Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

Paul Cernohorsky, Simon D. Strackee, Geert J. Streekstra, Jeroen P. van den Wijngaard, Jos A. E. Spaan, Maria Siebes, Ton G. van Leeuwen, Daniel M. de Bruin

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design: Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired CT data, 3-dimensional realignment of the OCT data to the curved intraarticular trajectory was performed for all probe positions. The scanned TMC joints were processed using a cryomicrotome imaging system. Finally, cartilage thickness measurements between OCT and cryomicrotome data were compared. Results: Successful visualization of TMC articular cartilage was performed using OCT. The CT-mediated registration yielded a digital reconstruction of the articular surface on which thickness measurements could be performed. A near-perfect agreement between OCT and cryomicrotome thickness measurements was found (r2 = 0.989). Conclusion: The proposed approach enables 3D reconstruction of the TMC articular surface with subsequent accurate cartilage thickness measurements, encouraging the development of intraarticular cartilage OCT for future (clinical) application.
Original languageEnglish
JournalCartilage
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Cite this

Cernohorsky, Paul ; Strackee, Simon D. ; Streekstra, Geert J. ; van den Wijngaard, Jeroen P. ; Spaan, Jos A. E. ; Siebes, Maria ; van Leeuwen, Ton G. ; de Bruin, Daniel M. / Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study. In: Cartilage. 2019.
@article{0613db91c4b44a7ca469cae85c315abf,
title = "Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study",
abstract = "Objective: Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design: Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired CT data, 3-dimensional realignment of the OCT data to the curved intraarticular trajectory was performed for all probe positions. The scanned TMC joints were processed using a cryomicrotome imaging system. Finally, cartilage thickness measurements between OCT and cryomicrotome data were compared. Results: Successful visualization of TMC articular cartilage was performed using OCT. The CT-mediated registration yielded a digital reconstruction of the articular surface on which thickness measurements could be performed. A near-perfect agreement between OCT and cryomicrotome thickness measurements was found (r2 = 0.989). Conclusion: The proposed approach enables 3D reconstruction of the TMC articular surface with subsequent accurate cartilage thickness measurements, encouraging the development of intraarticular cartilage OCT for future (clinical) application.",
author = "Paul Cernohorsky and Strackee, {Simon D.} and Streekstra, {Geert J.} and {van den Wijngaard}, {Jeroen P.} and Spaan, {Jos A. E.} and Maria Siebes and {van Leeuwen}, {Ton G.} and {de Bruin}, {Daniel M.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/1947603519860247",
language = "English",
journal = "Cartilage",
issn = "1947-6035",

}

Cernohorsky, P, Strackee, SD, Streekstra, GJ, van den Wijngaard, JP, Spaan, JAE, Siebes, M, van Leeuwen, TG & de Bruin, DM 2019, 'Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study' Cartilage. https://doi.org/10.1177/1947603519860247

Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study. / Cernohorsky, Paul; Strackee, Simon D.; Streekstra, Geert J.; van den Wijngaard, Jeroen P.; Spaan, Jos A. E.; Siebes, Maria; van Leeuwen, Ton G.; de Bruin, Daniel M.

In: Cartilage, 01.01.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

AU - Cernohorsky, Paul

AU - Strackee, Simon D.

AU - Streekstra, Geert J.

AU - van den Wijngaard, Jeroen P.

AU - Spaan, Jos A. E.

AU - Siebes, Maria

AU - van Leeuwen, Ton G.

AU - de Bruin, Daniel M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design: Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired CT data, 3-dimensional realignment of the OCT data to the curved intraarticular trajectory was performed for all probe positions. The scanned TMC joints were processed using a cryomicrotome imaging system. Finally, cartilage thickness measurements between OCT and cryomicrotome data were compared. Results: Successful visualization of TMC articular cartilage was performed using OCT. The CT-mediated registration yielded a digital reconstruction of the articular surface on which thickness measurements could be performed. A near-perfect agreement between OCT and cryomicrotome thickness measurements was found (r2 = 0.989). Conclusion: The proposed approach enables 3D reconstruction of the TMC articular surface with subsequent accurate cartilage thickness measurements, encouraging the development of intraarticular cartilage OCT for future (clinical) application.

AB - Objective: Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design: Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired CT data, 3-dimensional realignment of the OCT data to the curved intraarticular trajectory was performed for all probe positions. The scanned TMC joints were processed using a cryomicrotome imaging system. Finally, cartilage thickness measurements between OCT and cryomicrotome data were compared. Results: Successful visualization of TMC articular cartilage was performed using OCT. The CT-mediated registration yielded a digital reconstruction of the articular surface on which thickness measurements could be performed. A near-perfect agreement between OCT and cryomicrotome thickness measurements was found (r2 = 0.989). Conclusion: The proposed approach enables 3D reconstruction of the TMC articular surface with subsequent accurate cartilage thickness measurements, encouraging the development of intraarticular cartilage OCT for future (clinical) application.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068900064&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31291745

U2 - 10.1177/1947603519860247

DO - 10.1177/1947603519860247

M3 - Article

JO - Cartilage

JF - Cartilage

SN - 1947-6035

ER -

Cernohorsky P, Strackee SD, Streekstra GJ, van den Wijngaard JP, Spaan JAE, Siebes M et al. Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study. Cartilage. 2019 Jan 1. https://doi.org/10.1177/1947603519860247

Access to Document