Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

A. E. Williams*, A. M. van Dam, W. K.H. Man-A-Hing, F. Berkenbosch, P. Eikelenboom, H. Fraser

*Corresponding author for this work

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The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1β, tumour necrosis factor α, prostaglandin E2, prostaglandin F and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalBrain Research
Issue number2
Publication statusPublished - 22 Aug 1994

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