TY - JOUR
T1 - CONQUER
T2 - An interactive toolbox to understand functional consequences of GWAS hits
AU - Bouland, Gerard A.
AU - Beulens, Joline W. J.
AU - Nap, Joey
AU - van der Slik, Arno R.
AU - Zaldumbide, Arnaud
AU - t'Hart, Leen M.
AU - Slieker, Roderick C.
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.
PY - 2020
Y1 - 2020
N2 - Numerous large genome-wide association studies have been performed to understand the influence of genetics on traits. Many identified risk loci are in non-coding and intergenic regions, which complicates understanding how genes and their downstream pathways are influenced. An integrative data approach is required to understand the mechanism and consequences of identified risk loci. Here, we developed the R-package CONQUER. Data for SNPs of interest are acquired from static-and dynamic repositories (build GRCh38/hg38), including GTEx-Portal, Epigenomics Project, 4D genome database and genome browsers. All visualizations are fully interactive so that the user can immediately access the underlying data. CONQUER is a user-friendly tool to perform an integrative approach on multiple SNPs where risk loci are not seen as individual risk factors but rather as a network of risk factors.
AB - Numerous large genome-wide association studies have been performed to understand the influence of genetics on traits. Many identified risk loci are in non-coding and intergenic regions, which complicates understanding how genes and their downstream pathways are influenced. An integrative data approach is required to understand the mechanism and consequences of identified risk loci. Here, we developed the R-package CONQUER. Data for SNPs of interest are acquired from static-and dynamic repositories (build GRCh38/hg38), including GTEx-Portal, Epigenomics Project, 4D genome database and genome browsers. All visualizations are fully interactive so that the user can immediately access the underlying data. CONQUER is a user-friendly tool to perform an integrative approach on multiple SNPs where risk loci are not seen as individual risk factors but rather as a network of risk factors.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123224731&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33575630
U2 - 10.1093/nargab/lqaa085
DO - 10.1093/nargab/lqaa085
M3 - Article
C2 - 33575630
SN - 2631-9268
VL - 2
JO - NAR Genomics and Bioinformatics
JF - NAR Genomics and Bioinformatics
IS - 4
ER -