Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 118-122 |
| Journal | Pregnancy Hypertension |
| Volume | 15 |
| DOIs | |
| Publication status | Published - 2019 |
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Creatine kinase and blood pressure in women with a history of early-onset preeclampsia. / Horjus, Deborah L.; Bokslag, Anouk; Hooijberg, Femke; Hutten, Barbara A.; Middeldorp, Saskia; de Groot, Christianne J. M.
In: Pregnancy Hypertension, Vol. 15, 2019, p. 118-122.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Creatine kinase and blood pressure in women with a history of early-onset preeclampsia
AU - Horjus, Deborah L.
AU - Bokslag, Anouk
AU - Hooijberg, Femke
AU - Hutten, Barbara A.
AU - Middeldorp, Saskia
AU - de Groot, Christianne J. M.
PY - 2019
Y1 - 2019
N2 - Objectives: High plasma creatine kinase (CK) activity is associated with hypertension in the general and pregnant population. We hypothesize that women with a history of early-onset preeclampsia are prone to hypertension due to a high CK activity level. Study design: Nine to 16 years after pregnancy, serum CK activity and blood pressure were measured in 117 women with a history of early-onset preeclampsia and 50 women with a history of an uncomplicated pregnancy. Main outcome measures: CK activity levels of the two groups were compared using the Mann-Whitney U test. The association between CK activity and blood pressure was evaluated by means of multivariable regression analysis. Results: There was no significant difference in median (interquartile range) CK activity between women with a history of early-onset preeclampsia and an uncomplicated pregnancy (59.00 [47.00–85.00] vs. 58.00 [46.50–75.25], respectively, p = 0.774). The association between CK and systolic blood pressure was significant in women with a pregnancy history of early-onset preeclampsia (regression coefficient [95% confidence interval]: 0.123 mmHg [0.020–0.226], p = 0.019), and a trend was found for diastolic blood pressure (p = 0.069). CK and blood pressure were not significantly associated in women with a history of an uncomplicated pregnancy. Conclusions: Median CK did not significantly differ between the two groups. Serum CK activity was significantly associated with systolic blood pressure in women with a history of early-onset preeclampsia. These data suggest that CK is not a predominant factor in the increased risk of hypertension in women with a history of early-onset preeclampsia.
AB - Objectives: High plasma creatine kinase (CK) activity is associated with hypertension in the general and pregnant population. We hypothesize that women with a history of early-onset preeclampsia are prone to hypertension due to a high CK activity level. Study design: Nine to 16 years after pregnancy, serum CK activity and blood pressure were measured in 117 women with a history of early-onset preeclampsia and 50 women with a history of an uncomplicated pregnancy. Main outcome measures: CK activity levels of the two groups were compared using the Mann-Whitney U test. The association between CK activity and blood pressure was evaluated by means of multivariable regression analysis. Results: There was no significant difference in median (interquartile range) CK activity between women with a history of early-onset preeclampsia and an uncomplicated pregnancy (59.00 [47.00–85.00] vs. 58.00 [46.50–75.25], respectively, p = 0.774). The association between CK and systolic blood pressure was significant in women with a pregnancy history of early-onset preeclampsia (regression coefficient [95% confidence interval]: 0.123 mmHg [0.020–0.226], p = 0.019), and a trend was found for diastolic blood pressure (p = 0.069). CK and blood pressure were not significantly associated in women with a history of an uncomplicated pregnancy. Conclusions: Median CK did not significantly differ between the two groups. Serum CK activity was significantly associated with systolic blood pressure in women with a history of early-onset preeclampsia. These data suggest that CK is not a predominant factor in the increased risk of hypertension in women with a history of early-onset preeclampsia.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059518603&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30825907
U2 - 10.1016/j.preghy.2018.12.009
DO - 10.1016/j.preghy.2018.12.009
M3 - Article
VL - 15
SP - 118
EP - 122
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
SN - 2210-7789
ER -