Correlation between tumor histology, steroid receptor status, and adenosine deaminase complexing protein immunoreactivity in ovarian cancer

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Abstract

Adenosine deaminase complexing protein (ADCP) immunoreactivity was investigated in 40 ovarian tumors and correlated with clinicopathologic parameters, including tumor steroid receptor content. Ten (29%) of 34 common epithelial ovarian carcinomas showed ADCP reactivity. Reactivity for ADCP was seen more frequently in mucinous (100%; p < 0.001), well-differentiated (73%; p < 0.001) and Stage I (56%; p < 0.05) ovarian carcinomas. Furthermore, tumors that contained high levels of androgen receptors and tumors that did not contain estrogen receptors were more frequently ADCP positive (p < 0.05). However, after stratifying for histologic grade, no correlation between ADCP reactivity and receptor status was found. Determination of ADCP reactivity appears to be of limited value in ovarian cancer.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalInternational Journal of Gynecological Pathology
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Jan 1990

Cite this

@article{bddd9539f43d476ab8080f61f7324ad9,
title = "Correlation between tumor histology, steroid receptor status, and adenosine deaminase complexing protein immunoreactivity in ovarian cancer",
abstract = "Adenosine deaminase complexing protein (ADCP) immunoreactivity was investigated in 40 ovarian tumors and correlated with clinicopathologic parameters, including tumor steroid receptor content. Ten (29{\%}) of 34 common epithelial ovarian carcinomas showed ADCP reactivity. Reactivity for ADCP was seen more frequently in mucinous (100{\%}; p < 0.001), well-differentiated (73{\%}; p < 0.001) and Stage I (56{\%}; p < 0.05) ovarian carcinomas. Furthermore, tumors that contained high levels of androgen receptors and tumors that did not contain estrogen receptors were more frequently ADCP positive (p < 0.05). However, after stratifying for histologic grade, no correlation between ADCP reactivity and receptor status was found. Determination of ADCP reactivity appears to be of limited value in ovarian cancer.",
keywords = "Histology, Ovarian tumors, Steroid receptors",
author = "Rao, {B. R.} and Slotman, {B. J.} and Geldof, {A. A.}",
year = "1990",
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doi = "10.1097/00004347-199001000-00004",
language = "English",
volume = "9",
pages = "47--54",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
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TY - JOUR

T1 - Correlation between tumor histology, steroid receptor status, and adenosine deaminase complexing protein immunoreactivity in ovarian cancer

AU - Rao, B. R.

AU - Slotman, B. J.

AU - Geldof, A. A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Adenosine deaminase complexing protein (ADCP) immunoreactivity was investigated in 40 ovarian tumors and correlated with clinicopathologic parameters, including tumor steroid receptor content. Ten (29%) of 34 common epithelial ovarian carcinomas showed ADCP reactivity. Reactivity for ADCP was seen more frequently in mucinous (100%; p < 0.001), well-differentiated (73%; p < 0.001) and Stage I (56%; p < 0.05) ovarian carcinomas. Furthermore, tumors that contained high levels of androgen receptors and tumors that did not contain estrogen receptors were more frequently ADCP positive (p < 0.05). However, after stratifying for histologic grade, no correlation between ADCP reactivity and receptor status was found. Determination of ADCP reactivity appears to be of limited value in ovarian cancer.

AB - Adenosine deaminase complexing protein (ADCP) immunoreactivity was investigated in 40 ovarian tumors and correlated with clinicopathologic parameters, including tumor steroid receptor content. Ten (29%) of 34 common epithelial ovarian carcinomas showed ADCP reactivity. Reactivity for ADCP was seen more frequently in mucinous (100%; p < 0.001), well-differentiated (73%; p < 0.001) and Stage I (56%; p < 0.05) ovarian carcinomas. Furthermore, tumors that contained high levels of androgen receptors and tumors that did not contain estrogen receptors were more frequently ADCP positive (p < 0.05). However, after stratifying for histologic grade, no correlation between ADCP reactivity and receptor status was found. Determination of ADCP reactivity appears to be of limited value in ovarian cancer.

KW - Histology

KW - Ovarian tumors

KW - Steroid receptors

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U2 - 10.1097/00004347-199001000-00004

DO - 10.1097/00004347-199001000-00004

M3 - Article

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JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

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