Abstract
Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = −0.111 to −0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.
Original language | English |
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Journal | Molecular Psychiatry |
Early online date | 2020 |
DOIs | |
Publication status | E-pub ahead of print - 2020 |
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Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. / Wang, Xin; Xie, Hong; Chen, Tian; Cotton, Andrew S.; Salminen, Lauren E.; Logue, Mark W.; Clarke-Rubright, Emily K.; Wall, John; Dennis, Emily L.; O’Leary, Brian M.; Abdallah, Chadi G.; Andrew, Elpiniki; Baugh, Lee A.; Bomyea, Jessica; Bruce, Steven E.; Bryant, Richard; Choi, Kyle; Daniels, Judith K.; Davenport, Nicholas D.; Davidson, Richard J.; DeBellis, Michael; deRoon-Cassini, Terri; Disner, Seth G.; Fani, Negar; Fercho, Kelene A.; Fitzgerald, Jacklynn; Forster, Gina L.; Frijling, Jessie L.; Geuze, Elbert; Gomaa, Hassaan; Gordon, Evan M.; Grupe, Dan; Harpaz-Rotem, Ilan; Haswell, Courtney C.; Herzog, Julia I.; Hofmann, David; Hollifield, Michael; Hosseini, Bobak; Hudson, Anna R.; Ipser, Jonathan; Jahanshad, Neda; Jovanovic, Tanja; Kaufman, Milissa L.; King, Anthony P.; Koch, Saskia B. J.; Koerte, Inga K.; Korgaonkar, Mayuresh S.; Krystal, John H.; Larson, Christine; Lebois, Lauren A. M.; Levy, Ifat; Li, Gen; Magnotta, Vincent A.; Manthey, Antje; May, Geoffrey; McLaughlin, Katie A.; Mueller, Sven C.; Nawijn, Laura; Nelson, Steven M.; Neria, Yuval; Nitschke, Jack B.; Olff, Miranda; Olson, Elizabeth A.; Peverill, Matthew; Luan Phan, K.; Rashid, Faisal M.; Ressler, Kerry; Rosso, Isabelle M.; Sambrook, Kelly; Schmahl, Christian; Shenton, Martha E.; Sierk, Anika; Simons, Jeffrey S.; Simons, Raluca M.; Sponheim, Scott R.; Stein, Murray B.; Stein, Dan J.; Stevens, Jennifer S.; Straube, Thomas; Suarez-Jimenez, Benjamin; Tamburrino, Marijo; Thomopoulos, Sophia I.; van der Wee, Nic J. A.; van der Werff, Steven J. A.; van Erp, Theo G. M.; van Rooij, Sanne J. H.; van Zuiden, Mirjam; Varkevisser, Tim; Veltman, Dick J.; Vermeiren, Robert R. J. M.; Walter, Henrik; Wang, Li; Zhu, Ye; Zhu, Xi; Thompson, Paul M.; Morey, Rajendra A.; Liberzon, Israel.
In: Molecular Psychiatry, 2020.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
AU - Wang, Xin
AU - Xie, Hong
AU - Chen, Tian
AU - Cotton, Andrew S.
AU - Salminen, Lauren E.
AU - Logue, Mark W.
AU - Clarke-Rubright, Emily K.
AU - Wall, John
AU - Dennis, Emily L.
AU - O’Leary, Brian M.
AU - Abdallah, Chadi G.
AU - Andrew, Elpiniki
AU - Baugh, Lee A.
AU - Bomyea, Jessica
AU - Bruce, Steven E.
AU - Bryant, Richard
AU - Choi, Kyle
AU - Daniels, Judith K.
AU - Davenport, Nicholas D.
AU - Davidson, Richard J.
AU - DeBellis, Michael
AU - deRoon-Cassini, Terri
AU - Disner, Seth G.
AU - Fani, Negar
AU - Fercho, Kelene A.
AU - Fitzgerald, Jacklynn
AU - Forster, Gina L.
AU - Frijling, Jessie L.
AU - Geuze, Elbert
AU - Gomaa, Hassaan
AU - Gordon, Evan M.
AU - Grupe, Dan
AU - Harpaz-Rotem, Ilan
AU - Haswell, Courtney C.
AU - Herzog, Julia I.
AU - Hofmann, David
AU - Hollifield, Michael
AU - Hosseini, Bobak
AU - Hudson, Anna R.
AU - Ipser, Jonathan
AU - Jahanshad, Neda
AU - Jovanovic, Tanja
AU - Kaufman, Milissa L.
AU - King, Anthony P.
AU - Koch, Saskia B. J.
AU - Koerte, Inga K.
AU - Korgaonkar, Mayuresh S.
AU - Krystal, John H.
AU - Larson, Christine
AU - Lebois, Lauren A. M.
AU - Levy, Ifat
AU - Li, Gen
AU - Magnotta, Vincent A.
AU - Manthey, Antje
AU - May, Geoffrey
AU - McLaughlin, Katie A.
AU - Mueller, Sven C.
AU - Nawijn, Laura
AU - Nelson, Steven M.
AU - Neria, Yuval
AU - Nitschke, Jack B.
AU - Olff, Miranda
AU - Olson, Elizabeth A.
AU - Peverill, Matthew
AU - Luan Phan, K.
AU - Rashid, Faisal M.
AU - Ressler, Kerry
AU - Rosso, Isabelle M.
AU - Sambrook, Kelly
AU - Schmahl, Christian
AU - Shenton, Martha E.
AU - Sierk, Anika
AU - Simons, Jeffrey S.
AU - Simons, Raluca M.
AU - Sponheim, Scott R.
AU - Stein, Murray B.
AU - Stein, Dan J.
AU - Stevens, Jennifer S.
AU - Straube, Thomas
AU - Suarez-Jimenez, Benjamin
AU - Tamburrino, Marijo
AU - Thomopoulos, Sophia I.
AU - van der Wee, Nic J. A.
AU - van der Werff, Steven J. A.
AU - van Erp, Theo G. M.
AU - van Rooij, Sanne J. H.
AU - van Zuiden, Mirjam
AU - Varkevisser, Tim
AU - Veltman, Dick J.
AU - Vermeiren, Robert R. J. M.
AU - Walter, Henrik
AU - Wang, Li
AU - Zhu, Ye
AU - Zhu, Xi
AU - Thompson, Paul M.
AU - Morey, Rajendra A.
AU - Liberzon, Israel
PY - 2020
Y1 - 2020
N2 - Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = −0.111 to −0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.
AB - Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = −0.111 to −0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097223053&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33288872
UR - http://www.scopus.com/inward/record.url?scp=85097223053&partnerID=8YFLogxK
U2 - 10.1038/s41380-020-00967-1
DO - 10.1038/s41380-020-00967-1
M3 - Article
C2 - 33288872
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
ER -