Complement activation in amyloid plaques in Alzheimer's dementia

P. Eikelenboom*, C. E. Hack, J. M. Rozemuller, F. C. Stam

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Amyloid plaques in Alzheimer's dementia contain complement factors C1q, C4 and C3. In the present study we demonstrate complement activation in amyloid plaques using immunoenzymatical techniques and specific antibodies against subunits of individual complement components and activated complement products. Amyloid plaques contain C1q and activated C3 fragments (C3c and C3d, g) but no C1s and C3a. These findings demonstrate that the complement components are not passively bound to the amyloid plaque structures but are the result of an activation process. The role of complement activation in the genesis of senile plaques is discussed.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume56
Issue number1
DOIs
Publication statusPublished - 1 Dec 1988

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