Contact heat evoked potentials: Normal values and use in small-fiber neuropathy

Vera Lagerburg, Mayienne Bakkers*, Anne Bouwhuis, Janneke G.J. Hoeijmakers, Arjen M. Smit, Sofia J.M. Van Den Berg, Ineke Hordijk-De Boer, Mardien D.G. Brouwer-Van Der Lee, Douwe Kranendonk, Jos P.H. Reulen, Catharina G. Faber, Ingemar S.J. Merkies

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N2 and P2 latencies and N2-P2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN.

Original languageEnglish
Pages (from-to)743-749
Number of pages7
JournalMuscle and Nerve
Volume51
Issue number5
DOIs
Publication statusPublished - 1 Jan 2015

Cite this

Lagerburg, V., Bakkers, M., Bouwhuis, A., Hoeijmakers, J. G. J., Smit, A. M., Van Den Berg, S. J. M., ... Merkies, I. S. J. (2015). Contact heat evoked potentials: Normal values and use in small-fiber neuropathy. Muscle and Nerve, 51(5), 743-749. https://doi.org/10.1002/mus.24465