Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Erik Asmus; Weronika Karle; Markus C. Brack; Corey Wittig; Felix Behrens; Leander Reinshagen; Moritz Pfeiffer; Sabrina Schulz; Bertina Mandzimba-Maloko; Lasti Erfinanda; Paul L. Perret; Laura Michalick; Patrick J. Smeele; Endry H. T. Lim; Charissa E. van den Brom; Alexander B. A. Vonk; Toralf Kaiser; Norbert Suttorp; Stefan Hippenstiel; Leif E. Sander; Florian Kurth; Ursula Rauch; Ulf Landmesser; Arash Haghikia; Robert Preissner; Harm J. Bogaard; Martin Witzenrath; Wolfgang M. Kuebler; Robert Szulcek; Szandor Simmons

doi:10.1183/13993003.02009-2022

Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Erik Asmus, Weronika Karle, Markus C. Brack, Corey Wittig, Felix Behrens, Leander Reinshagen, Moritz Pfeiffer, Sabrina Schulz, Bertina Mandzimba-Maloko, Lasti Erfinanda, Paul L. Perret, Laura Michalick, Patrick J. Smeele, Endry H. T. Lim, Charissa E. van den Brom, Alexander B. A. Vonk, Toralf Kaiser, Norbert Suttorp, Stefan Hippenstiel, Leif E. SanderFlorian Kurth, Ursula Rauch, Ulf Landmesser, Arash Haghikia, Robert Preissner, Harm J. Bogaard, Martin Witzenrath, Wolfgang M. Kuebler, Robert Szulcek, Szandor Simmons

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	2202009
Journal	The European respiratory journal
Volume	61
Issue number	3
DOIs	https://doi.org/10.1183/13993003.02009-2022
Publication status	Published - 1 Mar 2023

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10.1183/13993003.02009-2022

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Asmus, E., Karle, W., Brack, M. C., Wittig, C., Behrens, F., Reinshagen, L., Pfeiffer, M., Schulz, S., Mandzimba-Maloko, B., Erfinanda, L., Perret, P. L., Michalick, L., Smeele, P. J., Lim, E. H. T., van den Brom, C. E., Vonk, A. B. A., Kaiser, T., Suttorp, N., Hippenstiel, S., ... Simmons, S. (2023). Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients. The European respiratory journal, 61(3), [2202009]. https://doi.org/10.1183/13993003.02009-2022

@article{35217022343a4bd1bbb32a63d1c6e8c3,

title = "Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients",

author = "Erik Asmus and Weronika Karle and Brack, {Markus C.} and Corey Wittig and Felix Behrens and Leander Reinshagen and Moritz Pfeiffer and Sabrina Schulz and Bertina Mandzimba-Maloko and Lasti Erfinanda and Perret, {Paul L.} and Laura Michalick and Smeele, {Patrick J.} and Lim, {Endry H. T.} and {van den Brom}, {Charissa E.} and Vonk, {Alexander B. A.} and Toralf Kaiser and Norbert Suttorp and Stefan Hippenstiel and Sander, {Leif E.} and Florian Kurth and Ursula Rauch and Ulf Landmesser and Arash Haghikia and Robert Preissner and Bogaard, {Harm J.} and Martin Witzenrath and Kuebler, {Wolfgang M.} and Robert Szulcek and Szandor Simmons",

note = "Funding Information: Support statement: F. Behrens received funding from the Berlin Institute of Health (BIH). L. Michalick reports grants from the BIH and the German Centre for Cardiovascular Research (DZHK). A. Haghikia is participant in the BIH-Charit{\'e} Advanced Clinician Scientist Pilotprogram funded by the Charit{\'e} – Universit{\"a}tsmedizin Berlin and the BIH and reports a research grant within the BIH and MDC Focus Area Translational Vascular Biomedicine. R. Preissner reports partial funding of this work by the German Research Foundation (KFO339, TRR295). M. Witzenrath reports grants from the German Research Foundation (SFB-TR84 C06 and C09, SFB 1449 B02), and from the German Ministry of Education and Research (BMBF) in the framework of CAPSyS (01ZX1604B, 01ZX1304B), SYMPATH (01ZX1906A), PROVID (01KI20160A), Phage4Cure (16GW0141), MAPVAP (16GW0247) and NUM-NAPKON. W.M. Kuebler reports grants from the German Research Foundation (SFB-TR84 A2 and C9, SFB 1449 B1, SFB 1470 A4, KU1218/9-1, KU1218/11-1, and KU1218/12-1), the BMBF in the framework of SYMPATH (01ZX1906A) and PROVID (01KI20160A), and the DZHK. S. Simmons reports grants from the DZHK and the German Foundation for Heart Research (F-09-19). Funding information for this article has been deposited with the Crossref Funder Registry. Funding Information: We would like to thank all medical, paramedical, laboratory and nursing staff involved in the care of the COVD-19 patients and for realising the patient recruitment at Charit{\'e} – Universit{\"a}tmedizin Berlin, Germany, and Amsterdam UMC, The Netherlands. F. Behrens received funding from the Berlin Institute of Health (BIH). L. Michalick reports grants from the BIH and the German Centre for Cardiovascular Research (DZHK). A. Haghikia is participant in the BIH-Charit{\'e} Advanced Clinician Scientist Pilotprogram funded by the Charit{\'e} – Universit{\"a}tsmedizin Berlin and the BIH and reports a research grant within the BIH and MDC Focus Area Translational Vascular Biomedicine. R. Preissner reports partial funding of this work by the German Research Foundation (KFO339, TRR295). M. Witzenrath reports grants from the German Research Foundation (SFB-TR84 C06 and C09, SFB 1449 B02), and from the German Ministry of Education and Research (BMBF) in the framework of CAPSyS (01ZX1604B, 01ZX1304B), SYMPATH (01ZX1906A), PROVID (01KI20160A), Phage4Cure (16GW0141), MAPVAP (16GW0247) and NUM-NAPKON. W.M. Kuebler reports grants from the German Research Foundation (SFB-TR84 A2 and C9, SFB 1449 B1, SFB 1470 A4, KU1218/9-1, KU1218/11-1, and KU1218/12-1), the BMBF in the framework of SYMPATH (01ZX1906A) and PROVID (01KI20160A), and the DZHK. S. Simmons reports grants from the DZHK and the German Foundation for Heart Research (F-09-19). Funding information for this article has been deposited with the Crossref Funder Registry.",

year = "2023",

month = mar,

day = "1",

doi = "10.1183/13993003.02009-2022",

language = "English",

volume = "61",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "3",

}

Asmus, E, Karle, W, Brack, MC, Wittig, C, Behrens, F, Reinshagen, L, Pfeiffer, M, Schulz, S, Mandzimba-Maloko, B, Erfinanda, L, Perret, PL, Michalick, L, Smeele, PJ, Lim, EHT, van den Brom, CE , Vonk, ABA, Kaiser, T, Suttorp, N, Hippenstiel, S, Sander, LE, Kurth, F, Rauch, U, Landmesser, U, Haghikia, A, Preissner, R, Bogaard, HJ, Witzenrath, M, Kuebler, WM, Szulcek, R & Simmons, S 2023, 'Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients', The European respiratory journal, vol. 61, no. 3, 2202009. https://doi.org/10.1183/13993003.02009-2022

Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients. / Asmus, Erik; Karle, Weronika; Brack, Markus C. et al.
In: The European respiratory journal, Vol. 61, No. 3, 2202009, 01.03.2023.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

AU - Asmus, Erik

AU - Karle, Weronika

AU - Brack, Markus C.

AU - Wittig, Corey

AU - Behrens, Felix

AU - Reinshagen, Leander

AU - Pfeiffer, Moritz

AU - Schulz, Sabrina

AU - Mandzimba-Maloko, Bertina

AU - Erfinanda, Lasti

AU - Perret, Paul L.

AU - Michalick, Laura

AU - Smeele, Patrick J.

AU - Lim, Endry H. T.

AU - van den Brom, Charissa E.

AU - Vonk, Alexander B. A.

AU - Kaiser, Toralf

AU - Suttorp, Norbert

AU - Hippenstiel, Stefan

AU - Sander, Leif E.

AU - Kurth, Florian

AU - Rauch, Ursula

AU - Landmesser, Ulf

AU - Haghikia, Arash

AU - Preissner, Robert

AU - Bogaard, Harm J.

AU - Witzenrath, Martin

AU - Kuebler, Wolfgang M.

AU - Szulcek, Robert

AU - Simmons, Szandor

N1 - Funding Information: Support statement: F. Behrens received funding from the Berlin Institute of Health (BIH). L. Michalick reports grants from the BIH and the German Centre for Cardiovascular Research (DZHK). A. Haghikia is participant in the BIH-Charité Advanced Clinician Scientist Pilotprogram funded by the Charité – Universitätsmedizin Berlin and the BIH and reports a research grant within the BIH and MDC Focus Area Translational Vascular Biomedicine. R. Preissner reports partial funding of this work by the German Research Foundation (KFO339, TRR295). M. Witzenrath reports grants from the German Research Foundation (SFB-TR84 C06 and C09, SFB 1449 B02), and from the German Ministry of Education and Research (BMBF) in the framework of CAPSyS (01ZX1604B, 01ZX1304B), SYMPATH (01ZX1906A), PROVID (01KI20160A), Phage4Cure (16GW0141), MAPVAP (16GW0247) and NUM-NAPKON. W.M. Kuebler reports grants from the German Research Foundation (SFB-TR84 A2 and C9, SFB 1449 B1, SFB 1470 A4, KU1218/9-1, KU1218/11-1, and KU1218/12-1), the BMBF in the framework of SYMPATH (01ZX1906A) and PROVID (01KI20160A), and the DZHK. S. Simmons reports grants from the DZHK and the German Foundation for Heart Research (F-09-19). Funding information for this article has been deposited with the Crossref Funder Registry. Funding Information: We would like to thank all medical, paramedical, laboratory and nursing staff involved in the care of the COVD-19 patients and for realising the patient recruitment at Charité – Universitätmedizin Berlin, Germany, and Amsterdam UMC, The Netherlands. F. Behrens received funding from the Berlin Institute of Health (BIH). L. Michalick reports grants from the BIH and the German Centre for Cardiovascular Research (DZHK). A. Haghikia is participant in the BIH-Charité Advanced Clinician Scientist Pilotprogram funded by the Charité – Universitätsmedizin Berlin and the BIH and reports a research grant within the BIH and MDC Focus Area Translational Vascular Biomedicine. R. Preissner reports partial funding of this work by the German Research Foundation (KFO339, TRR295). M. Witzenrath reports grants from the German Research Foundation (SFB-TR84 C06 and C09, SFB 1449 B02), and from the German Ministry of Education and Research (BMBF) in the framework of CAPSyS (01ZX1604B, 01ZX1304B), SYMPATH (01ZX1906A), PROVID (01KI20160A), Phage4Cure (16GW0141), MAPVAP (16GW0247) and NUM-NAPKON. W.M. Kuebler reports grants from the German Research Foundation (SFB-TR84 A2 and C9, SFB 1449 B1, SFB 1470 A4, KU1218/9-1, KU1218/11-1, and KU1218/12-1), the BMBF in the framework of SYMPATH (01ZX1906A) and PROVID (01KI20160A), and the DZHK. S. Simmons reports grants from the DZHK and the German Foundation for Heart Research (F-09-19). Funding information for this article has been deposited with the Crossref Funder Registry.

PY - 2023/3/1

Y1 - 2023/3/1

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150912834&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/36958745

U2 - 10.1183/13993003.02009-2022

DO - 10.1183/13993003.02009-2022

M3 - Article

C2 - 36958745

SN - 0903-1936

VL - 61

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 3

M1 - 2202009

ER -

Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

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