron emission tomography (PET), which is regarded as gold standard to measure quantitatively cerebral blood flow (CBF) in humans. In addition, the question of whether these techniques suffered from sensitivity to arterial cerebral blood volume (aCBV), as opposed to producing pure CBF contrast, was investigated. The results show high voxelwise intracranial correlation (0.72 to 0.89) between the spatial distribution of the perfusion signal from the SNS-ASL methods and the PET CBF maps. A similar gray matter (GM) CBF was measured by dual VS-ASL compared with PET (46.7+/-4.1 versus 47.1+/-6.5 mL/100 g/min, respectively). Finally, only minor contribution of aCBV patterns in GM to all SNS-ASL methods was found compared with pseudo-continuous ASL. In conclusion, VS-ASL provides a similar quantitative CBF, and all SNS-ASL methods provide qualitatively similar CBF maps as [15O]H2O PET.Journal of Cerebral Blood Flow & Metabolism advance online publication, 18 March 2015; doi:10.1038/jcbfm.2015.42

AB - In the last decade spatially nonselective arterial spin labeling (SNS-ASL) methods such as velocity-selective ASL (VS-ASL) and acceleration-selective ASL have been introduced, which label spins based on their flow velocity or acceleration rather than spatial localization. Since labeling also occurs within the imaging plane, these methods suffer less from transit delay effects than traditional ASL methods. However, there is a need for validation of these techniques. In this study, a comparison was made between these SNS-ASL techniques with [15O]H2O positron emission tomography (PET), which is regarded as gold standard to measure quantitatively cerebral blood flow (CBF) in humans. In addition, the question of whether these techniques suffered from sensitivity to arterial cerebral blood volume (aCBV), as opposed to producing pure CBF contrast, was investigated. The results show high voxelwise intracranial correlation (0.72 to 0.89) between the spatial distribution of the perfusion signal from the SNS-ASL methods and the PET CBF maps. A similar gray matter (GM) CBF was measured by dual VS-ASL compared with PET (46.7+/-4.1 versus 47.1+/-6.5 mL/100 g/min, respectively). Finally, only minor contribution of aCBV patterns in GM to all SNS-ASL methods was found compared with pseudo-continuous ASL. In conclusion, VS-ASL provides a similar quantitative CBF, and all SNS-ASL methods provide qualitatively similar CBF maps as [15O]H2O PET.Journal of Cerebral Blood Flow & Metabolism advance online publication, 18 March 2015; doi:10.1038/jcbfm.2015.42

KW - ASL

KW - Acceleration

KW - Blood Volume

KW - Blood flow

KW - Cerebral blood flow

KW - Gray matter

KW - Humans

KW - MAP

KW - MRI

KW - Netherlands

KW - Patterns

KW - Perfusion

KW - Tomography

KW - Volume

KW - blood

KW - human

KW - metabolism

KW - methods

KW - positron emission tomography

M3 - Article

JO - J Cereb.Blood Flow Metab

JF - J Cereb.Blood Flow Metab

IS - 1559-7016 (Electronic)

ER -