DC-SIGN and LFA-1: a battle for ligand

D A Bleijs, T B Geijtenbeek, C G Figdor, Y van Kooyk

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The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.

Original languageEnglish
Pages (from-to)457-63
Number of pages7
JournalTrends in Immunology
Issue number8
Publication statusPublished - Aug 2001

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