Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept: results from the 2-year ACTION study

Rieke Alten, Hubert Nüßlein, Mauro Galeazzi, Hanns-Martin Lorenz, Michael T Nurmohamed, William G Bensen, Gerd R Burmester, Hans-Hartmut Peter, Karel Pavelka, Mélanie Chartier, Coralie Poncet, Christiane Rauch, Yedid Elbez, Manuela Le Bars

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

INTRODUCTION: Prolonged glucocorticoid use may increase the risk of adverse safety outcomes, including cardiovascular events. The European League Against Rheumatism and the Canadian Rheumatology Association advise tapering glucocorticoid dose as rapidly as clinically feasible. There is a paucity of published data on RA that adequately describe concomitant treatment patterns.

METHODS: ACTION (AbataCepT In rOutiNe clinical practice) is a non-interventional cohort study of patients from Europe and Canada that investigated the long-term retention of intravenous abatacept in clinical practice. We assessed concomitant glucocorticoids in patients with established RA who had participated in ACTION and received ≥1 biological agent prior to abatacept initiation.

RESULTS: The analysis included 1009 patients. Glucocorticoids were prescribed at abatacept initiation in 734 (72.7%) patients at a median 7.5 mg/day dose (n=692). Of the patients who remained on abatacept at 24 months, 40.7% were able to decrease their dose of glucocorticoids, including 26.9% who decreased their dose from >5 mg/day to ≤5 mg/day.

CONCLUSION: Reduction and/or cessation of glucocorticoid therapy is possible with intravenous abatacept in clinical practice.

Original languageEnglish
Article numbere000228
JournalRMD Open
Volume2
Issue number1
DOIs
Publication statusPublished - 2016

Cite this

Alten, Rieke ; Nüßlein, Hubert ; Galeazzi, Mauro ; Lorenz, Hanns-Martin ; Nurmohamed, Michael T ; Bensen, William G ; Burmester, Gerd R ; Peter, Hans-Hartmut ; Pavelka, Karel ; Chartier, Mélanie ; Poncet, Coralie ; Rauch, Christiane ; Elbez, Yedid ; Le Bars, Manuela. / Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept : results from the 2-year ACTION study. In: RMD Open. 2016 ; Vol. 2, No. 1.
@article{95e352da1b8a4285a45df6acf5e633f8,
title = "Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept: results from the 2-year ACTION study",
abstract = "INTRODUCTION: Prolonged glucocorticoid use may increase the risk of adverse safety outcomes, including cardiovascular events. The European League Against Rheumatism and the Canadian Rheumatology Association advise tapering glucocorticoid dose as rapidly as clinically feasible. There is a paucity of published data on RA that adequately describe concomitant treatment patterns.METHODS: ACTION (AbataCepT In rOutiNe clinical practice) is a non-interventional cohort study of patients from Europe and Canada that investigated the long-term retention of intravenous abatacept in clinical practice. We assessed concomitant glucocorticoids in patients with established RA who had participated in ACTION and received ≥1 biological agent prior to abatacept initiation.RESULTS: The analysis included 1009 patients. Glucocorticoids were prescribed at abatacept initiation in 734 (72.7{\%}) patients at a median 7.5 mg/day dose (n=692). Of the patients who remained on abatacept at 24 months, 40.7{\%} were able to decrease their dose of glucocorticoids, including 26.9{\%} who decreased their dose from >5 mg/day to ≤5 mg/day.CONCLUSION: Reduction and/or cessation of glucocorticoid therapy is possible with intravenous abatacept in clinical practice.",
keywords = "Journal Article",
author = "Rieke Alten and Hubert N{\"u}{\ss}lein and Mauro Galeazzi and Hanns-Martin Lorenz and Nurmohamed, {Michael T} and Bensen, {William G} and Burmester, {Gerd R} and Hans-Hartmut Peter and Karel Pavelka and M{\'e}lanie Chartier and Coralie Poncet and Christiane Rauch and Yedid Elbez and {Le Bars}, Manuela",
year = "2016",
doi = "10.1136/rmdopen-2015-000228",
language = "English",
volume = "2",
journal = "RMD Open",
issn = "2056-5933",
publisher = "BMJ Publishing Group",
number = "1",

}

Alten, R, Nüßlein, H, Galeazzi, M, Lorenz, H-M, Nurmohamed, MT, Bensen, WG, Burmester, GR, Peter, H-H, Pavelka, K, Chartier, M, Poncet, C, Rauch, C, Elbez, Y & Le Bars, M 2016, 'Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept: results from the 2-year ACTION study' RMD Open, vol. 2, no. 1, e000228. https://doi.org/10.1136/rmdopen-2015-000228

Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept : results from the 2-year ACTION study. / Alten, Rieke; Nüßlein, Hubert; Galeazzi, Mauro; Lorenz, Hanns-Martin; Nurmohamed, Michael T; Bensen, William G; Burmester, Gerd R; Peter, Hans-Hartmut; Pavelka, Karel; Chartier, Mélanie; Poncet, Coralie; Rauch, Christiane; Elbez, Yedid; Le Bars, Manuela.

In: RMD Open, Vol. 2, No. 1, e000228, 2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Decreased use of glucocorticoids in biological-experienced patients with rheumatoid arthritis who initiated intravenous abatacept

T2 - results from the 2-year ACTION study

AU - Alten, Rieke

AU - Nüßlein, Hubert

AU - Galeazzi, Mauro

AU - Lorenz, Hanns-Martin

AU - Nurmohamed, Michael T

AU - Bensen, William G

AU - Burmester, Gerd R

AU - Peter, Hans-Hartmut

AU - Pavelka, Karel

AU - Chartier, Mélanie

AU - Poncet, Coralie

AU - Rauch, Christiane

AU - Elbez, Yedid

AU - Le Bars, Manuela

PY - 2016

Y1 - 2016

N2 - INTRODUCTION: Prolonged glucocorticoid use may increase the risk of adverse safety outcomes, including cardiovascular events. The European League Against Rheumatism and the Canadian Rheumatology Association advise tapering glucocorticoid dose as rapidly as clinically feasible. There is a paucity of published data on RA that adequately describe concomitant treatment patterns.METHODS: ACTION (AbataCepT In rOutiNe clinical practice) is a non-interventional cohort study of patients from Europe and Canada that investigated the long-term retention of intravenous abatacept in clinical practice. We assessed concomitant glucocorticoids in patients with established RA who had participated in ACTION and received ≥1 biological agent prior to abatacept initiation.RESULTS: The analysis included 1009 patients. Glucocorticoids were prescribed at abatacept initiation in 734 (72.7%) patients at a median 7.5 mg/day dose (n=692). Of the patients who remained on abatacept at 24 months, 40.7% were able to decrease their dose of glucocorticoids, including 26.9% who decreased their dose from >5 mg/day to ≤5 mg/day.CONCLUSION: Reduction and/or cessation of glucocorticoid therapy is possible with intravenous abatacept in clinical practice.

AB - INTRODUCTION: Prolonged glucocorticoid use may increase the risk of adverse safety outcomes, including cardiovascular events. The European League Against Rheumatism and the Canadian Rheumatology Association advise tapering glucocorticoid dose as rapidly as clinically feasible. There is a paucity of published data on RA that adequately describe concomitant treatment patterns.METHODS: ACTION (AbataCepT In rOutiNe clinical practice) is a non-interventional cohort study of patients from Europe and Canada that investigated the long-term retention of intravenous abatacept in clinical practice. We assessed concomitant glucocorticoids in patients with established RA who had participated in ACTION and received ≥1 biological agent prior to abatacept initiation.RESULTS: The analysis included 1009 patients. Glucocorticoids were prescribed at abatacept initiation in 734 (72.7%) patients at a median 7.5 mg/day dose (n=692). Of the patients who remained on abatacept at 24 months, 40.7% were able to decrease their dose of glucocorticoids, including 26.9% who decreased their dose from >5 mg/day to ≤5 mg/day.CONCLUSION: Reduction and/or cessation of glucocorticoid therapy is possible with intravenous abatacept in clinical practice.

KW - Journal Article

U2 - 10.1136/rmdopen-2015-000228

DO - 10.1136/rmdopen-2015-000228

M3 - Article

VL - 2

JO - RMD Open

JF - RMD Open

SN - 2056-5933

IS - 1

M1 - e000228

ER -