Consanguinity sans reproche

Leo P. Ten Kate*, Hans Scheffer, Martina C. Cornel, Joan G. van Lookeren Campagne

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In a family with two cystic fibrosis (CF) patients and consanguineous parents, DNA analysis showed that the CF in the children was not caused by homozygosity by descent, since two different mutations were involved. A formula is given for calculating the probability that parental consanguinity, if it exists, is causally related to the existence of an autosomal recessive disease in affected children.

Original languageEnglish
Pages (from-to)295-296
Number of pages2
JournalHuman Genetics
Volume86
Issue number3
DOIs
Publication statusPublished - 1 Jan 1991

Cite this

Ten Kate, L. P., Scheffer, H., Cornel, M. C., & van Lookeren Campagne, J. G. (1991). Consanguinity sans reproche. Human Genetics, 86(3), 295-296. https://doi.org/10.1007/BF00202413