Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

A. E. Williams; A. M. van Dam; W. K.H. Man-A-Hing; F. Berkenbosch; P. Eikelenboom; H. Fraser

doi:10.1016/0006-8993(94)90480-4

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

A. E. Williams^*, A. M. van Dam, W. K.H. Man-A-Hing, F. Berkenbosch, P. Eikelenboom, H. Fraser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1β, tumour necrosis factor α, prostaglandin E₂, prostaglandin F_2α and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

Original language	English
Pages (from-to)	200-206
Number of pages	7
Journal	Brain Research
Volume	654
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)90480-4
Publication status	Published - 22 Aug 1994

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title = "Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice",

abstract = "The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1β, tumour necrosis factor α, prostaglandin E2, prostaglandin F2α and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.",

keywords = "Astrocyte, Cytokine, Lipocortin, Mouse, Neurodegeneration, Prostaglandin, Scrapie",

author = "Williams, {A. E.} and {van Dam}, {A. M.} and Man-A-Hing, {W. K.H.} and F. Berkenbosch and P. Eikelenboom and H. Fraser",

year = "1994",

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T1 - Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

AU - Williams, A. E.

AU - van Dam, A. M.

AU - Man-A-Hing, W. K.H.

AU - Berkenbosch, F.

AU - Eikelenboom, P.

AU - Fraser, H.

PY - 1994/8/22

Y1 - 1994/8/22

N2 - The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1β, tumour necrosis factor α, prostaglandin E2, prostaglandin F2α and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

AB - The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1β, tumour necrosis factor α, prostaglandin E2, prostaglandin F2α and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

KW - Astrocyte

KW - Cytokine

KW - Lipocortin

KW - Mouse

KW - Neurodegeneration

KW - Prostaglandin

KW - Scrapie

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DO - 10.1016/0006-8993(94)90480-4

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C2 - 7987669

AN - SCOPUS:0027936612

VL - 654

SP - 200

EP - 206

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

Abstract

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