TY - JOUR
T1 - Consensus statements on PSMA PET/CT response assessment criteria in prostate cancer
AU - Fanti, Stefano
AU - Goffin, Karolien
AU - Hadaschik, Boris A
AU - Herrmann, Ken
AU - Maurer, Tobias
AU - MacLennan, Steven
AU - Oprea-Lager, Daniela E
AU - Oyen, Wim Jg
AU - Rouvière, Olivier
AU - Mottet, Nicolas
AU - Bjartell, Anders
N1 - Funding Information:
The authors acknowledge John William Bean PhD (Bean Medical Writing, Halle, Belgium, and funded by EAU Research Foundation) for providing medical writing services and Wim Witjes MD PhD (Scientific and Clinical Research Director EAU Research Foundation) and Emily Spieker (Management Assistant, European Association of Urology) for project management.
Funding Information:
The authors acknowledge John William Bean PhD (Bean Medical Writing, Halle, Belgium, and funded by EAU Research Foundation) for providing medical writing services and Wim Witjes MD PhD (Scientific and Clinical Research Director EAU Research Foundation) and Emily Spieker (Management Assistant, European Association of Urology) for project management.
Funding Information:
Stefano Fanti reports personal fees from ANMI, Astellas, Bayer, BlueEarth Diagnostics, GE Healthcare, Janssen, Novartis, and Sofie Biosciences, and non-financial support from AAA, Bayer, GE Healthcare, Curium, Tema Sinergie, Sanofi, Telix, outside the submitted work; Karolien Goffin reports personal fees from Bayer, Blue Earth Diagnostics, GE Healthcare, and Lightpoint Medical, outside the submitted work; Boris Hadaschik reports personal fees from ABX, Bayer, Lightpoint Medical, Inc., Janssen R&D, Bristol-Myers-Squibb, and Astellas; research funding from Profound Medical, German Cancer Aid, German Research Foundation, Janssen R&D, Bristol-Myers-Squibb, MSD, Pfizer, and Astellas; and travel from AstraZeneca, Janssen R&D, and Astellas; Ken Herrmann reports personal fees from Bayer, other from Sofie Biosciences, personal fees from SIRTEX, non-financial support from ABX, personal fees from Adacap, personal fees from Curium, personal fees from Endocyte, grants and personal fees from BTG, personal fees from IPSEN, personal fees from Siemens Healthineers, personal fees from GE Healthcare, personal fees from Amgen, personal fees from Novartis, and personal fees from Y-mAbs, outside the submitted work; Tobias Maurer reports personal fees from Astellas, Bayer, BlueEarth Diagnostics, Janssen Cilag ROTOP, Phillips, and grants from Acelity, outside the submitted work; Steven MacLennan reports no conflicts of interest; Daniela Oprea-Lager has no personal fees to report, except for the unrestricted grant received from Janssen for the one-day EAU/EANM PSMA PET/CT Response Assessment Criteria meeting; Wim JG Oyen has no personal fees to report, except for the unrestricted grant received from Janssen for the one-day EAU/EANM PSMA PET/CT Response Assessment Criteria meeting; OR reports personal fees from Takeda and an unrestricted grant from Janssen for the one-day EAU/EANM SMA PET/CT Response Assessment Criteria meeting; NM reports personal fees as advisor with Astellas, Jansen, BMS, Bayer, IPSEN, Ferring, Sanofi, and Steba; Anders Bjartell reports personal fees from Astellas, Bayer, Ferring, IPSEN, and Janssen, and institutional research grants from Astellas and Ferring, outside the submitted work.
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - PURPOSE: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urology met on February 21, 2020, in Amsterdam, The Netherlands, to formulate criteria for PSMA PET/CT-based response in patients treated for metastatic PCa and optimal timing to use it.METHODS: Panelists received thematic topics and relevant literature prior to the meeting. Statements on how to interpret response and progression on therapy in PCa with PSMA PET/CT and when to use it were developed. Panelists voted anonymously on a nine-point scale, ranging from strongly disagree (1) to strongly agree (9). Median scores described agreement and consensus.RESULTS: PSMA PET/CT consensus statements concerned utility, best timing for performing, criteria for evaluation of response, patients who could benefit, and handling of radiolabeled PSMA PET tracers. Consensus was reached on all statements. PSMA PET/CT can be used before and after any local and systemic treatment in patients with metastatic disease to evaluate response to treatment. Ideally, PSMA PET/CT imaging criteria should categorize patients as responders, patients with stable disease, partial response, and complete response, or as non-responders. Specific clinical scenarios such as oligometastatic or polymetastatic disease deserve special consideration.CONCLUSIONS: Adoption of PSMA PET/CT should be supported by indication for appropriate use and precise criteria for interpretation. PSMA PET/CT criteria should categorize patients as responders or non-responders. Specific clinical scenarios deserve special consideration.
AB - PURPOSE: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urology met on February 21, 2020, in Amsterdam, The Netherlands, to formulate criteria for PSMA PET/CT-based response in patients treated for metastatic PCa and optimal timing to use it.METHODS: Panelists received thematic topics and relevant literature prior to the meeting. Statements on how to interpret response and progression on therapy in PCa with PSMA PET/CT and when to use it were developed. Panelists voted anonymously on a nine-point scale, ranging from strongly disagree (1) to strongly agree (9). Median scores described agreement and consensus.RESULTS: PSMA PET/CT consensus statements concerned utility, best timing for performing, criteria for evaluation of response, patients who could benefit, and handling of radiolabeled PSMA PET tracers. Consensus was reached on all statements. PSMA PET/CT can be used before and after any local and systemic treatment in patients with metastatic disease to evaluate response to treatment. Ideally, PSMA PET/CT imaging criteria should categorize patients as responders, patients with stable disease, partial response, and complete response, or as non-responders. Specific clinical scenarios such as oligometastatic or polymetastatic disease deserve special consideration.CONCLUSIONS: Adoption of PSMA PET/CT should be supported by indication for appropriate use and precise criteria for interpretation. PSMA PET/CT criteria should categorize patients as responders or non-responders. Specific clinical scenarios deserve special consideration.
KW - Monitoring
KW - Oligometastatic prostate cancer
KW - PERCIST
KW - PET/CT
KW - PSMA ligand
KW - Polymetastatic prostate cancer
KW - Prostate cancer
KW - Prostate-specific membrane antigen (PSMA)
KW - RECIST
UR - http://www.scopus.com/inward/record.url?scp=85087447530&partnerID=8YFLogxK
U2 - 10.1007/s00259-020-04934-4
DO - 10.1007/s00259-020-04934-4
M3 - Article
C2 - 32617640
VL - 48
SP - 469
EP - 476
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
SN - 1619-7070
IS - 2
ER -