Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram

Hielke-Martijn de Vries, Sarah R. Ottenhof, Simon Horenblas, Michiel S. van der Heijden, Ekaterina S. Jordanova

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Current chemotherapeutic treatment for advanced penile squamous cell carcinoma has substantial side effects and no randomized data to support an overall survival benefit. Immunotherapy with checkpoint blockade is currently being tested in penile cancer patients in clinical trials. The high PD-L1 expression and CD8 + T-cell infiltration in penile cancer represent a promising prospect for immunotherapy response in the treatment of locally advanced disease. For efficacious immunotherapy treatment, a better understanding of the tumor microenvironment (TME) is critical. Here we use the structure revealed by cancer immunograms to define current knowledge of the penile cancer TME as a backbone for future research. Patient summary: Advanced penile cancer has a poor prognosis with a need for more effective therapy. In this manuscript we describe the potential of immunotherapy as a new treatment modality in penile cancer.
Original languageEnglish
JournalEuropean Urology Focus
DOIs
Publication statusPublished - 2019

Cite this

de Vries, Hielke-Martijn ; Ottenhof, Sarah R. ; Horenblas, Simon ; van der Heijden, Michiel S. ; Jordanova, Ekaterina S. / Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram. In: European Urology Focus. 2019.
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abstract = "Current chemotherapeutic treatment for advanced penile squamous cell carcinoma has substantial side effects and no randomized data to support an overall survival benefit. Immunotherapy with checkpoint blockade is currently being tested in penile cancer patients in clinical trials. The high PD-L1 expression and CD8 + T-cell infiltration in penile cancer represent a promising prospect for immunotherapy response in the treatment of locally advanced disease. For efficacious immunotherapy treatment, a better understanding of the tumor microenvironment (TME) is critical. Here we use the structure revealed by cancer immunograms to define current knowledge of the penile cancer TME as a backbone for future research. Patient summary: Advanced penile cancer has a poor prognosis with a need for more effective therapy. In this manuscript we describe the potential of immunotherapy as a new treatment modality in penile cancer.",
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Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram. / de Vries, Hielke-Martijn; Ottenhof, Sarah R.; Horenblas, Simon; van der Heijden, Michiel S.; Jordanova, Ekaterina S.

In: European Urology Focus, 2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram

AU - de Vries, Hielke-Martijn

AU - Ottenhof, Sarah R.

AU - Horenblas, Simon

AU - van der Heijden, Michiel S.

AU - Jordanova, Ekaterina S.

PY - 2019

Y1 - 2019

N2 - Current chemotherapeutic treatment for advanced penile squamous cell carcinoma has substantial side effects and no randomized data to support an overall survival benefit. Immunotherapy with checkpoint blockade is currently being tested in penile cancer patients in clinical trials. The high PD-L1 expression and CD8 + T-cell infiltration in penile cancer represent a promising prospect for immunotherapy response in the treatment of locally advanced disease. For efficacious immunotherapy treatment, a better understanding of the tumor microenvironment (TME) is critical. Here we use the structure revealed by cancer immunograms to define current knowledge of the penile cancer TME as a backbone for future research. Patient summary: Advanced penile cancer has a poor prognosis with a need for more effective therapy. In this manuscript we describe the potential of immunotherapy as a new treatment modality in penile cancer.

AB - Current chemotherapeutic treatment for advanced penile squamous cell carcinoma has substantial side effects and no randomized data to support an overall survival benefit. Immunotherapy with checkpoint blockade is currently being tested in penile cancer patients in clinical trials. The high PD-L1 expression and CD8 + T-cell infiltration in penile cancer represent a promising prospect for immunotherapy response in the treatment of locally advanced disease. For efficacious immunotherapy treatment, a better understanding of the tumor microenvironment (TME) is critical. Here we use the structure revealed by cancer immunograms to define current knowledge of the penile cancer TME as a backbone for future research. Patient summary: Advanced penile cancer has a poor prognosis with a need for more effective therapy. In this manuscript we describe the potential of immunotherapy as a new treatment modality in penile cancer.

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