TY - JOUR
T1 - Contrast Media in Time-Resolved MRA at 3T
T2 - A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs
AU - Hadizadeh, Dariusch Reza
AU - Keil, Vera Catharina
AU - Jost, Gregor
AU - Pietsch, Hubertus
AU - Weibrecht, Martin
AU - Marx, Christian
AU - Willinek, Winfried
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2018/8
Y1 - 2018/8
N2 - PURPOSE: Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and half-dose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs.MATERIALS AND METHODS: 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37 s rotation time) and transverse 4D-MRA (0.3 s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3 s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters.RESULTS: In dCT (transverse 4D-MRA) hGb showed 39.0 % (14.5 %) lower arterial peak gadolinium concentrations (peak SIs) and 20.6 % (33.8 %) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb.CONCLUSION: Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multi-phase 4D-MRA.KEY POINTS: · Standard-dose gadobutrol offers high vascular gadolinium concentrations and 4D-MRA peak signals.. · Absolute vascular gadolinium concentrations and 4D-MRA peak signal intensities at 3 T diverge.. · Peak plateaus or reversals cause decreased arterial 4D-MRA peak signals at 3 T.. · Arterial image quality is rated similarly high using different contrast agent protocols.. · Venous vessel visibility in 4D-MRA is significantly better using standard dose gadobutrol..CITATION FORMAT: · Hadizadeh DR, Keil VC, Jost G et al. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Fortschr Röntgenstr 2018; 190: 747 - 757.
AB - PURPOSE: Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and half-dose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs.MATERIALS AND METHODS: 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37 s rotation time) and transverse 4D-MRA (0.3 s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3 s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters.RESULTS: In dCT (transverse 4D-MRA) hGb showed 39.0 % (14.5 %) lower arterial peak gadolinium concentrations (peak SIs) and 20.6 % (33.8 %) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb.CONCLUSION: Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multi-phase 4D-MRA.KEY POINTS: · Standard-dose gadobutrol offers high vascular gadolinium concentrations and 4D-MRA peak signals.. · Absolute vascular gadolinium concentrations and 4D-MRA peak signal intensities at 3 T diverge.. · Peak plateaus or reversals cause decreased arterial 4D-MRA peak signals at 3 T.. · Arterial image quality is rated similarly high using different contrast agent protocols.. · Venous vessel visibility in 4D-MRA is significantly better using standard dose gadobutrol..CITATION FORMAT: · Hadizadeh DR, Keil VC, Jost G et al. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Fortschr Röntgenstr 2018; 190: 747 - 757.
KW - Animals
KW - Aorta/diagnostic imaging
KW - Contrast Media/administration & dosage
KW - Dose-Response Relationship, Drug
KW - Evaluation Studies as Topic
KW - Female
KW - Gadolinium DTPA/administration & dosage
KW - Image Enhancement/methods
KW - Image Interpretation, Computer-Assisted
KW - Magnetic Resonance Angiography/methods
KW - Male
KW - Organometallic Compounds/administration & dosage
KW - Qualitative Research
KW - Swine
KW - Swine, Miniature
KW - Time Factors
KW - Tomography, X-Ray Computed
U2 - 10.1055/a-0631-4707
DO - 10.1055/a-0631-4707
M3 - Article
C2 - 30045399
SN - 1438-9010
VL - 190
SP - 747
EP - 757
JO - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
IS - 8
ER -