Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis

Lonneke A. van Vught, Fabrice Uhel, Chao Ding, Cees van‘t Veer, Brendon P. Scicluna, Hessel Peters-Sengers, Peter M. C. Klein Klouwenberg, Peter Nürnberg, Olaf L. Cremer, the MARS consortium, Marcus J. Schultz, Tom van der Poll*, Friso M. de Beer, Lieuwe D. J. Bos, Gerie J. Glas, Arie J. Hoogendijk, Roosmarijn T. M. van Hooijdonk, Janneke Horn, Mischa A. Huson, Laura R. A. SchoutenBrendon P. Scicluna, Marleen Straat, Lonneke A. van Vught, Luuk Wieske, Maryse A. Wiewel, Esther Witteveen, Marc J. M. Bonten, Olaf M. Cremer, David S. Y. Ong, Jos F. Frencken, Peter M. C. Klein Klouwenberg, Maria E. Koster-Brouwer, Kirsten van de Groep, Diana M. Verboom

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: A prolonged prothrombin time (PT) is a common feature in sepsis indicating consumptive coagulopathy. Objectives: To determine the association between a prolonged PT and aberrations in other host response mechanisms in sepsis. Methods: Patients admitted to the intensive care unit with sepsis were divided in quartiles according to the highest PT value measured within 24 h after admission. The host response was evaluated by measuring 19 plasma biomarkers reflecting pathways implicated in sepsis pathogenesis and by blood leukocyte gene expression profiling. Measurements and Main Results: Of 1524 admissions for sepsis, 386 (25.3%) involved patients with a normal PT (≤12.7 s); the remaining quartiles entailed 379 (24.9%) patients with a slightly prolonged PT (12.8 ≤ PT ≤ 15.0 s), 383 (25.1%) with an intermediately prolonged PT (15.1 ≤ PT ≤ 17.2 s), and 376 (24.7%) with an extremely prolonged PT (≥17.3 s). While patients with an extremely prolonged PT showed an increased crude mortality up to 1 year after admission, none of the prolonged PT groups was independently associated with 30-day adjusted mortality. Comparison of the host response between patients with a normal PT or an extremely prolonged PT matched for baseline characteristics including severity of disease showed that an extremely prolonged PT was associated with impaired anticoagulant mechanisms, a more disturbed endothelial barrier integrity and increased systemic inflammation, and blood leukocyte transcriptomes indicating more prominent metabolic reprogramming and protein catabolism. Conclusion: A prolonged PT is associated with stronger anomalies in pathways implicated in the pathogenesis of sepsis, suggesting that activation of coagulation impacts other host response mechanisms.
Original languageEnglish
Pages (from-to)1049-1063
Number of pages15
JournalJournal of Thrombosis and Haemostasis
Issue number4
Publication statusPublished - 1 Apr 2021

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