Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology

Peter de Boer; Maaike C G Bleeker; Anje M Spijkerboer; Agustinus J A J van de Schoot; Shandra Bipat; Marrije R Buist; Coen R N Rasch; Jaap Stoker; Lukas J A Stalpers

doi:10.1016/j.ejro.2015.07.001

Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology

Peter de Boer, Maaike C G Bleeker, Anje M Spijkerboer, Agustinus J A J van de Schoot, Shandra Bipat, Marrije R Buist, Coen R N Rasch, Jaap Stoker, Lukas J A Stalpers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.

MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.

RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.

CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

Original language	English
Pages (from-to)	111-7
Number of pages	7
Journal	European Journal of Radiology Open
Volume	2
DOIs	https://doi.org/10.1016/j.ejro.2015.07.001
Publication status	Published - 2015

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10.1016/j.ejro.2015.07.001

Cite this

@article{f210ebe95f844e47b251d5dc44b29ea4,

title = "Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology",

abstract = "PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.",

keywords = "Journal Article",

author = "{de Boer}, Peter and Bleeker, {Maaike C G} and Spijkerboer, {Anje M} and {van de Schoot}, {Agustinus J A J} and Shandra Bipat and Buist, {Marrije R} and Rasch, {Coen R N} and Jaap Stoker and Stalpers, {Lukas J A}",

year = "2015",

doi = "10.1016/j.ejro.2015.07.001",

language = "English",

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pages = "111--7",

journal = "European Journal of Radiology Open",

issn = "2352-0477",

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T1 - Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology

AU - de Boer, Peter

AU - Bleeker, Maaike C G

AU - Spijkerboer, Anje M

AU - van de Schoot, Agustinus J A J

AU - Bipat, Shandra

AU - Buist, Marrije R

AU - Rasch, Coen R N

AU - Stoker, Jaap

AU - Stalpers, Lukas J A

PY - 2015

Y1 - 2015

N2 - PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

AB - PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

KW - Journal Article

U2 - 10.1016/j.ejro.2015.07.001

DO - 10.1016/j.ejro.2015.07.001

M3 - Article

C2 - 26937443

VL - 2

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JO - European Journal of Radiology Open

JF - European Journal of Radiology Open

SN - 2352-0477

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