Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values

Robert Hemke, J. Merlijn van den Berg, Charlotte M. Nusman, E. Charlotte van Gulik, Anouk M. Barendregt, Dieneke Schonenberg-Meinema, Koert M. Dolman, Taco W. Kuijpers, Mario Maas

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: To define normative standards for the knee in healthy children using contrast-enhanced MRI, focusing on normal synovial membrane thickness. Secondly, presence of joint fluid and bone marrow oedema was evaluated. Methods: For this study, children without disorders potentially resulting in (accompanying) arthritis were included. Patients underwent clinical assessments, followed by contrast-enhanced MRI. MRI features were evaluated in consensus using the Juvenile Arthritis MRI Scoring (JAMRIS) system. Additionally, the presence of joint fluid was evaluated. No cartilage lesions or bone abnormalities were observed. Results: We included 57 healthy children. The overall mean thickness of the normal synovial membrane was 0.4 mm (min–max; 0.0–1.8mm). The synovium was thickest around the cruciate ligaments and retropatellar and suprapatellar regions. The mean overall diameter of the largest pocket of joint fluid was 2.8 mm (min–max; 0.9–8.0mm). Bone marrow changes were observed in three children (all in the apex patellae). Conclusions: The normal synovial membrane was maximally 1.8 mm thick, indicating that the JAMRIS cut-off value of 2 mm can be considered a valid measure for evaluating synovial hypertrophy. Some joint fluid and bone marrow changes suggestive of bone marrow oedema in the apex patellae can be seen in healthy children. Key Points: • Knowledge on the normal synovial appearance using contrast-enhanced MR is lacking. • In healthy children, normal synovial membrane is maximally 1.8 mm thick. • Normal synovium is thickest around the cruciate ligaments, retropatellar and suprapatellar. • Bone marrow oedema in the apex patellae is seen in healthy children.
Original languageEnglish
Pages (from-to)1167-1174
JournalEuropean Radiology
Volume28
Issue number3
DOIs
Publication statusPublished - 2018
Externally publishedYes

Cite this

Hemke, R., van den Berg, J. M., Nusman, C. M., van Gulik, E. C., Barendregt, A. M., Schonenberg-Meinema, D., ... Maas, M. (2018). Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values. European Radiology, 28(3), 1167-1174. https://doi.org/10.1007/s00330-017-5067-6
Hemke, Robert ; van den Berg, J. Merlijn ; Nusman, Charlotte M. ; van Gulik, E. Charlotte ; Barendregt, Anouk M. ; Schonenberg-Meinema, Dieneke ; Dolman, Koert M. ; Kuijpers, Taco W. ; Maas, Mario. / Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values. In: European Radiology. 2018 ; Vol. 28, No. 3. pp. 1167-1174.
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title = "Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values",
abstract = "Objectives: To define normative standards for the knee in healthy children using contrast-enhanced MRI, focusing on normal synovial membrane thickness. Secondly, presence of joint fluid and bone marrow oedema was evaluated. Methods: For this study, children without disorders potentially resulting in (accompanying) arthritis were included. Patients underwent clinical assessments, followed by contrast-enhanced MRI. MRI features were evaluated in consensus using the Juvenile Arthritis MRI Scoring (JAMRIS) system. Additionally, the presence of joint fluid was evaluated. No cartilage lesions or bone abnormalities were observed. Results: We included 57 healthy children. The overall mean thickness of the normal synovial membrane was 0.4 mm (min–max; 0.0–1.8mm). The synovium was thickest around the cruciate ligaments and retropatellar and suprapatellar regions. The mean overall diameter of the largest pocket of joint fluid was 2.8 mm (min–max; 0.9–8.0mm). Bone marrow changes were observed in three children (all in the apex patellae). Conclusions: The normal synovial membrane was maximally 1.8 mm thick, indicating that the JAMRIS cut-off value of 2 mm can be considered a valid measure for evaluating synovial hypertrophy. Some joint fluid and bone marrow changes suggestive of bone marrow oedema in the apex patellae can be seen in healthy children. Key Points: • Knowledge on the normal synovial appearance using contrast-enhanced MR is lacking. • In healthy children, normal synovial membrane is maximally 1.8 mm thick. • Normal synovium is thickest around the cruciate ligaments, retropatellar and suprapatellar. • Bone marrow oedema in the apex patellae is seen in healthy children.",
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Hemke, R, van den Berg, JM, Nusman, CM, van Gulik, EC, Barendregt, AM, Schonenberg-Meinema, D, Dolman, KM, Kuijpers, TW & Maas, M 2018, 'Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values' European Radiology, vol. 28, no. 3, pp. 1167-1174. https://doi.org/10.1007/s00330-017-5067-6

Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values. / Hemke, Robert; van den Berg, J. Merlijn; Nusman, Charlotte M.; van Gulik, E. Charlotte; Barendregt, Anouk M.; Schonenberg-Meinema, Dieneke; Dolman, Koert M.; Kuijpers, Taco W.; Maas, Mario.

In: European Radiology, Vol. 28, No. 3, 2018, p. 1167-1174.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values

AU - Hemke, Robert

AU - van den Berg, J. Merlijn

AU - Nusman, Charlotte M.

AU - van Gulik, E. Charlotte

AU - Barendregt, Anouk M.

AU - Schonenberg-Meinema, Dieneke

AU - Dolman, Koert M.

AU - Kuijpers, Taco W.

AU - Maas, Mario

PY - 2018

Y1 - 2018

N2 - Objectives: To define normative standards for the knee in healthy children using contrast-enhanced MRI, focusing on normal synovial membrane thickness. Secondly, presence of joint fluid and bone marrow oedema was evaluated. Methods: For this study, children without disorders potentially resulting in (accompanying) arthritis were included. Patients underwent clinical assessments, followed by contrast-enhanced MRI. MRI features were evaluated in consensus using the Juvenile Arthritis MRI Scoring (JAMRIS) system. Additionally, the presence of joint fluid was evaluated. No cartilage lesions or bone abnormalities were observed. Results: We included 57 healthy children. The overall mean thickness of the normal synovial membrane was 0.4 mm (min–max; 0.0–1.8mm). The synovium was thickest around the cruciate ligaments and retropatellar and suprapatellar regions. The mean overall diameter of the largest pocket of joint fluid was 2.8 mm (min–max; 0.9–8.0mm). Bone marrow changes were observed in three children (all in the apex patellae). Conclusions: The normal synovial membrane was maximally 1.8 mm thick, indicating that the JAMRIS cut-off value of 2 mm can be considered a valid measure for evaluating synovial hypertrophy. Some joint fluid and bone marrow changes suggestive of bone marrow oedema in the apex patellae can be seen in healthy children. Key Points: • Knowledge on the normal synovial appearance using contrast-enhanced MR is lacking. • In healthy children, normal synovial membrane is maximally 1.8 mm thick. • Normal synovium is thickest around the cruciate ligaments, retropatellar and suprapatellar. • Bone marrow oedema in the apex patellae is seen in healthy children.

AB - Objectives: To define normative standards for the knee in healthy children using contrast-enhanced MRI, focusing on normal synovial membrane thickness. Secondly, presence of joint fluid and bone marrow oedema was evaluated. Methods: For this study, children without disorders potentially resulting in (accompanying) arthritis were included. Patients underwent clinical assessments, followed by contrast-enhanced MRI. MRI features were evaluated in consensus using the Juvenile Arthritis MRI Scoring (JAMRIS) system. Additionally, the presence of joint fluid was evaluated. No cartilage lesions or bone abnormalities were observed. Results: We included 57 healthy children. The overall mean thickness of the normal synovial membrane was 0.4 mm (min–max; 0.0–1.8mm). The synovium was thickest around the cruciate ligaments and retropatellar and suprapatellar regions. The mean overall diameter of the largest pocket of joint fluid was 2.8 mm (min–max; 0.9–8.0mm). Bone marrow changes were observed in three children (all in the apex patellae). Conclusions: The normal synovial membrane was maximally 1.8 mm thick, indicating that the JAMRIS cut-off value of 2 mm can be considered a valid measure for evaluating synovial hypertrophy. Some joint fluid and bone marrow changes suggestive of bone marrow oedema in the apex patellae can be seen in healthy children. Key Points: • Knowledge on the normal synovial appearance using contrast-enhanced MR is lacking. • In healthy children, normal synovial membrane is maximally 1.8 mm thick. • Normal synovium is thickest around the cruciate ligaments, retropatellar and suprapatellar. • Bone marrow oedema in the apex patellae is seen in healthy children.

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Hemke R, van den Berg JM, Nusman CM, van Gulik EC, Barendregt AM, Schonenberg-Meinema D et al. Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values. European Radiology. 2018;28(3):1167-1174. https://doi.org/10.1007/s00330-017-5067-6