Van doorontwikkeling van een geneesmiddel tot registratie-uitbreiding

Translated title of the contribution: Continued development of drugs: the path of thioguanine

Research output: Contribution to journalArticleProfessional


Continued development of existing drugs ('drug rediscovery') may offer new therapeutic options and be cost-effective. Rediscovered drugs are commonly prescribed off-label, although licensing can be important to allow safe and controlled prescription of the drugs to patients. Licensing of a new indication for a generic drug, however, is a complicated process since there is no blueprint for this and there is little interest from the pharmaceutical industry due to an unattractive cost-recovery model. In this article, we illustrate the successful license-extension for thioguanine - initially developed in 1950 for leukaemia - as a new treatment for patients with inflammatory bowel disease.

Translated title of the contributionContinued development of drugs: the path of thioguanine
Original languageDutch
Pages (from-to)D1757
JournalNederlands Tijdschrift voor Geneeskunde
Issue number0
Publication statusPublished - 2018

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