DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking

T B Geijtenbeek, D J Krooshoop, D A Bleijs, S J van Vliet, G C van Duijnhoven, V Grabovsky, R Alon, C G Figdor, Y van Kooyk

Research output: Contribution to journalArticleAcademicpeer-review


Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After antigen uptake and processing, DCs migrate to the secondary lymphoid organs to initiate immune responses. We now show that DC-SIGN, a DC-specific C-type lectin, supports tethering and rolling of DC-SIGN-positive cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for emigration from blood. The DC-SIGN-ICAM-2 interaction regulates chemokine-induced transmigration of DCs across both resting and activated endothelium. Thus, DC-SIGN is central to the unusual trafficking capacity of DCs, further supported by the expression of DC-SIGN on precursors in blood and on immature and mature DCs in both peripheral and lymphoid tissues.

Original languageEnglish
Pages (from-to)353-7
Number of pages5
JournalNature Immunology
Issue number4
Publication statusPublished - Oct 2000

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