DC-SIGN and LFA-1: a battle for ligand

D A Bleijs, T B Geijtenbeek, C G Figdor, Y van Kooyk

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.

Original languageEnglish
Pages (from-to)457-63
Number of pages7
JournalTrends in Immunology
Volume22
Issue number8
Publication statusPublished - Aug 2001

Cite this

Bleijs, D A ; Geijtenbeek, T B ; Figdor, C G ; van Kooyk, Y. / DC-SIGN and LFA-1 : a battle for ligand. In: Trends in Immunology. 2001 ; Vol. 22, No. 8. pp. 457-63.
@article{b5510e992b0d4686b0938c372ccd64cb,
title = "DC-SIGN and LFA-1: a battle for ligand",
abstract = "The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.",
keywords = "Animals, Cell Adhesion Molecules/immunology, Dendritic Cells/immunology, Humans, Lectins/chemistry, Lectins, C-Type, Ligands, Lymphocyte Function-Associated Antigen-1/chemistry, Receptors, Cell Surface/chemistry, T-Lymphocytes/immunology",
author = "Bleijs, {D A} and Geijtenbeek, {T B} and Figdor, {C G} and {van Kooyk}, Y",
year = "2001",
month = "8",
language = "English",
volume = "22",
pages = "457--63",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "8",

}

Bleijs, DA, Geijtenbeek, TB, Figdor, CG & van Kooyk, Y 2001, 'DC-SIGN and LFA-1: a battle for ligand' Trends in Immunology, vol. 22, no. 8, pp. 457-63.

DC-SIGN and LFA-1 : a battle for ligand. / Bleijs, D A; Geijtenbeek, T B; Figdor, C G; van Kooyk, Y.

In: Trends in Immunology, Vol. 22, No. 8, 08.2001, p. 457-63.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - DC-SIGN and LFA-1

T2 - a battle for ligand

AU - Bleijs, D A

AU - Geijtenbeek, T B

AU - Figdor, C G

AU - van Kooyk, Y

PY - 2001/8

Y1 - 2001/8

N2 - The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.

AB - The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.

KW - Animals

KW - Cell Adhesion Molecules/immunology

KW - Dendritic Cells/immunology

KW - Humans

KW - Lectins/chemistry

KW - Lectins, C-Type

KW - Ligands

KW - Lymphocyte Function-Associated Antigen-1/chemistry

KW - Receptors, Cell Surface/chemistry

KW - T-Lymphocytes/immunology

M3 - Review article

VL - 22

SP - 457

EP - 463

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 8

ER -