Consensus guidelines for lumbar puncture in patients with neurological diseases

Sebastiaan Engelborghs, Ellis Niemantsverdriet, Hanne Struyfs, Kaj Blennow, Raf Brouns, Manuel Comabella, Irena Dujmovic, Wiesje van der Flier, Lutz Frölich, Daniela Galimberti, Sharmilee Gnanapavan, Bernhard Hemmer, Erik Hoff, Jakub Hort, Ellen Iacobaeus, Martin Ingelsson, Frank Jan de Jong, Michael Jonsson, Michael Khalil, Jens Kuhle & 18 others Alberto Lleó, Alexandre de Mendonça, José Luis Molinuevo, Guy Nagels, Claire Paquet, Lucilla Parnetti, Gerwin Roks, Pedro Rosa-Neto, Philip Scheltens, Constance Skårsgard, Erik Stomrud, Hayrettin Tumani, Pieter Jelle Visser, Anders Wallin, Bengt Winblad, Henrik Zetterberg, Flora Duits, Charlotte E. Teunissen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

Original languageEnglish
Pages (from-to)111-126
Number of pages16
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume8
DOIs
Publication statusPublished - 2017

Cite this

Engelborghs, Sebastiaan ; Niemantsverdriet, Ellis ; Struyfs, Hanne ; Blennow, Kaj ; Brouns, Raf ; Comabella, Manuel ; Dujmovic, Irena ; van der Flier, Wiesje ; Frölich, Lutz ; Galimberti, Daniela ; Gnanapavan, Sharmilee ; Hemmer, Bernhard ; Hoff, Erik ; Hort, Jakub ; Iacobaeus, Ellen ; Ingelsson, Martin ; Jan de Jong, Frank ; Jonsson, Michael ; Khalil, Michael ; Kuhle, Jens ; Lleó, Alberto ; de Mendonça, Alexandre ; Molinuevo, José Luis ; Nagels, Guy ; Paquet, Claire ; Parnetti, Lucilla ; Roks, Gerwin ; Rosa-Neto, Pedro ; Scheltens, Philip ; Skårsgard, Constance ; Stomrud, Erik ; Tumani, Hayrettin ; Visser, Pieter Jelle ; Wallin, Anders ; Winblad, Bengt ; Zetterberg, Henrik ; Duits, Flora ; Teunissen, Charlotte E. / Consensus guidelines for lumbar puncture in patients with neurological diseases. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2017 ; Vol. 8. pp. 111-126.
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title = "Consensus guidelines for lumbar puncture in patients with neurological diseases",
abstract = "Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.",
keywords = "Back pain, Cerebrospinal fluid, Consensus guidelines, Evidence-based guidelines, Headache, Lumbar puncture, Post-LP complications",
author = "Sebastiaan Engelborghs and Ellis Niemantsverdriet and Hanne Struyfs and Kaj Blennow and Raf Brouns and Manuel Comabella and Irena Dujmovic and {van der Flier}, Wiesje and Lutz Fr{\"o}lich and Daniela Galimberti and Sharmilee Gnanapavan and Bernhard Hemmer and Erik Hoff and Jakub Hort and Ellen Iacobaeus and Martin Ingelsson and {Jan de Jong}, Frank and Michael Jonsson and Michael Khalil and Jens Kuhle and Alberto Lle{\'o} and {de Mendon{\cc}a}, Alexandre and Molinuevo, {Jos{\'e} Luis} and Guy Nagels and Claire Paquet and Lucilla Parnetti and Gerwin Roks and Pedro Rosa-Neto and Philip Scheltens and Constance Sk{\aa}rsgard and Erik Stomrud and Hayrettin Tumani and Visser, {Pieter Jelle} and Anders Wallin and Bengt Winblad and Henrik Zetterberg and Flora Duits and Teunissen, {Charlotte E.}",
year = "2017",
doi = "10.1016/j.dadm.2017.04.007",
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volume = "8",
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journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",
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Engelborghs, S, Niemantsverdriet, E, Struyfs, H, Blennow, K, Brouns, R, Comabella, M, Dujmovic, I, van der Flier, W, Frölich, L, Galimberti, D, Gnanapavan, S, Hemmer, B, Hoff, E, Hort, J, Iacobaeus, E, Ingelsson, M, Jan de Jong, F, Jonsson, M, Khalil, M, Kuhle, J, Lleó, A, de Mendonça, A, Molinuevo, JL, Nagels, G, Paquet, C, Parnetti, L, Roks, G, Rosa-Neto, P, Scheltens, P, Skårsgard, C, Stomrud, E, Tumani, H, Visser, PJ, Wallin, A, Winblad, B, Zetterberg, H, Duits, F & Teunissen, CE 2017, 'Consensus guidelines for lumbar puncture in patients with neurological diseases' Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 8, pp. 111-126. https://doi.org/10.1016/j.dadm.2017.04.007

Consensus guidelines for lumbar puncture in patients with neurological diseases. / Engelborghs, Sebastiaan; Niemantsverdriet, Ellis; Struyfs, Hanne; Blennow, Kaj; Brouns, Raf; Comabella, Manuel; Dujmovic, Irena; van der Flier, Wiesje; Frölich, Lutz; Galimberti, Daniela; Gnanapavan, Sharmilee; Hemmer, Bernhard; Hoff, Erik; Hort, Jakub; Iacobaeus, Ellen; Ingelsson, Martin; Jan de Jong, Frank; Jonsson, Michael; Khalil, Michael; Kuhle, Jens; Lleó, Alberto; de Mendonça, Alexandre; Molinuevo, José Luis; Nagels, Guy; Paquet, Claire; Parnetti, Lucilla; Roks, Gerwin; Rosa-Neto, Pedro; Scheltens, Philip; Skårsgard, Constance; Stomrud, Erik; Tumani, Hayrettin; Visser, Pieter Jelle; Wallin, Anders; Winblad, Bengt; Zetterberg, Henrik; Duits, Flora; Teunissen, Charlotte E.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 8, 2017, p. 111-126.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Consensus guidelines for lumbar puncture in patients with neurological diseases

AU - Engelborghs, Sebastiaan

AU - Niemantsverdriet, Ellis

AU - Struyfs, Hanne

AU - Blennow, Kaj

AU - Brouns, Raf

AU - Comabella, Manuel

AU - Dujmovic, Irena

AU - van der Flier, Wiesje

AU - Frölich, Lutz

AU - Galimberti, Daniela

AU - Gnanapavan, Sharmilee

AU - Hemmer, Bernhard

AU - Hoff, Erik

AU - Hort, Jakub

AU - Iacobaeus, Ellen

AU - Ingelsson, Martin

AU - Jan de Jong, Frank

AU - Jonsson, Michael

AU - Khalil, Michael

AU - Kuhle, Jens

AU - Lleó, Alberto

AU - de Mendonça, Alexandre

AU - Molinuevo, José Luis

AU - Nagels, Guy

AU - Paquet, Claire

AU - Parnetti, Lucilla

AU - Roks, Gerwin

AU - Rosa-Neto, Pedro

AU - Scheltens, Philip

AU - Skårsgard, Constance

AU - Stomrud, Erik

AU - Tumani, Hayrettin

AU - Visser, Pieter Jelle

AU - Wallin, Anders

AU - Winblad, Bengt

AU - Zetterberg, Henrik

AU - Duits, Flora

AU - Teunissen, Charlotte E.

PY - 2017

Y1 - 2017

N2 - Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

AB - Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

KW - Back pain

KW - Cerebrospinal fluid

KW - Consensus guidelines

KW - Evidence-based guidelines

KW - Headache

KW - Lumbar puncture

KW - Post-LP complications

UR - http://www.scopus.com/inward/record.url?scp=85020024963&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2017.04.007

DO - 10.1016/j.dadm.2017.04.007

M3 - Article

VL - 8

SP - 111

EP - 126

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

SN - 2352-8729

ER -