Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology

Peter de Boer, Maaike C G Bleeker, Anje M Spijkerboer, Agustinus J A J van de Schoot, Shandra Bipat, Marrije R Buist, Coen R N Rasch, Jaap Stoker, Lukas J A Stalpers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.

MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.

RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.

CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

Original languageEnglish
Pages (from-to)111-7
Number of pages7
JournalEuropean Journal of Radiology Open
Volume2
DOIs
Publication statusPublished - 2015

Cite this

de Boer, P., Bleeker, M. C. G., Spijkerboer, A. M., van de Schoot, A. J. A. J., Bipat, S., Buist, M. R., ... Stalpers, L. J. A. (2015). Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology. European Journal of Radiology Open, 2, 111-7. https://doi.org/10.1016/j.ejro.2015.07.001
de Boer, Peter ; Bleeker, Maaike C G ; Spijkerboer, Anje M ; van de Schoot, Agustinus J A J ; Bipat, Shandra ; Buist, Marrije R ; Rasch, Coen R N ; Stoker, Jaap ; Stalpers, Lukas J A. / Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology. In: European Journal of Radiology Open. 2015 ; Vol. 2. pp. 111-7.
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abstract = "PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9{\%}) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.",
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de Boer, P, Bleeker, MCG, Spijkerboer, AM, van de Schoot, AJAJ, Bipat, S, Buist, MR, Rasch, CRN, Stoker, J & Stalpers, LJA 2015, 'Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology' European Journal of Radiology Open, vol. 2, pp. 111-7. https://doi.org/10.1016/j.ejro.2015.07.001

Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology. / de Boer, Peter; Bleeker, Maaike C G; Spijkerboer, Anje M; van de Schoot, Agustinus J A J; Bipat, Shandra; Buist, Marrije R; Rasch, Coen R N; Stoker, Jaap; Stalpers, Lukas J A.

In: European Journal of Radiology Open, Vol. 2, 2015, p. 111-7.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology

AU - de Boer, Peter

AU - Bleeker, Maaike C G

AU - Spijkerboer, Anje M

AU - van de Schoot, Agustinus J A J

AU - Bipat, Shandra

AU - Buist, Marrije R

AU - Rasch, Coen R N

AU - Stoker, Jaap

AU - Stalpers, Lukas J A

PY - 2015

Y1 - 2015

N2 - PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

AB - PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

KW - Journal Article

U2 - 10.1016/j.ejro.2015.07.001

DO - 10.1016/j.ejro.2015.07.001

M3 - Article

VL - 2

SP - 111

EP - 117

JO - European Journal of Radiology Open

JF - European Journal of Radiology Open

SN - 2352-0477

ER -