Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium

Christine M. Freitag, Kerstin Konrad, Christina Stadler, Stephane A. de Brito, Arne Popma, Sabine C. Herpertz, Beate Herpertz-Dahlmann, Inga Neumann, Meinhard Kieser, Andreas G. Chiocchetti, Christina Schwenck, Graeme Fairchild

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used all-male or predominantly male samples. Although the number of females exhibiting CD has increased in recent decades, the majority of studies on neurobiological measures, neurocognitive phenotypes, and treatments for CD have focused on male subjects only, despite strong evidence for sex differences in the aetiology and neurobiology of CD. Here, we selectively review the existing literature on CD and related phenotypes in females, focusing in particular on sex differences in CD symptoms, patterns of psychiatric comorbidity, and callous–unemotional personality traits. We also consider studies investigating the neurobiology of CD in females, with a focus on studies using genetic, structural and functional neuroimaging, psychophysiological, and neuroendocrinological methods. We end the article by providing an overview of the study design of the FemNAT-CD consortium, an interdisciplinary, multi-level and multi-site study that explicitly focuses on CD in females, but which is also investigating sex differences in the causes, developmental course, and neurobiological correlates of CD.
Original languageEnglish
Pages (from-to)1077-1093
JournalEuropean Child and Adolescent Psychiatry
Volume27
Issue number9
DOIs
Publication statusPublished - 2018

Cite this

Freitag, Christine M. ; Konrad, Kerstin ; Stadler, Christina ; de Brito, Stephane A. ; Popma, Arne ; Herpertz, Sabine C. ; Herpertz-Dahlmann, Beate ; Neumann, Inga ; Kieser, Meinhard ; Chiocchetti, Andreas G. ; Schwenck, Christina ; Fairchild, Graeme. / Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium. In: European Child and Adolescent Psychiatry. 2018 ; Vol. 27, No. 9. pp. 1077-1093.
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title = "Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium",
abstract = "Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used all-male or predominantly male samples. Although the number of females exhibiting CD has increased in recent decades, the majority of studies on neurobiological measures, neurocognitive phenotypes, and treatments for CD have focused on male subjects only, despite strong evidence for sex differences in the aetiology and neurobiology of CD. Here, we selectively review the existing literature on CD and related phenotypes in females, focusing in particular on sex differences in CD symptoms, patterns of psychiatric comorbidity, and callous–unemotional personality traits. We also consider studies investigating the neurobiology of CD in females, with a focus on studies using genetic, structural and functional neuroimaging, psychophysiological, and neuroendocrinological methods. We end the article by providing an overview of the study design of the FemNAT-CD consortium, an interdisciplinary, multi-level and multi-site study that explicitly focuses on CD in females, but which is also investigating sex differences in the causes, developmental course, and neurobiological correlates of CD.",
author = "Freitag, {Christine M.} and Kerstin Konrad and Christina Stadler and {de Brito}, {Stephane A.} and Arne Popma and Herpertz, {Sabine C.} and Beate Herpertz-Dahlmann and Inga Neumann and Meinhard Kieser and Chiocchetti, {Andreas G.} and Christina Schwenck and Graeme Fairchild",
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doi = "10.1007/s00787-018-1172-6",
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Freitag, CM, Konrad, K, Stadler, C, de Brito, SA, Popma, A, Herpertz, SC, Herpertz-Dahlmann, B, Neumann, I, Kieser, M, Chiocchetti, AG, Schwenck, C & Fairchild, G 2018, 'Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium' European Child and Adolescent Psychiatry, vol. 27, no. 9, pp. 1077-1093. https://doi.org/10.1007/s00787-018-1172-6

Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium. / Freitag, Christine M.; Konrad, Kerstin; Stadler, Christina; de Brito, Stephane A.; Popma, Arne; Herpertz, Sabine C.; Herpertz-Dahlmann, Beate; Neumann, Inga; Kieser, Meinhard; Chiocchetti, Andreas G.; Schwenck, Christina; Fairchild, Graeme.

In: European Child and Adolescent Psychiatry, Vol. 27, No. 9, 2018, p. 1077-1093.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium

AU - Freitag, Christine M.

AU - Konrad, Kerstin

AU - Stadler, Christina

AU - de Brito, Stephane A.

AU - Popma, Arne

AU - Herpertz, Sabine C.

AU - Herpertz-Dahlmann, Beate

AU - Neumann, Inga

AU - Kieser, Meinhard

AU - Chiocchetti, Andreas G.

AU - Schwenck, Christina

AU - Fairchild, Graeme

PY - 2018

Y1 - 2018

N2 - Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used all-male or predominantly male samples. Although the number of females exhibiting CD has increased in recent decades, the majority of studies on neurobiological measures, neurocognitive phenotypes, and treatments for CD have focused on male subjects only, despite strong evidence for sex differences in the aetiology and neurobiology of CD. Here, we selectively review the existing literature on CD and related phenotypes in females, focusing in particular on sex differences in CD symptoms, patterns of psychiatric comorbidity, and callous–unemotional personality traits. We also consider studies investigating the neurobiology of CD in females, with a focus on studies using genetic, structural and functional neuroimaging, psychophysiological, and neuroendocrinological methods. We end the article by providing an overview of the study design of the FemNAT-CD consortium, an interdisciplinary, multi-level and multi-site study that explicitly focuses on CD in females, but which is also investigating sex differences in the causes, developmental course, and neurobiological correlates of CD.

AB - Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used all-male or predominantly male samples. Although the number of females exhibiting CD has increased in recent decades, the majority of studies on neurobiological measures, neurocognitive phenotypes, and treatments for CD have focused on male subjects only, despite strong evidence for sex differences in the aetiology and neurobiology of CD. Here, we selectively review the existing literature on CD and related phenotypes in females, focusing in particular on sex differences in CD symptoms, patterns of psychiatric comorbidity, and callous–unemotional personality traits. We also consider studies investigating the neurobiology of CD in females, with a focus on studies using genetic, structural and functional neuroimaging, psychophysiological, and neuroendocrinological methods. We end the article by providing an overview of the study design of the FemNAT-CD consortium, an interdisciplinary, multi-level and multi-site study that explicitly focuses on CD in females, but which is also investigating sex differences in the causes, developmental course, and neurobiological correlates of CD.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29948230

U2 - 10.1007/s00787-018-1172-6

DO - 10.1007/s00787-018-1172-6

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JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

SN - 1018-8827

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ER -