Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice

Sjef Copray, Britta Küst, Bart Emmer, May Young Lin, Robert Liem, Sandra Amor, Helga de Vries, Sarah Floris, Erik Boddeke

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We have investigated the role of p75NTR in inflammation in experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS). Induction of EAE in C57/BL6 wild-type mice resulted in expression of p75NTR in endothelial cells in the CNS. In contrast to the clinical manifestation of EAE observed in wild-type C57/BL6 mice, mice deficient for p75NTR (p75NTR knockout mice) developed severe or lethal disease and concomitant increased levels of inflammation in the CNS. Our findings suggest a physiological significant role for p75NTR in CNS endothelial cells during inflammation and involvement in preservation of blood-brain barrier integrity during a severe infiltrative attack.

Original languageEnglish
Pages (from-to)41-53
Number of pages13
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Mar 2004

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