Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine

J. De Gans, J. M.A. Lange, M. M.A. Derix, F. De Wolf, J. K.M. Eeftinck Schattenkerk, S. A. Danner, B. W. Ongerboer De Visser, P. Cload, J. Goudsmit

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Six HIV-antigenaemic patients with AIDS or AIDS-related complex were studied to assess the effect of treatment with low-dose zidovudine (250 mg) in 6-hourly doses on HIV antigen (HIV-Ag) levels in cerebrospinal fluid (CSF). HIV-Ag was detected in CSF of three patients before treatment. These patients became CSF HIV-Ag-negative within 8 weeks of treatment. One initially CSF HIV-Ag-negative patient became strongly CSF HIV-Ag-positive during interruption of zidovudine treatment; CSF HIV-Ag disappeared again after treatment was restarted. None of our patients showed a significant neurological improvement during the study. These results show that low-dose zidovudine can suppress viral expression in CSF. Whether suppression of viral replication can prevent future HIV-related neurological disease remaines to be investigated.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalAIDS
Volume2
Issue number1
DOIs
Publication statusPublished - 1988

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