DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review

T B Geijtenbeek; S J van Vliet; G C van Duijnhoven; C G Figdor; Y van Kooyk

doi:10.1053/plac.2001.0674

DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review

T B Geijtenbeek, S J van Vliet, G C van Duijnhoven, C G Figdor, Y van Kooyk

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.

Original language	English
Pages (from-to)	S19-23
Journal	Placenta
Volume	22 Suppl A
DOIs	https://doi.org/10.1053/plac.2001.0674
Publication status	Published - Apr 2001

Access to Document

10.1053/plac.2001.0674

Cite this

@article{79a0aa81238341a7af6e5d5fc17323ef,

title = "DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review",

abstract = "Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.",

keywords = "Cell Adhesion Molecules, Female, HIV Envelope Protein gp120/metabolism, HIV-1/metabolism, Humans, Lectins/metabolism, Lectins, C-Type, Lymph Nodes/metabolism, Mucous Membrane/metabolism, Placenta/metabolism, Pregnancy, Pregnancy Complications, Infectious, Receptors, Cell Surface/metabolism, Receptors, HIV/metabolism, T-Lymphocytes/metabolism, Viral Proteins/metabolism",

author = "Geijtenbeek, {T B} and {van Vliet}, {S J} and {van Duijnhoven}, {G C} and Figdor, {C G} and {van Kooyk}, Y",

year = "2001",

month = apr,

doi = "10.1053/plac.2001.0674",

language = "English",

volume = "22 Suppl A",

pages = "S19--23",

journal = "Placenta",

issn = "0143-4004",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review

AU - Geijtenbeek, T B

AU - van Vliet, S J

AU - van Duijnhoven, G C

AU - Figdor, C G

AU - van Kooyk, Y

PY - 2001/4

Y1 - 2001/4

N2 - Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.

AB - Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.

KW - Cell Adhesion Molecules

KW - Female

KW - HIV Envelope Protein gp120/metabolism

KW - HIV-1/metabolism

KW - Humans

KW - Lectins/metabolism

KW - Lectins, C-Type

KW - Lymph Nodes/metabolism

KW - Mucous Membrane/metabolism

KW - Placenta/metabolism

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Receptors, Cell Surface/metabolism

KW - Receptors, HIV/metabolism

KW - T-Lymphocytes/metabolism

KW - Viral Proteins/metabolism

U2 - 10.1053/plac.2001.0674

DO - 10.1053/plac.2001.0674

M3 - Review article

C2 - 11312623

VL - 22 Suppl A

SP - S19-23

JO - Placenta

JF - Placenta

SN - 0143-4004

ER -