De invloed van wittestofafwijkingen op ouderdomsdepressies

Translated title of the contribution: The influence of white matter lesions on geriatric depressions

F. B. Van Der Wurff, A. T.F. Beekman, D. J. Veltman, W. J.G. Hoogendijk, Ph Scheltens, H. C. Weinstein

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: White matter lesions are recognisable as hyperintense lesions on Magnetic Resonance Imaging. These white matter lesions occur regularly in depressed elderly, especially in those with a late-onset depression. However, the relevance of white matter lesions for late-life depression remains obscure. They also occur in the non-depressive elderly. AIMS: This review article describes the relevance of white matter lesions of the brain for the aetiology, the symptomatology and the course of depression in the elderly. METHODS: Articles considering the relation between white matter lesions and late-life depressions were selected by means of a search in Medline. RESULTS: White matter lesions can influence the symptoms of late-life depressions. Especially subcortical white matter lesions seriously affect the outcome of late-life depressions. CONCLUSIONS: The presence of white matter lesions has major consequences for the treatment of late-life depressions.

Translated title of the contributionThe influence of white matter lesions on geriatric depressions
Original languageDutch
Pages (from-to)595-604
Number of pages10
JournalTijdschrift voor Psychiatrie
Issue number8
Publication statusPublished - 1 Dec 2000

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