CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats

Petra J G Zwijnenburg, Machteld M J Polfliet, Sandrine Florquin, Timo K van den Berg, Christine D Dijkstra, Sander J H van Deventer, John J Roord, Tom van der Poll, A Marceline van Furth

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Intracisternal injection of the CXC-chemokines KC or macrophage inflammatory protein (MIP)-2 induced a pleocytosis in the cerebrospinal fluid (CSF) of rats in a dose dependent way. MIP-2 was much more potent than KC. The concurrent injection of both chemokines revealed a profound synergistic effect on leukocyte recruitment into CSF.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalImmunology Letters
Issue number1
Publication statusPublished - 2 Jan 2003

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