Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion

Doeschka A. Ferro, Henri J.J.M. Mutsaerts, Saima Hilal, Hugo J. Kuijf, Esben T. Petersen, Jan Petr, Susanne J. van Veluw, Narayanaswamy Venketasubramanian, Tan Boon Yeow, Geert Jan Biessels, Christopher Chen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 ± 9 years, 51% male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12% lower CBF (beta = −.20) and 22% higher spatial CoV (beta =.20) (both p <.05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia.

Original languageEnglish
JournalJournal of Cerebral Blood Flow and Metabolism
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Cite this

Ferro, Doeschka A. ; Mutsaerts, Henri J.J.M. ; Hilal, Saima ; Kuijf, Hugo J. ; Petersen, Esben T. ; Petr, Jan ; van Veluw, Susanne J. ; Venketasubramanian, Narayanaswamy ; Boon Yeow, Tan ; Jan Biessels, Geert ; Chen, Christopher. / Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion. In: Journal of Cerebral Blood Flow and Metabolism. 2019.
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abstract = "Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 ± 9 years, 51{\%} male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12{\%} lower CBF (beta = −.20) and 22{\%} higher spatial CoV (beta =.20) (both p <.05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia.",
keywords = "Arterial spin labeling, cerebral perfusion, dementia, microinfarct, vascular cognitive impairment",
author = "Ferro, {Doeschka A.} and Mutsaerts, {Henri J.J.M.} and Saima Hilal and Kuijf, {Hugo J.} and Petersen, {Esben T.} and Jan Petr and {van Veluw}, {Susanne J.} and Narayanaswamy Venketasubramanian and {Boon Yeow}, Tan and {Jan Biessels}, Geert and Christopher Chen",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/0271678X19877403",
language = "English",
journal = "Journal of Cerebral Blood Flow and Metabolism",
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Ferro, DA, Mutsaerts, HJJM, Hilal, S, Kuijf, HJ, Petersen, ET, Petr, J, van Veluw, SJ, Venketasubramanian, N, Boon Yeow, T, Jan Biessels, G & Chen, C 2019, 'Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion' Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X19877403

Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion. / Ferro, Doeschka A.; Mutsaerts, Henri J.J.M.; Hilal, Saima; Kuijf, Hugo J.; Petersen, Esben T.; Petr, Jan; van Veluw, Susanne J.; Venketasubramanian, Narayanaswamy; Boon Yeow, Tan; Jan Biessels, Geert; Chen, Christopher.

In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion

AU - Ferro, Doeschka A.

AU - Mutsaerts, Henri J.J.M.

AU - Hilal, Saima

AU - Kuijf, Hugo J.

AU - Petersen, Esben T.

AU - Petr, Jan

AU - van Veluw, Susanne J.

AU - Venketasubramanian, Narayanaswamy

AU - Boon Yeow, Tan

AU - Jan Biessels, Geert

AU - Chen, Christopher

PY - 2019/1/1

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N2 - Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 ± 9 years, 51% male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12% lower CBF (beta = −.20) and 22% higher spatial CoV (beta =.20) (both p <.05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia.

AB - Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 ± 9 years, 51% male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12% lower CBF (beta = −.20) and 22% higher spatial CoV (beta =.20) (both p <.05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia.

KW - Arterial spin labeling

KW - cerebral perfusion

KW - dementia

KW - microinfarct

KW - vascular cognitive impairment

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U2 - 10.1177/0271678X19877403

DO - 10.1177/0271678X19877403

M3 - Article

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

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