Craniocaudal tumour extension in uterine cervical cancer on MRI compared to histopathology

Peter de Boer, Maaike C G Bleeker, Anje M Spijkerboer, Agustinus J A J van de Schoot, Shandra Bipat, Marrije R Buist, Coen R N Rasch, Jaap Stoker, Lukas J A Stalpers

Research output: Contribution to journalArticleAcademicpeer-review


PURPOSE: To assess the reliability of magnetic resonance imaging (MRI) for evaluation of craniocaudal tumour extension by comparing the craniocaudal tumour extension on the pre-operative MRI and post-operative hysterectomy specimen in patients with early stage uterine cervical cancer.

MATERIALS AND METHODS: After approval of the institutional review board was acquired, pre-operative MRI and hysterectomy specimen of 21 women with early stage cervical cancer were re-evaluated. The craniocaudal extension on MRI was measured separately by two experienced radiologists and compared with corresponding measurements from the hysterectomy specimen, which were re-evaluated by an experienced pathologist.

RESULTS: Median craniocaudal extension of uterine cervical cancer on MRI was slightly smaller compared to histopathology (2.1 cm vs. 2.5 cm). The median underestimation was 0.4 cm (range -0.6 cm to 2.2 cm, mean 0.4 cm, standard deviation (SD) ±0.7 cm); Pearson's correlation was 0.83 (p < 0.001). In two patients (9%) MRI underestimated tumour craniocaudal extension by more than 1.8 cm.

CONCLUSION: MRI represents the histopathological craniocaudal tumour extension in the majority of patients with early stage uterine cervical cancer, but with a systematic small underestimation of the real craniocaudal tumour extension.

Original languageEnglish
Pages (from-to)111-7
Number of pages7
JournalEuropean Journal of Radiology Open
Publication statusPublished - 2015

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