Les adénovirus réplicatifs conditionnels: un second souffle pour la thérapie génique du cancer

Translated title of the contribution: Conditionally replicative adenoviruses: a second wind for cancer gene therapy

Jacques Grill, Birgit Geoerger, Martine Lamfers, Clemens Dirven, Victor Van Beusechem, Winald Gerritsen, Gilles Vassal

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cancer gene therapy has offered many hopes but its first use in humans revealed some pitfalls and at least three main problems: lack of efficacy and specificity of current vectors to deliver therapeutic genes, poor diffusion of the therapeutic effects inside the tumor (absence of bystander effect), poor distribution of the vectors injected inside the tissue. To address some of these issues, several teams have developed tumor selective replicating adenoviruses, some of them being already in the clinic. First results are promising but complementary studies are needed to define if these agents will take place in the therapeutic armentorium against cancer.

Original languageFrench
Pages (from-to)1039-48
Number of pages10
JournalBulletin du cancer
Volume90
Issue number12
Publication statusPublished - Dec 2003

Cite this

Grill, J., Geoerger, B., Lamfers, M., Dirven, C., Van Beusechem, V., Gerritsen, W., & Vassal, G. (2003). Les adénovirus réplicatifs conditionnels: un second souffle pour la thérapie génique du cancer. Bulletin du cancer, 90(12), 1039-48.