COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions

Shari B. Brosnahan, Annemijn H. Jonkman, Matthias C. Kugler, John S. Munger, David A. Kaufman

Research output: Contribution to journalReview articleAcademicpeer-review


The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.
Original languageEnglish
Pages (from-to)2586-2597
Number of pages12
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number11
Publication statusPublished - 1 Nov 2020

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