DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking

T B Geijtenbeek, D J Krooshoop, D A Bleijs, S J van Vliet, G C van Duijnhoven, V Grabovsky, R Alon, C G Figdor, Y van Kooyk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After antigen uptake and processing, DCs migrate to the secondary lymphoid organs to initiate immune responses. We now show that DC-SIGN, a DC-specific C-type lectin, supports tethering and rolling of DC-SIGN-positive cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for emigration from blood. The DC-SIGN-ICAM-2 interaction regulates chemokine-induced transmigration of DCs across both resting and activated endothelium. Thus, DC-SIGN is central to the unusual trafficking capacity of DCs, further supported by the expression of DC-SIGN on precursors in blood and on immature and mature DCs in both peripheral and lymphoid tissues.

Original languageEnglish
Pages (from-to)353-7
Number of pages5
JournalNature Immunology
Volume1
Issue number4
DOIs
Publication statusPublished - Oct 2000

Cite this

Geijtenbeek, T. B., Krooshoop, D. J., Bleijs, D. A., van Vliet, S. J., van Duijnhoven, G. C., Grabovsky, V., ... van Kooyk, Y. (2000). DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nature Immunology, 1(4), 353-7. https://doi.org/10.1038/79815
Geijtenbeek, T B ; Krooshoop, D J ; Bleijs, D A ; van Vliet, S J ; van Duijnhoven, G C ; Grabovsky, V ; Alon, R ; Figdor, C G ; van Kooyk, Y. / DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. In: Nature Immunology. 2000 ; Vol. 1, No. 4. pp. 353-7.
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Geijtenbeek, TB, Krooshoop, DJ, Bleijs, DA, van Vliet, SJ, van Duijnhoven, GC, Grabovsky, V, Alon, R, Figdor, CG & van Kooyk, Y 2000, 'DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking' Nature Immunology, vol. 1, no. 4, pp. 353-7. https://doi.org/10.1038/79815

DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. / Geijtenbeek, T B; Krooshoop, D J; Bleijs, D A; van Vliet, S J; van Duijnhoven, G C; Grabovsky, V; Alon, R; Figdor, C G; van Kooyk, Y.

In: Nature Immunology, Vol. 1, No. 4, 10.2000, p. 353-7.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Geijtenbeek, T B

AU - Krooshoop, D J

AU - Bleijs, D A

AU - van Vliet, S J

AU - van Duijnhoven, G C

AU - Grabovsky, V

AU - Alon, R

AU - Figdor, C G

AU - van Kooyk, Y

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AB - Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After antigen uptake and processing, DCs migrate to the secondary lymphoid organs to initiate immune responses. We now show that DC-SIGN, a DC-specific C-type lectin, supports tethering and rolling of DC-SIGN-positive cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for emigration from blood. The DC-SIGN-ICAM-2 interaction regulates chemokine-induced transmigration of DCs across both resting and activated endothelium. Thus, DC-SIGN is central to the unusual trafficking capacity of DCs, further supported by the expression of DC-SIGN on precursors in blood and on immature and mature DCs in both peripheral and lymphoid tissues.

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KW - Humans

KW - Immunity, Cellular

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Geijtenbeek TB, Krooshoop DJ, Bleijs DA, van Vliet SJ, van Duijnhoven GC, Grabovsky V et al. DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nature Immunology. 2000 Oct;1(4):353-7. https://doi.org/10.1038/79815