Coronary microcirculation in nonculprit vessel territory in reperfused acute myocardial infarction

Murat Sezer*, Ahmet Tas, Zeynep G. Demirtakan, Christopher J. Broyd, Alp Ozcan, Hakan Hasdemir, Mehmet Kocaaga, Irem Sezer, Mehmet R. Sonsoz, Adem Atici, Ilke Ozcan, Berrin Umman, Zehra Bugra, Justin E. Davies, Javier Escaned, N. van Royen, Sabahattin Umman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: There is an ongoing debate on the extension of reperfusion-related microvascular damage (MVD) throughout the remote noninfarcted myocardial regions in patients with ST-elevation myocardial infarction (STEMI) that undergo primary percutaneous intervention (pPCI). The aim of this study was to elucidate the impact of reperfusion on remote microcirculatory territory by analyzing hemodynamic alterations in the nonculprit-vessel in relation to reperfusion. Methods: A total of 20 patients with STEMI undergoing pPCI were included. Peri-reperfusion temporal changes in hemodynamic parameters were obtained in angiographically normal nonculprit vessels before and 1-h after reopening of the culprit vessel. Intracoronary pressure and flow velocity data were compared using pairwise analyses (before and 1-h after reperfusion). Results: In the non-culprit vessel, compared to the pre-reperfusion state, mean resting average peak velocity (33.4 ± 9.4 to 25.0 ± 4.9 cm/s, P < 0.001) and mean hyperemic average peak velocity (53.5 ± 14.4 to 42.1 ± 10.66 cm/s, P = 0.001) significantly decreased; whereas baseline (3.2 ± 1.0 to 4.0 ± 1.0 −1.s, P < 0.001) and hyperemic microvascular resistance (HMR) (1.9 ± 0.6 to 2.4 ± 0.7 −1.s, P < 0.001) and mean zero flow pressure (Pzf) values (32.5 ± 6.9 to 37.6 ± 8.3 mmHg, P = 0.003) significantly increased 1-h after reperfusion. In particular, the magnitude of changes in HMR and Pzf values following reperfusion were more prominent in patients with larger infarct size and with higher extent of MVD in the culprit vessel territory. Conclusion: Reperfusion-related microvascular injury extends to involve remote myocardial territory in relation to the magnitude of the adjacent infarction and infarct-zone MVD. (GUARD Clinical Trials NCT02732080).

Original languageEnglish
Article number104495
JournalMicrovascular Research
Publication statusPublished - 1 May 2023
Externally publishedYes

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