Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia

Ming Y. Tjiong, Nine Van Der Vange, Jan S. Ter Schegget, Matthé P.M. Burger, Fiebo W.J. Ten Kate, Theo A. Out*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Human papillomavirus (HPV) infections play an important role in the development of cervical neoplasia. To get to a better understanding of the role of cytokines in the development of these neoplasias, we analysed the presence of various cytokines in cervicovaginal washings of healthy volunteers (n = 22), cervical intraepithelial neoplasia (CIN) patients (n = 63) and cervical cancer patients (n = 33). IL-12p40, IL-10, TGF-β1, TNF-α and IL-1β levels were significantly higher in patients with cervical cancer than in controls and CIN patients. The levels of IFN-γ were not different. Our data demonstrate alterations in the local cervical immune environment in cervical cancer patients. This could have important consequences for the further development of immune modulating therapies and vaccination strategies.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalCytokine
Volume14
Issue number6
DOIs
Publication statusPublished - 21 Jun 2001

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