Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2094-2105 |
| Number of pages | 12 |
| Journal | Nephrology, Dialysis, Transplantation |
| Volume | 36 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1 Nov 2021 |
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COVID-19-related mortality in kidney transplant and haemodialysis patients : A comparative, prospective registry-based study. / Goffin, Eric; Candellier, Alexandre; Vart, Priya et al.
In: Nephrology, Dialysis, Transplantation, Vol. 36, No. 11, 01.11.2021, p. 2094-2105.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - COVID-19-related mortality in kidney transplant and haemodialysis patients
T2 - A comparative, prospective registry-based study
AU - Goffin, Eric
AU - Candellier, Alexandre
AU - Vart, Priya
AU - Noordzij, Marlies
AU - Arnol, Miha
AU - Covic, Adrian
AU - Lentini, Paolo
AU - Malik, Shafi
AU - Reichert, Louis J.
AU - Sever, Mehmet S.
AU - Watschinger, Bruno
AU - Jager, Kitty J.
AU - Gansevoort, Ron T.
AU - ERACODA Collaborators
AU - van der Net, Jeroen B.
AU - Essig, Marie
AU - du Buf-Vereijken, Peggy W. G.
AU - van Ginneken, Betty
AU - Vogt, Liffert
AU - van Jaarsveld, Brigit C.
AU - Bemelman, Frederike J.
AU - Klingenberg-Salahova, Farah
AU - Heenan-Vos, Frederiek
AU - Vervloet, Marc G.
AU - Nurmohamed, Azam
AU - Abramowicz, Daniel
AU - Verhofstede, Sabine
AU - Maoujoud, Omar
AU - Malfait, Thomas
AU - Avitum, B. Braun
AU - Fialova, Jana
AU - Melilli, Edoardo
AU - Favà, Alexandre
AU - Cruzado, Josep M.
AU - Perez, Nuria Montero
AU - Lips, Joy
AU - Krepel, Harmen
AU - Adilovic, Harun
AU - Hengst, Maaike
AU - Rydzewski, Andrzej
AU - Gellert, Ryszard
AU - Oliveira, João
AU - Alferes, Daniela G.
AU - Zakharova, Elena V.
AU - Ambuehl, Patrice Max
AU - Walker, Andrea
AU - Winzeler, Rebecca
AU - Lepeytre, Fanny
AU - Rabaté, Clémentine
AU - Rostoker, Guy
AU - Marques, Sofia
AU - Azasevac, Tijana
AU - Katicic, Dajana
AU - ten Dam, Marc
AU - Krüger, Thilo
AU - Brzosko, Szymon
AU - Zanen, Adriaan L.
AU - Logtenberg, Susan J. J.
AU - Fricke, Lutz
AU - Slebe, Jeroen J. P.
AU - Kemlin, Delphine
AU - van de Wetering, Jacqueline
AU - Reinders, Marlies E. J.
AU - Eiselt, Jaromir
AU - Kielberger, Lukas
AU - el-Wakil, Hala S.
AU - Verhoeven, Martine A. M.
AU - Canal, Cristina
AU - Facundo, Carme
AU - Ramos, Ana M.
AU - Debska-Slizien, Alicja
AU - Veldhuizen, Nicoline M. H.
AU - Tigka, Eirini
AU - Konsta, Maria Anna Polyzou
AU - Panagoutsos, Stylianos
AU - Mallamaci, Francesca
AU - Matceac, Irina
AU - Nistor, Ionut
AU - Cordos, Monica
AU - Groeneveld, J. H. M.
AU - Jousma, Jolanda
AU - van Buren, Marjolijn
AU - Elhafeez, Samar Abd
AU - Diekmann, Fritz
AU - Pereira, Tiago Assis
AU - Santos, Augusto Cesar S.
AU - Arias-Cabrales, Carlos
AU - Crespo, Marta
AU - Llinàs-Mallol, Laura
AU - Buxeda, Anna
AU - Tàrrega, Carla Burballa
AU - Redondo-Pachon, Dolores
AU - Jimenez, Maria Dolores Arenas
AU - Hofstra, Julia M.
AU - Franco, Antonio
AU - Arroyo, David
AU - Rodríguez-Ferrero, Maria Luisa
AU - Manzanos, Sagrario Balda
AU - Barrios, R. Haridian Sosa
AU - Ávila, Gonçalo
AU - Laranjinha, Ivo
AU - Mateus, Catarina
AU - Lemahieu, Wim
AU - Dirim, Ahmet Burak
AU - Demir, Erol
AU - Å afak, Seda
AU - Turkmen, Aydin
AU - Hollander, Daan A. M. J.
AU - Büttner, Stefan
AU - de Vries, Aiko P. J.
AU - Meziyerh, Soufian
AU - van der Helm, Danny
AU - Mallat, Marko
AU - Bouwsma, Hanneke
AU - Sridharan, Sivakumar
AU - Petruliene, Kristina
AU - Maloney, Sharon-Rose
AU - Verberk, Iris
AU - van der Sande, Frank M.
AU - Christiaans, Maarten H. L.
AU - Hemmelder, Marc
AU - Kumar, Mohan N.
AU - di Luca, Marina
AU - Tuǧlular, Serhan Z.
AU - Kramer, Andrea
AU - Beerenhout, Charles
AU - Luik, Peter T.
AU - Kerschbaum, Julia
AU - Tiefenthaler, Martin
AU - Adema, Aaltje Y.
AU - Stepanov, Vadim A.
AU - Zulkarnaev, Alexey B.
AU - Turkmen, Kultigin
AU - Fliedner, Anselm
AU - Åsberg, Anders
AU - Mjoen, Geir
AU - Miyasato, Hitoshi
AU - de Fijter, Carola W. H.
AU - Mongera, Nicola
AU - Pini, Stefano
AU - de Biase, Consuelo
AU - Duivenvoorden, Raphaël
AU - Hilbrands, Luuk
AU - Kerckhoffs, Angele
AU - Maas, Rutger
AU - Lebedeva, Olga
AU - Lopez, Veronica
AU - Verhave, Jacobien
AU - Titov, Denis
AU - Parshina, Ekaterina V.
AU - Zanoli, Luca
AU - Marcantoni, Carmelita
AU - van Gils-Verrij, Liesbeth E. A.
AU - Harty, John C.
AU - Meurs, Marleen
AU - Myslak, Marek
AU - Battaglia, Yuri
AU - den Deurwaarder, Edwin
AU - Stendahl, Maria
AU - Rahimzadeh, Hormat
AU - Schouten, Marcel
AU - Rychlik, Ivan
AU - Cabezas-Reina, Carlos J.
AU - Roca, Ana Maria
AU - Nauta, Ferdau
AU - Kanaan, Nada
AU - Labriola, Laura
AU - Devresse, Arnaud
AU - Diaz-Mareque, Anabel
AU - Coca, Armando
AU - Meijers, Björn K. I.
AU - Naesens, Maarten
AU - Kuypers, Dirk
AU - Desschans, Bruno
AU - Tonnelier, Annelies
AU - Wissing, Karl M.
AU - de Arriba, Gabriel
AU - Dedinska, Ivana
AU - Pessolano, Giuseppina
AU - Gandolfini, Ilaria
AU - Maggiore, Umberto
AU - Papachristou, Evangelos
AU - Franssen, Casper F. M.
AU - Berger, Stefan P.
AU - Meijer, Esther
AU - Özyilmaz, Akin
AU - Sanders, Jan Stephan F.
AU - Ponikvar, Jadranka Buturović
AU - Pernat, Andreja Marn
AU - Kovac, Damjan
AU - Ekart, Robert
AU - Abrahams, Alferso C.
AU - Molenaar, Femke M.
AU - van Zuilen, Arjan D.
AU - Meijvis, Sabine C. A.
AU - Dolmans, Helma
AU - Tantisattamos, Ekamol
AU - Esposito, Pasquale
AU - Krzesinski, Jean-Marie
AU - Barahira, Jean Damacène
AU - Gallieni, Maurizio
AU - Sabiu, Gianmarco
AU - Martin-Moreno, Paloma Leticia
AU - Guglielmetti, Gabriele
AU - Guzzo, Gabriella
AU - Toapanta, Nestor
AU - Luik, Antinus J.
AU - van Kuijk, Willi H. M.
AU - Stikkelbroeck, Lonneke W. H.
AU - Hermans, Marc M. H.
AU - Rimsevicius, Laurynas
AU - Righetti, Marco
AU - Islam, Mahmud
AU - Braak, Nicole Heitink-Ter
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Background: Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the association of the type of KRT with COVID-19 severity, adjusting for differences in individual characteristics. Methods: Data on KT recipients and HD patients diagnosed with COVID-19 between 1 February 2020 and 1 December 2020 were retrieved from the European Renal Association COVID-19 Database. Cox regression models adjusted for age, sex, frailty and comorbidities were used to estimate hazard ratios (HRs) for 28-day mortality risk in all patients and in the subsets that were tested because of symptoms. Results: A total of 1670 patients (496 functional KT and 1174 HD) were included; 16.9% of KT and 23.9% of HD patients died within 28 days of presentation. The unadjusted 28-day mortality risk was 33% lower in KT recipients compared with HD patients {HR 0.67 [95% confidence interval (CI) 0.52-0.85]}. In a fully adjusted model, the risk was 78% higher in KT recipients [HR 1.78 (95% CI 1.22-2.61)] compared with HD patients. This association was similar in patients tested because of symptoms [fully adjusted model HR 2.00 (95% CI 1.31-3.06)]. This risk was dramatically increased during the first post-transplant year. Results were similar for other endpoints (e.g. hospitalization, intensive care unit admission and mortality >28 days) and across subgroups. Conclusions: KT recipients had a greater risk of a more severe course of COVID-19 compared with HD patients, therefore they require specific infection mitigation strategies.
AB - Background: Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the association of the type of KRT with COVID-19 severity, adjusting for differences in individual characteristics. Methods: Data on KT recipients and HD patients diagnosed with COVID-19 between 1 February 2020 and 1 December 2020 were retrieved from the European Renal Association COVID-19 Database. Cox regression models adjusted for age, sex, frailty and comorbidities were used to estimate hazard ratios (HRs) for 28-day mortality risk in all patients and in the subsets that were tested because of symptoms. Results: A total of 1670 patients (496 functional KT and 1174 HD) were included; 16.9% of KT and 23.9% of HD patients died within 28 days of presentation. The unadjusted 28-day mortality risk was 33% lower in KT recipients compared with HD patients {HR 0.67 [95% confidence interval (CI) 0.52-0.85]}. In a fully adjusted model, the risk was 78% higher in KT recipients [HR 1.78 (95% CI 1.22-2.61)] compared with HD patients. This association was similar in patients tested because of symptoms [fully adjusted model HR 2.00 (95% CI 1.31-3.06)]. This risk was dramatically increased during the first post-transplant year. Results were similar for other endpoints (e.g. hospitalization, intensive care unit admission and mortality >28 days) and across subgroups. Conclusions: KT recipients had a greater risk of a more severe course of COVID-19 compared with HD patients, therefore they require specific infection mitigation strategies.
KW - COVID-19
KW - Humans
KW - Kidney Failure, Chronic/therapy
KW - Kidney Transplantation/adverse effects
KW - Registries
KW - Renal Dialysis
KW - Risk Factors
KW - SARS-CoV-2
KW - Transplant Recipients
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85115119903&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34132811
U2 - 10.1093/ndt/gfab200
DO - 10.1093/ndt/gfab200
M3 - Article
C2 - 34132811
SN - 0931-0509
VL - 36
SP - 2094
EP - 2105
JO - Nephrology, Dialysis, Transplantation
JF - Nephrology, Dialysis, Transplantation
IS - 11
ER -