@article{e0c81d0409864c0f821f1c71625ac6c8,
title = "DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells",
abstract = "Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.",
keywords = "CD4 Antigens/physiology, CD4-Positive T-Lymphocytes/cytology, Cell Adhesion Molecules/physiology, Cell Movement, Cells, Cultured, Cervix Uteri/cytology, Coculture Techniques, Dendritic Cells/immunology, Female, HIV Envelope Protein gp120/metabolism, HIV Infections/transmission, HIV-1/physiology, Humans, Lectins/physiology, Lymph Nodes/cytology, Lymphoid Tissue/cytology, Macromolecular Substances, Male, Mucous Membrane/cytology, Receptors, CCR5/physiology, Receptors, HIV/physiology, Rectum/cytology, Transfection, Uterus/cytology",
author = "Geijtenbeek, {T B} and Kwon, {D S} and R Torensma and {van Vliet}, {S J} and {van Duijnhoven}, {G C} and J Middel and Cornelissen, {I L} and Nottet, {H S} and KewalRamani, {V N} and Littman, {D R} and Figdor, {C G} and {van Kooyk}, Y",
year = "2000",
month = mar,
day = "3",
language = "English",
volume = "100",
pages = "587--97",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}