Computed Tomography Observer Agreement in Staging Malignant Lymphoma

Antoinette de Jong, Thomas C Kwee, Henriëtte M E Quarles van Ufford, Frederik J A Beek, Lorentz G B A Quekel, John M H de Klerk, Josée M Zijlstra, Rob Fijnheer, Inge Ludwig, Marie José Kersten, Jaap Stoker, Rutger A J Nievelstein

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To determine pretreatment computed tomography observer agreement in patients with newly diagnosed lymphoma.

METHODS: Forty-nine computed tomography scans were reviewed by 3 experienced radiologists, with each scan assessed twice by 1 observer. Predefined nodal and extranodal regions were assessed, and Ann Arbor stages were assigned. K-statistics were defined as poor (κ < 0.2), fair (κ > 0.2 to κ ≤ 0.4), moderate (κ > 0.4 to κ ≤ 0.6), substantial (κ > 0.6 to κ ≤ 0.8), and almost perfect (κ > 0.8 to κ ≤ 1).

RESULTS: Nodal interobserver agreement varied from 0.09 for infraclavicular involvement to 0.95 for para-iliac involvement; intraobserver agreement was substantial to almost perfect, except for infraclavicular nodes. Extranodal interobserver agreement varied from 0.56 to 0.88; intraobserver agreement was substantial to almost perfect. Ann Arbor stage interobserver agreement varied from 0.57 to 0.69; intraobserver agreement was substantial.

CONCLUSION: Computed tomography observer agreement in staging malignant lymphoma appears to be suboptimal.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume40
Issue number2
DOIs
Publication statusPublished - 26 Nov 2015

Cite this

de Jong, A., Kwee, T. C., Quarles van Ufford, H. M. E., Beek, F. J. A., Quekel, L. G. B. A., de Klerk, J. M. H., ... Nievelstein, R. A. J. (2015). Computed Tomography Observer Agreement in Staging Malignant Lymphoma. Journal of Computer Assisted Tomography, 40(2), 261-265. https://doi.org/10.1097/rct.0000000000000338, https://doi.org/10.1097/RCT.0000000000000338
de Jong, Antoinette ; Kwee, Thomas C ; Quarles van Ufford, Henriëtte M E ; Beek, Frederik J A ; Quekel, Lorentz G B A ; de Klerk, John M H ; Zijlstra, Josée M ; Fijnheer, Rob ; Ludwig, Inge ; Kersten, Marie José ; Stoker, Jaap ; Nievelstein, Rutger A J. / Computed Tomography Observer Agreement in Staging Malignant Lymphoma. In: Journal of Computer Assisted Tomography. 2015 ; Vol. 40, No. 2. pp. 261-265.
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abstract = "OBJECTIVE: To determine pretreatment computed tomography observer agreement in patients with newly diagnosed lymphoma.METHODS: Forty-nine computed tomography scans were reviewed by 3 experienced radiologists, with each scan assessed twice by 1 observer. Predefined nodal and extranodal regions were assessed, and Ann Arbor stages were assigned. K-statistics were defined as poor (κ < 0.2), fair (κ > 0.2 to κ ≤ 0.4), moderate (κ > 0.4 to κ ≤ 0.6), substantial (κ > 0.6 to κ ≤ 0.8), and almost perfect (κ > 0.8 to κ ≤ 1).RESULTS: Nodal interobserver agreement varied from 0.09 for infraclavicular involvement to 0.95 for para-iliac involvement; intraobserver agreement was substantial to almost perfect, except for infraclavicular nodes. Extranodal interobserver agreement varied from 0.56 to 0.88; intraobserver agreement was substantial to almost perfect. Ann Arbor stage interobserver agreement varied from 0.57 to 0.69; intraobserver agreement was substantial.CONCLUSION: Computed tomography observer agreement in staging malignant lymphoma appears to be suboptimal.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Cohort Studies, Female, Humans, Lymph Nodes/diagnostic imaging, Lymphoma/diagnostic imaging, Male, Middle Aged, Neoplasm Staging, Observer Variation, Prospective Studies, Reproducibility of Results, Tomography, X-Ray Computed, Young Adult",
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note = "M1 - 2 ISI Document Delivery No.: DI4FF Times Cited: 0 Cited Reference Count: 20 de Jong, Antoinette Kwee, Thomas C. van Ufford, Henriette M. E. Quarles Beek, Frederik J. A. Quekel, Lorentz G. B. A. de Klerk, John M. H. Zijlstra, Josee M. Fijnheer, Rob Ludwig, Inge Kersten, Marie Jose Stoker, Jaap Nievelstein, Rutger A. J. Dutch Organization for Health Research and Development (ZonMw) Program for Health Care Efficiency Research [80-82310-98-08012]; Alpe d'HuZes/Dutch Cancer Society Bas Mulder Award [5409] Supported by the Dutch Organization for Health Research and Development (ZonMw) Program for Health Care Efficiency Research (grant number 80-82310-98-08012) and by an Alpe d'HuZes/Dutch Cancer Society Bas Mulder Award (grant number 5409) for T.C.K. Study design, data collection, data analysis, and interpretation of data, writing of the paper, and decision to submit were left to the authors' discretion and were not influenced by ZonMw or Alpe d'HuZes/Dutch Cancer Society. 0 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA J COMPUT ASSIST TOMO",
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de Jong, A, Kwee, TC, Quarles van Ufford, HME, Beek, FJA, Quekel, LGBA, de Klerk, JMH, Zijlstra, JM, Fijnheer, R, Ludwig, I, Kersten, MJ, Stoker, J & Nievelstein, RAJ 2015, 'Computed Tomography Observer Agreement in Staging Malignant Lymphoma' Journal of Computer Assisted Tomography, vol. 40, no. 2, pp. 261-265. https://doi.org/10.1097/rct.0000000000000338, https://doi.org/10.1097/RCT.0000000000000338

Computed Tomography Observer Agreement in Staging Malignant Lymphoma. / de Jong, Antoinette; Kwee, Thomas C; Quarles van Ufford, Henriëtte M E; Beek, Frederik J A; Quekel, Lorentz G B A; de Klerk, John M H; Zijlstra, Josée M; Fijnheer, Rob; Ludwig, Inge; Kersten, Marie José; Stoker, Jaap; Nievelstein, Rutger A J.

In: Journal of Computer Assisted Tomography, Vol. 40, No. 2, 26.11.2015, p. 261-265.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Computed Tomography Observer Agreement in Staging Malignant Lymphoma

AU - de Jong, Antoinette

AU - Kwee, Thomas C

AU - Quarles van Ufford, Henriëtte M E

AU - Beek, Frederik J A

AU - Quekel, Lorentz G B A

AU - de Klerk, John M H

AU - Zijlstra, Josée M

AU - Fijnheer, Rob

AU - Ludwig, Inge

AU - Kersten, Marie José

AU - Stoker, Jaap

AU - Nievelstein, Rutger A J

N1 - M1 - 2 ISI Document Delivery No.: DI4FF Times Cited: 0 Cited Reference Count: 20 de Jong, Antoinette Kwee, Thomas C. van Ufford, Henriette M. E. Quarles Beek, Frederik J. A. Quekel, Lorentz G. B. A. de Klerk, John M. H. Zijlstra, Josee M. Fijnheer, Rob Ludwig, Inge Kersten, Marie Jose Stoker, Jaap Nievelstein, Rutger A. J. Dutch Organization for Health Research and Development (ZonMw) Program for Health Care Efficiency Research [80-82310-98-08012]; Alpe d'HuZes/Dutch Cancer Society Bas Mulder Award [5409] Supported by the Dutch Organization for Health Research and Development (ZonMw) Program for Health Care Efficiency Research (grant number 80-82310-98-08012) and by an Alpe d'HuZes/Dutch Cancer Society Bas Mulder Award (grant number 5409) for T.C.K. Study design, data collection, data analysis, and interpretation of data, writing of the paper, and decision to submit were left to the authors' discretion and were not influenced by ZonMw or Alpe d'HuZes/Dutch Cancer Society. 0 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA J COMPUT ASSIST TOMO

PY - 2015/11/26

Y1 - 2015/11/26

N2 - OBJECTIVE: To determine pretreatment computed tomography observer agreement in patients with newly diagnosed lymphoma.METHODS: Forty-nine computed tomography scans were reviewed by 3 experienced radiologists, with each scan assessed twice by 1 observer. Predefined nodal and extranodal regions were assessed, and Ann Arbor stages were assigned. K-statistics were defined as poor (κ < 0.2), fair (κ > 0.2 to κ ≤ 0.4), moderate (κ > 0.4 to κ ≤ 0.6), substantial (κ > 0.6 to κ ≤ 0.8), and almost perfect (κ > 0.8 to κ ≤ 1).RESULTS: Nodal interobserver agreement varied from 0.09 for infraclavicular involvement to 0.95 for para-iliac involvement; intraobserver agreement was substantial to almost perfect, except for infraclavicular nodes. Extranodal interobserver agreement varied from 0.56 to 0.88; intraobserver agreement was substantial to almost perfect. Ann Arbor stage interobserver agreement varied from 0.57 to 0.69; intraobserver agreement was substantial.CONCLUSION: Computed tomography observer agreement in staging malignant lymphoma appears to be suboptimal.

AB - OBJECTIVE: To determine pretreatment computed tomography observer agreement in patients with newly diagnosed lymphoma.METHODS: Forty-nine computed tomography scans were reviewed by 3 experienced radiologists, with each scan assessed twice by 1 observer. Predefined nodal and extranodal regions were assessed, and Ann Arbor stages were assigned. K-statistics were defined as poor (κ < 0.2), fair (κ > 0.2 to κ ≤ 0.4), moderate (κ > 0.4 to κ ≤ 0.6), substantial (κ > 0.6 to κ ≤ 0.8), and almost perfect (κ > 0.8 to κ ≤ 1).RESULTS: Nodal interobserver agreement varied from 0.09 for infraclavicular involvement to 0.95 for para-iliac involvement; intraobserver agreement was substantial to almost perfect, except for infraclavicular nodes. Extranodal interobserver agreement varied from 0.56 to 0.88; intraobserver agreement was substantial to almost perfect. Ann Arbor stage interobserver agreement varied from 0.57 to 0.69; intraobserver agreement was substantial.CONCLUSION: Computed tomography observer agreement in staging malignant lymphoma appears to be suboptimal.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Cohort Studies

KW - Female

KW - Humans

KW - Lymph Nodes/diagnostic imaging

KW - Lymphoma/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Observer Variation

KW - Prospective Studies

KW - Reproducibility of Results

KW - Tomography, X-Ray Computed

KW - Young Adult

U2 - 10.1097/rct.0000000000000338

DO - 10.1097/rct.0000000000000338

M3 - Article

VL - 40

SP - 261

EP - 265

JO - Journal of Computer Assisted Tomography

JF - Journal of Computer Assisted Tomography

SN - 0363-8715

IS - 2

ER -