Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution

Luuk Voskuilen, Valentina Mazzoli, Jos Oudeman, Alfons J. M. Balm, Ferdinand van der Heijden, Martijn Froeling, Maartje M. L. de Win, Gustav J. Strijkers, Ludi E. Smeele, Aart J. Nederveen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Surgical resection of tongue cancer may impair swallowing and speech. Knowledge of tongue muscle architecture affected by the resection could aid in patient counseling. Diffusion tensor imaging (DTI) enables reconstructions of muscle architecture in vivo. Reconstructing crossing fibers in the tongue requires a higher-order diffusion model. Purpose: To develop a clinically feasible diffusion imaging protocol, which facilitates both DTI and constrained spherical deconvolution (CSD) reconstructions of tongue muscle architecture in vivo. Study Type: Cross-sectional study. Subjects/Specimen: One ex vivo bovine tongue resected en bloc from mandible to hyoid bone. Ten healthy volunteers (mean age 25.5 years; range 21–34 years; four female). Field Strength/Sequence: Diffusion-weighted echo planar imaging at 3 T using a high-angular resolution diffusion imaging scheme acquired twice with opposing phase-encoding for B0-field inhomogeneity correction. The scan of the healthy volunteers was divided into four parts, in between which the volunteers were allowed to swallow, resulting in a total acquisition time of 10 minutes. Assessment: The ability of resolving crossing muscle fibers using CSD was determined on the bovine tongue specimen. A reproducible response function was estimated and the optimal peak threshold was determined for the in vivo tongue. The quality of tractography of the in vivo tongue was graded by three experts. Statistical Tests: The within-subject coefficient of variance was calculated for the response function. The qualitative results of the grading of DTI and CSD tractography were analyzed using a multilevel proportional odds model. Results: Fiber orientation distributions in the bovine tongue specimen showed that CSD was able to resolve crossing muscle fibers. The response function could be determined reproducibly in vivo. CSD tractography displayed significantly improved tractography compared with DTI tractography (P = 0.015). Data Conclusion: The 10-minute diffusion imaging protocol facilitates CSD fiber tracking with improved reconstructions of crossing tongue muscle fibers compared with DTI. Level of Evidence: 2. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2019;50:96–105.
Original languageEnglish
Pages (from-to)96-105
JournalJournal of Magnetic Resonance Imaging
Volume50
Issue number1
DOIs
Publication statusPublished - 2019

Cite this

Voskuilen, L., Mazzoli, V., Oudeman, J., Balm, A. J. M., van der Heijden, F., Froeling, M., ... Nederveen, A. J. (2019). Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution. Journal of Magnetic Resonance Imaging, 50(1), 96-105. https://doi.org/10.1002/jmri.26609
Voskuilen, Luuk ; Mazzoli, Valentina ; Oudeman, Jos ; Balm, Alfons J. M. ; van der Heijden, Ferdinand ; Froeling, Martijn ; de Win, Maartje M. L. ; Strijkers, Gustav J. ; Smeele, Ludi E. ; Nederveen, Aart J. / Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution. In: Journal of Magnetic Resonance Imaging. 2019 ; Vol. 50, No. 1. pp. 96-105.
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title = "Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution",
abstract = "Background: Surgical resection of tongue cancer may impair swallowing and speech. Knowledge of tongue muscle architecture affected by the resection could aid in patient counseling. Diffusion tensor imaging (DTI) enables reconstructions of muscle architecture in vivo. Reconstructing crossing fibers in the tongue requires a higher-order diffusion model. Purpose: To develop a clinically feasible diffusion imaging protocol, which facilitates both DTI and constrained spherical deconvolution (CSD) reconstructions of tongue muscle architecture in vivo. Study Type: Cross-sectional study. Subjects/Specimen: One ex vivo bovine tongue resected en bloc from mandible to hyoid bone. Ten healthy volunteers (mean age 25.5 years; range 21–34 years; four female). Field Strength/Sequence: Diffusion-weighted echo planar imaging at 3 T using a high-angular resolution diffusion imaging scheme acquired twice with opposing phase-encoding for B0-field inhomogeneity correction. The scan of the healthy volunteers was divided into four parts, in between which the volunteers were allowed to swallow, resulting in a total acquisition time of 10 minutes. Assessment: The ability of resolving crossing muscle fibers using CSD was determined on the bovine tongue specimen. A reproducible response function was estimated and the optimal peak threshold was determined for the in vivo tongue. The quality of tractography of the in vivo tongue was graded by three experts. Statistical Tests: The within-subject coefficient of variance was calculated for the response function. The qualitative results of the grading of DTI and CSD tractography were analyzed using a multilevel proportional odds model. Results: Fiber orientation distributions in the bovine tongue specimen showed that CSD was able to resolve crossing muscle fibers. The response function could be determined reproducibly in vivo. CSD tractography displayed significantly improved tractography compared with DTI tractography (P = 0.015). Data Conclusion: The 10-minute diffusion imaging protocol facilitates CSD fiber tracking with improved reconstructions of crossing tongue muscle fibers compared with DTI. Level of Evidence: 2. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2019;50:96–105.",
author = "Luuk Voskuilen and Valentina Mazzoli and Jos Oudeman and Balm, {Alfons J. M.} and {van der Heijden}, Ferdinand and Martijn Froeling and {de Win}, {Maartje M. L.} and Strijkers, {Gustav J.} and Smeele, {Ludi E.} and Nederveen, {Aart J.}",
year = "2019",
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Voskuilen, L, Mazzoli, V, Oudeman, J, Balm, AJM, van der Heijden, F, Froeling, M, de Win, MML, Strijkers, GJ, Smeele, LE & Nederveen, AJ 2019, 'Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution' Journal of Magnetic Resonance Imaging, vol. 50, no. 1, pp. 96-105. https://doi.org/10.1002/jmri.26609

Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution. / Voskuilen, Luuk; Mazzoli, Valentina; Oudeman, Jos; Balm, Alfons J. M.; van der Heijden, Ferdinand; Froeling, Martijn; de Win, Maartje M. L.; Strijkers, Gustav J.; Smeele, Ludi E.; Nederveen, Aart J.

In: Journal of Magnetic Resonance Imaging, Vol. 50, No. 1, 2019, p. 96-105.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Crossing muscle fibers of the human tongue resolved in vivo using constrained spherical deconvolution

AU - Voskuilen, Luuk

AU - Mazzoli, Valentina

AU - Oudeman, Jos

AU - Balm, Alfons J. M.

AU - van der Heijden, Ferdinand

AU - Froeling, Martijn

AU - de Win, Maartje M. L.

AU - Strijkers, Gustav J.

AU - Smeele, Ludi E.

AU - Nederveen, Aart J.

PY - 2019

Y1 - 2019

N2 - Background: Surgical resection of tongue cancer may impair swallowing and speech. Knowledge of tongue muscle architecture affected by the resection could aid in patient counseling. Diffusion tensor imaging (DTI) enables reconstructions of muscle architecture in vivo. Reconstructing crossing fibers in the tongue requires a higher-order diffusion model. Purpose: To develop a clinically feasible diffusion imaging protocol, which facilitates both DTI and constrained spherical deconvolution (CSD) reconstructions of tongue muscle architecture in vivo. Study Type: Cross-sectional study. Subjects/Specimen: One ex vivo bovine tongue resected en bloc from mandible to hyoid bone. Ten healthy volunteers (mean age 25.5 years; range 21–34 years; four female). Field Strength/Sequence: Diffusion-weighted echo planar imaging at 3 T using a high-angular resolution diffusion imaging scheme acquired twice with opposing phase-encoding for B0-field inhomogeneity correction. The scan of the healthy volunteers was divided into four parts, in between which the volunteers were allowed to swallow, resulting in a total acquisition time of 10 minutes. Assessment: The ability of resolving crossing muscle fibers using CSD was determined on the bovine tongue specimen. A reproducible response function was estimated and the optimal peak threshold was determined for the in vivo tongue. The quality of tractography of the in vivo tongue was graded by three experts. Statistical Tests: The within-subject coefficient of variance was calculated for the response function. The qualitative results of the grading of DTI and CSD tractography were analyzed using a multilevel proportional odds model. Results: Fiber orientation distributions in the bovine tongue specimen showed that CSD was able to resolve crossing muscle fibers. The response function could be determined reproducibly in vivo. CSD tractography displayed significantly improved tractography compared with DTI tractography (P = 0.015). Data Conclusion: The 10-minute diffusion imaging protocol facilitates CSD fiber tracking with improved reconstructions of crossing tongue muscle fibers compared with DTI. Level of Evidence: 2. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2019;50:96–105.

AB - Background: Surgical resection of tongue cancer may impair swallowing and speech. Knowledge of tongue muscle architecture affected by the resection could aid in patient counseling. Diffusion tensor imaging (DTI) enables reconstructions of muscle architecture in vivo. Reconstructing crossing fibers in the tongue requires a higher-order diffusion model. Purpose: To develop a clinically feasible diffusion imaging protocol, which facilitates both DTI and constrained spherical deconvolution (CSD) reconstructions of tongue muscle architecture in vivo. Study Type: Cross-sectional study. Subjects/Specimen: One ex vivo bovine tongue resected en bloc from mandible to hyoid bone. Ten healthy volunteers (mean age 25.5 years; range 21–34 years; four female). Field Strength/Sequence: Diffusion-weighted echo planar imaging at 3 T using a high-angular resolution diffusion imaging scheme acquired twice with opposing phase-encoding for B0-field inhomogeneity correction. The scan of the healthy volunteers was divided into four parts, in between which the volunteers were allowed to swallow, resulting in a total acquisition time of 10 minutes. Assessment: The ability of resolving crossing muscle fibers using CSD was determined on the bovine tongue specimen. A reproducible response function was estimated and the optimal peak threshold was determined for the in vivo tongue. The quality of tractography of the in vivo tongue was graded by three experts. Statistical Tests: The within-subject coefficient of variance was calculated for the response function. The qualitative results of the grading of DTI and CSD tractography were analyzed using a multilevel proportional odds model. Results: Fiber orientation distributions in the bovine tongue specimen showed that CSD was able to resolve crossing muscle fibers. The response function could be determined reproducibly in vivo. CSD tractography displayed significantly improved tractography compared with DTI tractography (P = 0.015). Data Conclusion: The 10-minute diffusion imaging protocol facilitates CSD fiber tracking with improved reconstructions of crossing tongue muscle fibers compared with DTI. Level of Evidence: 2. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2019;50:96–105.

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