Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

Dominiek Smeets; Ian S. Miller; Darran P. O'Connor; Sudipto Das; Bruce Moran; Bram Boeckx; Timo Gaiser; Johannes Betge; Ana Barat; Rut Klinger; Nicole C. T. van Grieken; Chiara Cremolini; Hans Prenen; Massimiliano Mazzone; Jeroen Depreeuw; Orna Bacon; Bozena Fender; Joseph Brady; Bryan T. Hennessy; Deborah A. McNamara; Elaine Kay; Henk M. Verheul; Neerincx Maarten; William M. Gallagher; Verena Murphy; Jochen H. M. Prehn; Miriam Koopman; Cornelis J. A. Punt; Fotios Loupakis; Matthias P. A. Ebert; Bauke Ylstra; Diether Lambrechts; Annette T. Byrne

doi:10.1038/s41467-018-06567-6

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

Dominiek Smeets, Ian S. Miller, Darran P. O'Connor, Sudipto Das, Bruce Moran, Bram Boeckx, Timo Gaiser, Johannes Betge, Ana Barat, Rut Klinger, Nicole C. T. van Grieken, Chiara Cremolini, Hans Prenen, Massimiliano Mazzone, Jeroen Depreeuw, Orna Bacon, Bozena Fender, Joseph Brady, Bryan T. Hennessy, Deborah A. McNamaraElaine Kay, Henk M. Verheul, Neerincx Maarten, William M. Gallagher, Verena Murphy, Jochen H. M. Prehn, Miriam Koopman, Cornelis J. A. Punt, Fotios Loupakis, Matthias P. A. Ebert, Bauke Ylstra, Diether Lambrechts, Annette T. Byrne

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Journal	Nature Communications
Volume	9
DOIs	https://doi.org/10.1038/s41467-018-06567-6
Publication status	Published - 5 Oct 2018

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10.1038/s41467-018-06567-6

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Smeets, D., Miller, I. S., O'Connor, D. P., Das, S., Moran, B., Boeckx, B., Gaiser, T., Betge, J., Barat, A., Klinger, R., van Grieken, N. C. T., Cremolini, C., Prenen, H., Mazzone, M., Depreeuw, J., Bacon, O., Fender, B., Brady, J., Hennessy, B. T., ... Byrne, A. T. (2018). Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. Nature Communications, 9. https://doi.org/10.1038/s41467-018-06567-6

Smeets, Dominiek ; Miller, Ian S. ; O'Connor, Darran P. ; Das, Sudipto ; Moran, Bruce ; Boeckx, Bram ; Gaiser, Timo ; Betge, Johannes ; Barat, Ana ; Klinger, Rut ; van Grieken, Nicole C. T. ; Cremolini, Chiara ; Prenen, Hans ; Mazzone, Massimiliano ; Depreeuw, Jeroen ; Bacon, Orna ; Fender, Bozena ; Brady, Joseph ; Hennessy, Bryan T. ; McNamara, Deborah A. ; Kay, Elaine ; Verheul, Henk M. ; Maarten, Neerincx ; Gallagher, William M. ; Murphy, Verena ; Prehn, Jochen H. M. ; Koopman, Miriam ; Punt, Cornelis J. A. ; Loupakis, Fotios ; Ebert, Matthias P. A. ; Ylstra, Bauke ; Lambrechts, Diether ; Byrne, Annette T. / Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. In: Nature Communications. 2018 ; Vol. 9.

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title = "Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy",

author = "Dominiek Smeets and Miller, {Ian S.} and O'Connor, {Darran P.} and Sudipto Das and Bruce Moran and Bram Boeckx and Timo Gaiser and Johannes Betge and Ana Barat and Rut Klinger and {van Grieken}, {Nicole C. T.} and Chiara Cremolini and Hans Prenen and Massimiliano Mazzone and Jeroen Depreeuw and Orna Bacon and Bozena Fender and Joseph Brady and Hennessy, {Bryan T.} and McNamara, {Deborah A.} and Elaine Kay and Verheul, {Henk M.} and Neerincx Maarten and Gallagher, {William M.} and Verena Murphy and Prehn, {Jochen H. M.} and Miriam Koopman and Punt, {Cornelis J. A.} and Fotios Loupakis and Ebert, {Matthias P. A.} and Bauke Ylstra and Diether Lambrechts and Byrne, {Annette T.}",

year = "2018",

month = oct,

day = "5",

doi = "10.1038/s41467-018-06567-6",

language = "English",

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issn = "2041-1723",

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Smeets, D, Miller, IS, O'Connor, DP, Das, S, Moran, B, Boeckx, B, Gaiser, T, Betge, J, Barat, A, Klinger, R, van Grieken, NCT, Cremolini, C, Prenen, H, Mazzone, M, Depreeuw, J, Bacon, O, Fender, B, Brady, J, Hennessy, BT, McNamara, DA, Kay, E, Verheul, HM, Maarten, N, Gallagher, WM, Murphy, V, Prehn, JHM, Koopman, M, Punt, CJA, Loupakis, F, Ebert, MPA, Ylstra, B, Lambrechts, D & Byrne, AT 2018, 'Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy', Nature Communications, vol. 9. https://doi.org/10.1038/s41467-018-06567-6

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. / Smeets, Dominiek; Miller, Ian S.; O'Connor, Darran P.; Das, Sudipto; Moran, Bruce; Boeckx, Bram; Gaiser, Timo; Betge, Johannes; Barat, Ana; Klinger, Rut; van Grieken, Nicole C. T.; Cremolini, Chiara; Prenen, Hans; Mazzone, Massimiliano; Depreeuw, Jeroen; Bacon, Orna; Fender, Bozena; Brady, Joseph; Hennessy, Bryan T.; McNamara, Deborah A.; Kay, Elaine; Verheul, Henk M.; Maarten, Neerincx; Gallagher, William M.; Murphy, Verena; Prehn, Jochen H. M.; Koopman, Miriam; Punt, Cornelis J. A.; Loupakis, Fotios; Ebert, Matthias P. A.; Ylstra, Bauke; Lambrechts, Diether; Byrne, Annette T.

In: Nature Communications, Vol. 9, 05.10.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

AU - Smeets, Dominiek

AU - Miller, Ian S.

AU - O'Connor, Darran P.

AU - Das, Sudipto

AU - Moran, Bruce

AU - Boeckx, Bram

AU - Gaiser, Timo

AU - Betge, Johannes

AU - Barat, Ana

AU - Klinger, Rut

AU - van Grieken, Nicole C. T.

AU - Cremolini, Chiara

AU - Prenen, Hans

AU - Mazzone, Massimiliano

AU - Depreeuw, Jeroen

AU - Bacon, Orna

AU - Fender, Bozena

AU - Brady, Joseph

AU - Hennessy, Bryan T.

AU - McNamara, Deborah A.

AU - Kay, Elaine

AU - Verheul, Henk M.

AU - Maarten, Neerincx

AU - Gallagher, William M.

AU - Murphy, Verena

AU - Prehn, Jochen H. M.

AU - Koopman, Miriam

AU - Punt, Cornelis J. A.

AU - Loupakis, Fotios

AU - Ebert, Matthias P. A.

AU - Ylstra, Bauke

AU - Lambrechts, Diether

AU - Byrne, Annette T.

PY - 2018/10/5

Y1 - 2018/10/5

U2 - 10.1038/s41467-018-06567-6

DO - 10.1038/s41467-018-06567-6

M3 - Article

C2 - 30291241

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -